DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and MTMR11

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	NP_001139334.1	Gene:	MTMR11 / 10903	HGNCID:	24307	Length:	709	Species:	Homo sapiens

Alignment Length:	648	Identity:	156/648 - (24%)
Similarity:	242/648 - (37%)	Gaps:	203/648 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NISPETEEPPDGNKRLWGVPVPP------------FVSEKVVSWIEEEFNEAPVFYNGNSVLKKV 81
            ||:|:.|||..|:.:...:|.|.            ...|::::|       ||      .|.|.:
Human    11 NIAPQKEEPEMGSVQENRMPEPRSRQPSSCLASRCLPGEQILAW-------AP------GVRKGL 62

  Fly    82 ENVRMIDRYNTKNPTV-GTLYLTATHLIFVEP---DSNKETWILHMH------------VASIEK 130
            |            |.: |||..|...:.| :|   ..|::|.:...:            |:.:.:
Human    63 E------------PELSGTLICTNFRVTF-QPCGWQWNQDTPLNSEYDFALVNIGRLEAVSGLSR 114

  Fly   131 LPLSTTGS-------PLLIRCKTF----------------LSVTFVIPK---DSECHDVYT--SL 167
            :.|...||       .:||..:.|                ..||..|.:   .|.....|:  :|
Human   115 VQLLRPGSLHKFIPEEILIHGRDFRLLRVGFEAGGLEPQAFQVTMAIVQARAQSNQAQQYSGITL 179

  Fly   168 LKLFQ-------PVSINKLYCFNYQPNKDDFPKNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKY 225
            .|..|       |:.:        ....:|      |     |.|.|....  ..|.:.::||::
Human   180 SKAGQGSGSRKPPIPL--------METAED------W-----ETERKKQAA--RGWRVSTVNERF 223

  Fly   226 ELCDTYPRQIYVPKEATTLMLISSSRFR------SKGRLPVLTYLHNNKASICRCSQPLSGF--- 281
            ::..:.||..:||..      |..|..|      .:||.|.|::.|...:.:.||    .||
Human   224 DVATSLPRYFWVPNR------ILDSEVRRAFGHFHQGRGPRLSWHHPGGSDLLRC----GGFYTA 278

  Fly   282 SARCLED----EQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYENIKFHFLGI 342
            |....||    |.||:|     .::| :.:|||...:.::|:
Human   279 SDPNKEDIRAVELMLQA-----GHSD-VVLVDTMDELPSLAD----------------------- 314

  Fly   343 ENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAVDKGV-SVVVHC 406
                ||.|.|:.........|.....:::|||.:.||.::|:.|..:|.|:..|...| ||::..
Human   315 ----VQLAHLRLRALCLPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQE 375

  Fly   407 SDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHIQTDAREVSPIFTQFL 471
            ....|....:.||.||:..|..||:.|||:|::::|:|.||.|..|.|  .|.|.|.:|:|..||
Human   376 RGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLG--GTGASEEAPVFLLFL 438

  Fly   472 DCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGYMANHLN 536
            ||.|||:.|....|||:|.|||.|||.|......||:.|...:|             |..:..||
Human   439 DCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWER-------------GKQSGQLN 490

  Fly   537 EYINPLYKPNVDEAIKANLAPQCIKFW-------RGMYSRFES-GIHPREPLGDVLLDSKEHC 591
            .| ..:|.|...:....|.....:..|       .....:|:: |..|            |||
Human   491 SY-TQVYTPGYSQPPAGNSFNLQLSVWDWDLRYSNAQILQFQNPGYDP------------EHC 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	26/145 (18%)
		Myotub-related	179..514	CDD:284109	100/348 (29%)
		FYVE_MTMR_unchar	693..753	CDD:277277
MTMR11	NP_001139334.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		9/27 (33%)
		PH-like	46..160	CDD:302622	25/139 (18%)
		PTPc	201..466	CDD:304379	96/322 (30%)
		3-PAP	551..678	CDD:289355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155584
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1089
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740