DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and Mtm1

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_038967748.1	Gene:	Mtm1 / 288762	RGDID:	1304582	Length:	603	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	206/560 - (36%)
Similarity:	320/560 - (57%)	Gaps:	56/560 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 PTVGTLYLT--ATHLIFVEPDSNKETWILHMH---VASIEKLPLSTTGSP----LLIRCKTFLSV 150
            |..|.||:|  ..:|..:|.|...   ||.:.   ::.|||:...|:...    |.|.||...::
  Rat    58 PVKGRLYITNYRLYLRSLETDLAP---ILDVPLGVISRIEKMGGVTSRGENSYGLDITCKDLRNL 119

  Fly   151 TFVIPKDSEC-HDVYTSLLKLFQPVSIN-KLYCFNYQPNKDDFPKNAGWDYFKLEAEFKHMLVPN 213
            .|.:.::... .|::..|.:...|::.| .|:.|   .|::.| |..||..:....|::...:|:
  Rat   120 RFALKQEGHSRRDIFDVLTRHAFPLAYNLPLFAF---VNEEKF-KVDGWAIYNPVEEYRRQGLPD 180

  Fly   214 EAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLH-NNKASICRCSQP 277
            ..|.:..:|::||||||||..:.||..|:...|...:.|||:.|:|||:::| .|:|:|.|||||
  Rat   181 RHWRISFVNQRYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENRAAIMRCSQP 245

  Fly   278 LSGFSA-RCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYENIKFHFLG 341
            |.|... |..:||:.|:.||:||..|..:.:.|.||.:||:||:|.|.|||.|..|.:.:..||.
  Rat   246 LVGVGGKRSRDDERYLDIIRETNKQTSKLTIYDARPGVNAVANKATGGGYEGEDAYPHAELSFLD 310

  Fly   342 IENIHVQRASLQKVLEA----CEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDKGV-S 401
            |.||||.|.||::|.:.    .|:     :.::::|||:.||:||:.:|..:..:|:.|..|: |
  Rat   311 IHNIHVMRESLRRVRDIVYPHVEE-----AHWLSSLESTHWLEHIKLLLTGAIRVADKVASGLSS 370

  Fly   402 VVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGH---IQTDAREV 463
            |:||||||||||||:.:||.|||:.:||:|:||:.|::|:|::||||||.|.||   ...|| :.
  Rat   371 VLVHCSDGWDRTAQLTTLAMLMLDGFYRSIEGFEILVQKEWISFGHKFSSRIGHGDKNHADA-DR 434

  Fly   464 SPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLW 528
            ||||.||:||.||:..|...||||||.||:.:.||::||:||||:.|||..|...:|||||.|:|
  Rat   435 SPIFLQFIDCVWQMTKQFPTAFEFNECFLVAILDHLYSCRFGTFLLNCEAARERQRLAERTVSVW 499

  Fly   529 GYMANHLNEYINPLYKPNVDEAIKANLAPQCIKFWRGMYSRFESGIHPREPLGDVLLDSKEHCNS 593
            ..:.::.:|:.||.|....:..|....:.:.::.|...|.|:...|..::|            :.
  Rat   500 SLINSNKDEFTNPFYARESNRVIYPVTSVRHLELWVNYYIRWNPRIRQQQP------------HP 552

  Fly   594 LEDHVQHLTKRIASFKNYISK-------SAKKLQDATSAP 626
            :|   |...:.:|...:||.|       :..||.|:::.|
  Rat   553 ME---QRYNELLALRDDYIKKLEELQLATPTKLTDSSTPP 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	21/87 (24%)
		Myotub-related	179..514	CDD:284109	155/344 (45%)
		FYVE_MTMR_unchar	693..753	CDD:277277
Mtm1	XP_038967748.1	PH-like	44..143	CDD:418428	21/87 (24%)
Mtm1	XP_038967748.1	Myotub-related	162..489	CDD:399535	151/332 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349482
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850