Protein Alignment CG3530 and mtm-6

DIOPT Version :9

• Sequence 1: NP_726322.1
• Gene: CG3530 / 37707
• FlyBaseID: FBgn0028497
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_871680.1
• Gene: mtm-6 / 176757
• WormBaseID: WBGene00003478
• Length: 782
• Species: Caenorhabditis elegans
• Alignment Length: 681
• Identity: 291/681 - (42%)
• Similarity: 422/681 - (61%)
• Gaps: 62/681 - (9%)

  Fly    81 VENVRMIDRYNTKNPTVGTLYLTATHLIFVEPDSNKETWILHMHVASIEKLPLSTTGSPLLIRCK 145
            |:.|.::||...:...|||:::|.||:||...:.:||.|:....::|:||..|:..|..|:||||
 Worm   117 VDKVCLVDRLGCQENLVGTVHVTTTHIIFRAENGSKELWLATGLISSVEKGTLTAAGCMLVIRCK 181

  Fly   146 TFLSVTFVIPKDSECHDVYTSLLKLFQPVSIN--KLYCF-NYQPNKDDFPKNAGWDYFKLEAEFK 207
            .|..:|.:|.:|..|.|:|.:|.:..:|||:|  :|..| |.:|.:|    ..||......:|..
 Worm   182 HFQVITLLISRDKSCQDLYETLQRAAKPVSVNVTELLAFENREPVED----VRGWRRLDWNSEMT 242

  Fly   208 HMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLTYLH-NNKASI 271
            ...:....||..::||.|.:|||||.:::.|..|:|.:|:.|.:|||:||||||||.| ..:|::
 Worm   243 RQGITKSQWTESNINEGYTICDTYPNKLWFPTAASTSVLLGSCKFRSRGRLPVLTYFHQQTEAAL 307

  Fly   272 CRCSQPLSGFSARCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYENIK 336
            |||:|||:||||||:|||:::|.:.|.|:|:|.:::||||||:|||.|:..|||:|:|..|.|::
 Worm   308 CRCAQPLTGFSARCVEDEKLMELVGKANTNSDNLFLVDTRPRVNAMVNKVQGKGFEDERNYSNMR 372

  Fly   337 FHFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDKGVS 401
            |||..||||||.|||..::|:|. .|...::.:...||:||||||:||:::.|.|:|.::.:|.|
 Worm   373 FHFFDIENIHVMRASQARLLDAV-TKCRDVTEYWKTLEASGWLKHVRSVVECSLFLAESISRGTS 436

  Fly   402 VVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHI----QTDARE 462
            .|||||||||||:||.:|.||:|:||||||.|||.|||||||.|||||.:||||:    ....:|
 Worm   437 CVVHCSDGWDRTSQVVALCQLLLDPYYRTIHGFQVLIEKDWLGFGHKFDDRCGHVGALNDEAGKE 501

  Fly   463 VSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSL 527
            |||||||:|||.||:|.|:..||:||||:|:.:|:||:|||||||:|||:|||.||.|::||.||
 Worm   502 VSPIFTQWLDCIWQIMQQKPRAFQFNERYLIEMHEHVYSCQFGTFIGNCDKDRRDLNLSKRTKSL 566

  Fly   528 WGYMANHLNEYINPLYKPNVDEAIKANLAPQCIKF--WRGMYSRFESGIHPREPLGDVLLDSKEH 590
            |.:|....::|:||.|.|....|: .:|..:..:|  |..||:||::|:.|||.|.|:.:.:.||
 Worm   567 WTWMDARHDDYMNPFYSPTAHVAL-LDLDTRAARFTVWTAMYNRFDNGLQPRERLEDLTMAAMEH 630

  Fly   591 CNSLEDHVQHLTKRIASFKNYISKSAKKLQDATSAPGKVNKELSSNEINDNKYNYDKKLSELSAA 655
            ...||.||..|..|:|..|.                 :.|::::|.....|..:     |.:|:|
 Worm   631 VGVLESHVAQLRTRLAELKT-----------------QQNQQITSTNTPTNMVD-----SGMSSA 673

  Fly   656 DDD-------HPLKASNMSFASLSLSAEQSS---------PPQALPEEINSVAVDWKPMRNVTTC 704
            .||       |||...:.:...|..:..|.|         |.:||    ...::.|:|:|....|
 Worm   674 TDDLKNLSLSHPLDPLSSTLPILERATSQESGVMDSSLYYPDEAL----TKYSLKWQPLRGADRC 734

  Fly   705 S---CSTPFDQ-FSKKTHCWRCGDIFCERCI 731
            |   |...|.. ..::.||..||.|||.||:
 Worm   735 SNPACRGEFSSTIERRIHCHLCGMIFCRRCL 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	33/91 (36%)
		Myotub-related	179..514	CDD:284109	180/340 (53%)
		FYVE_MTMR_unchar	693..753	CDD:277277	16/43 (37%)
mtm-6	NP_871680.1	PH-like	117..209	CDD:388408	33/91 (36%)
		PTP-MTMR6-like	237..540	CDD:350380	163/303 (54%)
		FYVE	724..782	CDD:214499	16/42 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158645
Domainoid	1	1.000	401	1.000	Domainoid score	I371
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56848
Inparanoid	1	1.050	570	1.000	Inparanoid score	I576
Isobase	1	0.950	-	0	Normalized mean entropy	S1948
OMA	1	1.010	-	-		QHG49274
OrthoDB	1	1.010	-	-		D192248at33208
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	1	1.000	-	-		oto17980
orthoMCL	1	0.900	-	-		OOG6_101828
Panther	1	1.100	-	-	LDO	PTHR10807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1956
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890