DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and Mtmr12

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_766546.1	Gene:	Mtmr12 / 268783	MGIID:	2443034	Length:	747	Species:	Mus musculus

Alignment Length:	711	Identity:	174/711 - (24%)
Similarity:	280/711 - (39%)	Gaps:	165/711 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PVPPFVS---EKVVSWIEEEFNEAPVFYN---GNSVLKKVENV-RMIDRYNTKNPTVGTLYLTAT 105
            |.|.|||   .:.:...|:|..|..|..:   |..:|.:...| :.:...:.:....|.|..|..
Mouse    16 PKPSFVSYVRPEEIHTDEKEVTEKEVTLHLLPGEQLLCEASTVLKYVQEDSCQRGVYGRLVCTDF 80

  Fly   106 HLIFV-EPDS-----------NKETWILHMHVASIEKL-------------PLSTTGSPLLIRCK 145
            .:.|: :.||           ||...:..:.:..::::             .|......|:|.||
Mouse    81 KISFLGDEDSALDNGGEAQFKNKIIGVNDVPLHCVDQIYGVFDEKKKPLFGQLKKYPEKLVIHCK 145

  Fly   146 TFLSVTFVI--PKDSECHDVYTSLLKLFQ-PVSINKLYCFNYQPNKD-------------DFPKN 194
            ....:.|.:  .|:.|...:.:.::...| |..:.:|:.|:|.....             |.||:
Mouse   146 DLRVLHFCLRYTKEEEVKRIVSGIIHHTQSPKLLKRLFLFSYAAAVHGTATDSRNCTVMFDTPKD 210

  Fly   195 AGWDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLP 259
            ..|:..:.:...|:..|        |:||.|.:.|..|....||   |.|......||:..| :|
Mouse   211 WCWELERTKGSVKYRTV--------SVNEGYRVSDRLPAYFVVP---TPLPEDDVRRFQGHG-IP 263

  Fly   260 VLTYLHNNKASICRCSQPLSGFSARCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGK 324
            :..:..:|.:::.:.|         .|..||...|::...|..|.:|....||.
Mouse   264 IWCWSCHNGSALLKMS---------ALPKEQDDGALQVQKSFLDGIYKTIHRPP----------- 308

  Fly   325 GYENEAFYENIKFHFLGIENIHVQRASLQKVLEA-CEQKS-----------PTMSAFINALESSG 377
                   ||.:|     .|::.....|||::..| |:.|.           .|...:.:.||||.
Mouse   309 -------YEMVK-----TEDLSSNFLSLQEIQSAYCKFKQLFLIDNSSEFWDTDIKWFSLLESSS 361

  Fly   378 WLKHIRSILDTSSFIANAVD-KGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKD 441
            ||..||..|..:..|...:: :.|:|::...:..|....:.||.|:|::.:.||..|||:||:|:
Mouse   362 WLDIIRRCLKKAIEITECLEAQNVNVLLLEENASDLCCLLSSLVQVMMDAHCRTRTGFQSLIQKE 426

  Fly   442 WLAFGHKFSERCGHIQTDAREVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGT 506
            |:..||.|.:||.|:....:|..|||..||||.|||:.|...||||.|.:|.:|.|.::...|.|
Mouse   427 WVMGGHSFLDRCNHLHQSDKEEVPIFLLFLDCVWQLVHQYPPAFEFTETYLTVLSDSLYIPIFST 491

  Fly   507 FVGNC--EKD----RLDLKLAERTFSL-----WGYMANHLNEYI--NPLY--KPNVDEAIKANLA 556
            |..|.  :||    |.:|....:..:|     |........:.:  ||||  ||.:|
Mouse   492 FFFNSPHQKDTNMGRENLDAQSKPLTLLTVWDWSVQFEPKAQTLLRNPLYVEKPKLD-------- 548

  Fly   557 PQCIKFWRGMY--SRFESGIHPREPLGDVLLDSKEHCNS--LEDHVQHLTKRIASFKNYISKSAK 617
                   ||..  |||:   |.|: |...|..||.....  ..:...||      .||.:.|...
Mouse   549 -------RGQQKGSRFK---HQRQ-LSLPLTQSKSSPKRGFFREETDHL------IKNLLGKRIS 596

  Fly   618 KLQDATSAPGKVNKELSSNEINDNKYN-YDKKLSELSAADDDHPLKASNMSFASLSLSAEQ 677
            ||         :|   ||:::.|:... ||   |..|...|.|.|...::....:.:.|::
Mouse   597 KL---------IN---SSDDLQDSSREFYD---SWHSKPTDYHGLLLPHIEGPEIKVWAQR 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	19/123 (15%)
		Myotub-related	179..514	CDD:284109	101/362 (28%)
		FYVE_MTMR_unchar	693..753	CDD:277277
Mtmr12	NP_766546.1	PH-like	26..204	CDD:302622	28/177 (16%)
		PTPc	210..496	CDD:304379	94/329 (29%)
		Interaction with MTM1. /evidence=ECO:0000250	449..558		40/123 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..575		12/45 (27%)
		3-PAP	561..685	CDD:289355	24/104 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740