DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and mtm-1

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_491531.2	Gene:	mtm-1 / 172148	WormBaseID:	WBGene00003475	Length:	588	Species:	Caenorhabditis elegans

Alignment Length:	562	Identity:	198/562 - (35%)
Similarity:	291/562 - (51%)	Gaps:	59/562 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 YNTKNPTV--------GTLYLTATHLIFVEPDSNK--ETWILHM---HVASIEKLPLSTTGSP-- 139
            :..||.|.        |.:.:|...::|:..|..|  |.|.|.:   .|:.|||:...||...
Worm    36 WTEKNVTYFGPLGKFPGKIVITRYRMVFLVGDGGKMYEQWKLDIPLGQVSRIEKVGRKTTSVAKR 100

  Fly   140 ------LLIRCKTFLSVTFVI-PKDSECHDVYTSLLKLFQPVSIN-KLYCFNYQPNKDDFPKNAG 196
                  ..|.||.:....|.. |..|:..:|..||.:...|:|.| .::...:........|: |
Worm   101 GDDNYGFTIYCKDYRVYRFTCNPASSDRKNVCDSLNRYAFPLSHNLPMFASVHAAETPRLMKD-G 164

  Fly   197 WDYFKLEAEFKHMLVPN-EAWTLCSMNEKYELCDTYPRQIYVPK---EATTLMLISSSRFRSKGR 257
            |..:..|.|::.:.:|| ..|....:|:.|:..:||||...:|.   |.....:.....||||.|
Worm   165 WKIYSAEKEYERLGIPNSRLWKEVDINKDYKFSETYPRTFVIPTVSWEEGKPFVKKLGEFRSKER 229

  Fly   258 LPVLTYLHNNK-ASICRCSQPLSGFSA-RCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANR 320
            :|||::::... |||.|||||::|.|. |..|||:.|..|...|:|...:.::|.||.:||..|:
Worm   230 IPVLSWINQTTLASISRCSQPMTGISGKRSAEDERHLTNIMNANANCRELLILDARPAVNAKLNK 294

  Fly   321 AAGKGYENEAFYENIKFHFLGIENIHVQRASLQKVLEA----CEQKSPTMSAFINALESSGWLKH 381
            |.|.|||..  |.|....||.|.||||.|.||:::|.|    .::|     .:..||:.|.||.|
Worm   295 AKGGGYEEN--YVNAPLTFLNIHNIHVVRDSLKRLLAALIPRVDEK-----GYYKALDESKWLNH 352

  Fly   382 IRSILDTS-SFIANAVDKGVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAF 445
            ::|||:.: ..:.|...:..||::|||||||||||:.|||.:.|:.|||||:||..||||:|.:|
Worm   353 VQSILEGAVKAVFNVDTEKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWCSF 417

  Fly   446 GHKFSERCGHIQTDAR--EVSPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFV 508
            ||||.||.||...:..  |.||:|.||.||.||:|.|...||||.:..|:.:.|.:::|::|||:
Worm   418 GHKFGERIGHGDDNYSDGERSPVFVQFCDCLWQIMRQFPWAFEFTQELLICMLDELYACRYGTFL 482

  Fly   509 GNCEKDRL-DLKLAERTFSLWGYMANHLNEYINPLYKPNVDEAIKANLAPQ-C-IKFWRGMYSRF 570
            .|.||.|| |.|..|.|.|.|.|:..:..::.||::|......: .|:.|. | :..|...|:|.
Worm   483 YNSEKIRLKDKKCDETTISFWSYVLENKKKFRNPMFKHGKSNKV-INVNPSLCGLHVWIDYYARS 546

  Fly   571 ESGI----HP--REPLGDVLLDSK----EHCNSLEDHVQHLT 602
            ...:    |.  ::| |...:|.|    :...:|:|..|.||
Worm   547 NPYVVTPNHEDVQQP-GAQFVDEKKQLLDEIMALDDAAQKLT 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	26/104 (25%)
		Myotub-related	179..514	CDD:284109	140/347 (40%)
		FYVE_MTMR_unchar	693..753	CDD:277277
mtm-1	NP_491531.2	PH-GRAM_MTM-like	36..141	CDD:275407	26/104 (25%)
mtm-1	NP_491531.2	Myotub-related	148..487	CDD:284109	139/346 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1956
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950