DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3530 and Mtmr4

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_006532446.1	Gene:	Mtmr4 / 170749	MGIID:	2180699	Length:	1204	Species:	Mus musculus

Alignment Length:	795	Identity:	221/795 - (27%)
Similarity:	342/795 - (43%)	Gaps:	197/795 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RLSFDNISPETEEPPDGNKRLWGVPV-PPFVSEKVVSWIEEEFNEAPVFYNGNSVLKKVENVRMI 87
            |:|...:|...||.|...:.:....: ||   :::|.  |||..:.|.     :||:. |.|..:
Mouse     6 RVSCSMLSCFGEEGPPSLEYIQAKDLFPP---KELVK--EEENLQVPF-----TVLQG-EGVEFL 59

  Fly    88 DRYNTKNPTVGTLYLTATHLIFVEP---------DSNKETWILHMHVASIEKLPLSTTGSPLLIR 143
            .|.......:....|   |:.|.:.         ||.:...:..:|:|..:.         .::|
Mouse    60 GRATDALIAISNYRL---HIKFKDSVINVPLRMIDSVESRDMFQLHIACKDS---------KVVR 112

  Fly   144 C--KTFLSVTFVIPKDSECHDVYTSLLK-LFQPVSINKLYCFNYQPNKDDFPKNAGWDY-FKLEA 204
            |  .||          .:|.:..:.|.: ..:|.....|:.|.|.          .|.. ...|.
Mouse   113 CHFSTF----------KQCQEWLSRLSRATARPAKPEDLFAFAYH----------AWCLGLTEED 157

  Fly   205 EFKHMLVPNE-------------------AWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSS 250
            :..|:..|.|                   .|.:..:|..|:||.:||:::.||...|...|.:.:
Mouse   158 QHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVA 222

  Fly   251 RFRSKGRLPVLTYLH-NNKASICRCSQP-LSGFSARCLEDEQMLEAIRK---------------- 297
            .|||..|:||:.|.| .|.|:|.||||| :|.:..|..:||.::.:|.|
Mouse   223 SFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRASGGSLS 287

  Fly   298 --TNS-----NTDY------------------MYVVDTRPRINAMANRAAGKGYENEAFYENIKF 337
              ||.     :||:                  :.::|.|....|:||||.|.|.|.|.:|.|.:.
Mouse   288 TGTNDASEACDTDFDSSLTACSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEV 352

  Fly   338 HFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDK-GVS 401
            .|:|:.|||..|.|.|.:...|.| .|..|.:::||||:.||:|:..:|..:..:||.||: |..
Mouse   353 LFMGMANIHAIRNSFQYLRAVCSQ-MPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRP 416

  Fly   402 VVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHIQT--DAREVS 464
            |:||||||||||.|:.:||:::|:|||||::|||.|:|.|||.|||||.:||||.:.  |..|..
Mouse   417 VLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENAEDQNEQC 481

  Fly   465 PIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGN--CEKDRLDLKLAERTFSL 527
            |:|.|:||...||:.|....|||||.||:.|..|.:||.:|||:.|  ||:::.:  :.:||.|:
Mouse   482 PVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRN--IYKRTCSV 544

  Fly   528 WGYMANHLNEYINPLYKPNVDEAIKANLAPQCIKFWRGMYSRFESGIHPREPLGDVLLDSKEHCN 592
            |..:......:.|.||.|..|..:......:.:..|..:|                 |.:...|.
Mouse   545 WALLRAGNKNFHNFLYTPGSDVVLHPVCHVRALHLWTAVY-----------------LPASSPCT 592

  Fly   593 SLEDHVQHLTKRIASFKNYISKSAKKLQDATSAPGKVNKELSSNEINDNKYNYDKKLSELSAADD 657
            ..|:::......:|..:.:..:|..:|.          |..|.:::             |||.|.
Mouse   593 LGEENMDLYLSPVAQSQEFSGRSLDRLP----------KTRSMDDL-------------LSACDT 634

  Fly   658 DHPLKAS----NMSFASL----SLSAEQSSP-------------PQ------ALPEEINSVAVDW 695
            ..||..:    |::..|.    ||....|||             ||      .||..:.|...::
Mouse   635 SSPLTRTSSDPNLNNHSQEVRGSLEPWHSSPEGAETVIDSGVGSPQLTVGEMGLPPPLPSSQKEY 699

  Fly   696 ---KPMRNVTTCSCS 707
               ||.:...:||.|
Mouse   700 LSNKPFKGHKSCSLS 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	17/106 (16%)
		Myotub-related	179..514	CDD:284109	147/402 (37%)
		FYVE_MTMR_unchar	693..753	CDD:277277	5/18 (28%)
Mtmr4	XP_006532446.1	PH-GRAM_MTMR4	37..150	CDD:270150	27/152 (18%)
		PTP-MTMR4	186..493	CDD:350435	119/307 (39%)
		Atrophin-1	743..>863	CDD:367360
		FYVE_MTMR4	1120..1179	CDD:277272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846026
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824298at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850