Protein Alignment Mtmr6 and MTMR11

DIOPT Version :10

• Sequence 1: NP_726322.1
• Gene: Mtmr6 / 37707
• FlyBaseID: FBgn0028497
• Length: 761
• Species: Drosophila melanogaster
• Sequence 2: NP_001139334.1
• Gene: MTMR11 / 10903
• HGNCID: 24307
• Length: 709
• Species: Homo sapiens
• Alignment Length: 648
• Identity: 156/648 - (24%)
• Similarity: 242/648 - (37%)
• Gaps: 203/648 - (31%)

  Fly    29 NISPETEEPPDGNKRLWGVPVPP------------FVSEKVVSWIEEEFNEAPVFYNGNSVLKKV 81
            ||:|:.|||..|:.:...:|.|.            ...|::::|       ||      .|.|.:
Human    11 NIAPQKEEPEMGSVQENRMPEPRSRQPSSCLASRCLPGEQILAW-------AP------GVRKGL 62

  Fly    82 ENVRMIDRYNTKNPTV-GTLYLTATHLIFVEP---DSNKETWILHMH------------VASIEK 130
            |            |.: |||..|...:.| :|   ..|::|.:...:            |:.:.:
Human    63 E------------PELSGTLICTNFRVTF-QPCGWQWNQDTPLNSEYDFALVNIGRLEAVSGLSR 114

  Fly   131 LPLSTTGS-------PLLIRCKTF----------------LSVTFVIPK---DSECHDVYT--SL 167
            :.|...||       .:||..:.|                ..||..|.:   .|.....|:  :|
Human   115 VQLLRPGSLHKFIPEEILIHGRDFRLLRVGFEAGGLEPQAFQVTMAIVQARAQSNQAQQYSGITL 179

  Fly   168 LKLFQ-------PVSINKLYCFNYQPNKDDFPKNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKY 225
            .|..|       |:.:        ....:|      |     |.|.|....  ..|.:.::||::
Human   180 SKAGQGSGSRKPPIPL--------METAED------W-----ETERKKQAA--RGWRVSTVNERF 223

  Fly   226 ELCDTYPRQIYVPKEATTLMLISSSRFR------SKGRLPVLTYLHNNKASICRCSQPLSGF--- 281
            ::..:.||..:||..      |..|..|      .:||.|.|::.|...:.:.||    .||
Human   224 DVATSLPRYFWVPNR------ILDSEVRRAFGHFHQGRGPRLSWHHPGGSDLLRC----GGFYTA 278

  Fly   282 SARCLED----EQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYENIKFHFLGI 342
            |....||    |.||:|     .::| :.:|||...:.::|:
Human   279 SDPNKEDIRAVELMLQA-----GHSD-VVLVDTMDELPSLAD----------------------- 314

  Fly   343 ENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDKGV-SVVVHC 406
                ||.|.|:.........|.....:::|||.:.||.::|:.|..:|.|:..|...| ||::..
Human   315 ----VQLAHLRLRALCLPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQE 375

  Fly   407 SDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHIQTDAREVSPIFTQFL 471
            ....|....:.||.||:..|..||:.|||:|::::|:|.||.|..|.|  .|.|.|.:|:|..||
Human   376 RGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLG--GTGASEEAPVFLLFL 438

  Fly   472 DCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGYMANHLN 536
            ||.|||:.|....|||:|.|||.|||.|......||:.|...:|             |..:..||
Human   439 DCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWER-------------GKQSGQLN 490

  Fly   537 EYINPLYKPNVDEAIKANLAPQCIKFW-------RGMYSRFES-GIHPREPLGDVLLDSKEHC 591
            .| ..:|.|...:....|.....:..|       .....:|:: |..|            |||
Human   491 SY-TQVYTPGYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGYDP------------EHC 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtmr6	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	26/145 (18%)
		PTP-MTMR6-like	202..501	CDD:350380	95/312 (30%)
		FYVE_MTMR_unchar	693..753	CDD:277277
MTMR11	NP_001139334.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		9/27 (33%)
		PH-like	46..160	CDD:473070	25/139 (18%)
		PTP_DSP_cys	254..444	CDD:475123	68/228 (30%)
		3-PAP	551..678	CDD:463634