Protein Alignment Mtmr6 and Mtmr4

DIOPT Version :10

• Sequence 1: NP_726322.1
• Gene: Mtmr6 / 37707
• FlyBaseID: FBgn0028497
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_001389523.1
• Gene: Mtmr4 / 170749
• MGIID: 2180699
• Length: 1204
• Species: Mus musculus
• Alignment Length: 795
• Identity: 221/795 - (27%)
• Similarity: 342/795 - (43%)
• Gaps: 197/795 - (24%)

  Fly    24 RLSFDNISPETEEPPDGNKRLWGVPV-PPFVSEKVVSWIEEEFNEAPVFYNGNSVLKKVENVRMI 87
            |:|...:|...||.|...:.:....: ||   :::|.  |||..:.|.     :||:. |.|..:
Mouse     6 RVSCSMLSCFGEEGPPSLEYIQAKDLFPP---KELVK--EEENLQVPF-----TVLQG-EGVEFL 59

  Fly    88 DRYNTKNPTVGTLYLTATHLIFVEP---------DSNKETWILHMHVASIEKLPLSTTGSPLLIR 143
            .|.......:....|   |:.|.:.         ||.:...:..:|:|..:.         .::|
Mouse    60 GRATDALIAISNYRL---HIKFKDSVINVPLRMIDSVESRDMFQLHIACKDS---------KVVR 112

  Fly   144 C--KTFLSVTFVIPKDSECHDVYTSLLK-LFQPVSINKLYCFNYQPNKDDFPKNAGWDY-FKLEA 204
            |  .||          .:|.:..:.|.: ..:|.....|:.|.|.          .|.. ...|.
Mouse   113 CHFSTF----------KQCQEWLSRLSRATARPAKPEDLFAFAYH----------AWCLGLTEED 157

  Fly   205 EFKHMLVPNE-------------------AWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSS 250
            :..|:..|.|                   .|.:..:|..|:||.:||:::.||...|...|.:.:
Mouse   158 QHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVA 222

  Fly   251 RFRSKGRLPVLTYLH-NNKASICRCSQP-LSGFSARCLEDEQMLEAIRK---------------- 297
            .|||..|:||:.|.| .|.|:|.||||| :|.:..|..:||.::.:|.|
Mouse   223 SFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRASGGSLS 287

  Fly   298 --TNS-----NTDY------------------MYVVDTRPRINAMANRAAGKGYENEAFYENIKF 337
              ||.     :||:                  :.::|.|....|:||||.|.|.|.|.:|.|.:.
Mouse   288 TGTNDASEACDTDFDSSLTACSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEV 352

  Fly   338 HFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDK-GVS 401
            .|:|:.|||..|.|.|.:...|.| .|..|.:::||||:.||:|:..:|..:..:||.||: |..
Mouse   353 LFMGMANIHAIRNSFQYLRAVCSQ-MPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRP 416

  Fly   402 VVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHIQT--DAREVS 464
            |:||||||||||.|:.:||:::|:|||||::|||.|:|.|||.|||||.:||||.:.  |..|..
Mouse   417 VLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENAEDQNEQC 481

  Fly   465 PIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGN--CEKDRLDLKLAERTFSL 527
            |:|.|:||...||:.|....|||||.||:.|..|.:||.:|||:.|  ||:::.:  :.:||.|:
Mouse   482 PVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRN--IYKRTCSV 544

  Fly   528 WGYMANHLNEYINPLYKPNVDEAIKANLAPQCIKFWRGMYSRFESGIHPREPLGDVLLDSKEHCN 592
            |..:......:.|.||.|..|..:......:.:..|..:|                 |.:...|.
Mouse   545 WALLRAGNKNFHNFLYTPGSDVVLHPVCHVRALHLWTAVY-----------------LPASSPCT 592

  Fly   593 SLEDHVQHLTKRIASFKNYISKSAKKLQDATSAPGKVNKELSSNEINDNKYNYDKKLSELSAADD 657
            ..|:::......:|..:.:..:|..:|.          |..|.:::             |||.|.
Mouse   593 LGEENMDLYLSPVAQSQEFSGRSLDRLP----------KTRSMDDL-------------LSACDT 634

  Fly   658 DHPLKAS----NMSFASL----SLSAEQSSP-------------PQ------ALPEEINSVAVDW 695
            ..||..:    |::..|.    ||....|||             ||      .||..:.|...::
Mouse   635 SSPLTRTSSDPNLNNHSQEVRGSLEPWHSSPEGAETVIDSGVGSPQLTVGEMGLPPPLPSSQKEY 699

  Fly   696 ---KPMRNVTTCSCS 707
               ||.:...:||.|
Mouse   700 LSNKPFKGHKSCSLS 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtmr6	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	17/106 (16%)
		PTP-MTMR6-like	202..501	CDD:350380	135/363 (37%)
		FYVE_MTMR_unchar	693..753	CDD:277277	5/18 (28%)
Mtmr4	NP_001389523.1	PH-GRAM_MTMR4	37..150	CDD:270150	27/152 (18%)
		PTP-MTMR4	186..493	CDD:350435	119/307 (39%)
		FYVE_MTMR4	1120..1179	CDD:277272