DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and mtmr8

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_004915812.2	Gene:	mtmr8 / 100489239	XenbaseID:	XB-GENE-948866	Length:	676	Species:	Xenopus tropicalis

Alignment Length:	591	Identity:	308/591 - (52%)
Similarity:	404/591 - (68%)	Gaps:	14/591 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KVENVRMIDRYNTKNPTVGTLYLTATHLIFVEP--DSNKETWILHMHVASIEKLPLSTTGSPLLI 142
            |||||::.|||..|.|.||||||||||||:||.  .:.|||||.|.|::.:|||.|:|||.||:|
Frog     8 KVENVKLFDRYTNKRPAVGTLYLTATHLIYVESGVGARKETWIPHHHISLVEKLALNTTGCPLVI 72

  Fly   143 RCKTFLSVTFVIPKDSECHDVYTSLLKLFQPVSINKLYCFNYQPNKDDFPKNAGWDYFKLEAEFK 207
            |||.|.:..|||.::.:||.||||||||.||.....||.|:|.|:.|...:..||....||.||.
Frog    73 RCKNFRAAHFVIQRERDCHKVYTSLLKLSQPAKYEDLYAFSYNPSHDKDERAVGWKQVDLEVEFL 137

  Fly   208 HMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLT-YLHNNKASI 271
            .|.:|||.|.|..:|:.|::|.|||..:.|||||....::.|::|||:||.|||: |..:|.|.|
Frog   138 RMGIPNEFWKLTDLNKDYKVCSTYPTCLVVPKEANEATILGSAKFRSRGRFPVLSYYFKDNNAVI 202

  Fly   272 CRCSQPLSGFSARCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYENIK 336
            ||||||||||||||.:||:|||.|.|.|..:.:||||||||::|||||||||||||||..|.||:
Frog   203 CRCSQPLSGFSARCEDDEKMLETIGKANPGSPFMYVVDTRPKLNAMANRAAGKGYENEDNYPNIR 267

  Fly   337 FHFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAV-DKGV 400
            |.|:|||||||.|.||||:||.||.|||:||.|:..||:||||:||::::|...|:|..| |:..
Frog   268 FKFIGIENIHVMRNSLQKLLEVCEMKSPSMSNFLTVLENSGWLRHIKAVMDAGVFLAKVVQDENA 332

  Fly   401 SVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHIQTDAREVSP 465
            ||:|||||||||||||||||.::|:|:|||||||..||||:|::.||||::||||:..|.:||||
Frog   333 SVLVHCSDGWDRTAQVCSLASILLDPFYRTIKGFMFLIEKEWISLGHKFTQRCGHLDVDPKEVSP 397

  Fly   466 IFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGY 530
            :||||::|.|.|..|...||||:|||||.:|||:.|||||.|:||.:|:|.:||:.|||.|||.:
Frog   398 VFTQFVECVWHLTEQFPCAFEFSERFLLEIHDHIFSCQFGNFIGNSQKEREELKIFERTHSLWQF 462

  Fly   531 MANHLNEYINPLYKPNVDEAIKANLAPQCIKFWRGMYSRFESGIHPREPLGDVLLDSKEHCNSLE 595
            :.....|::||||.....:.::....|...|||.|||:||:.|:|||:.:.|.||:......:||
Frog   463 LLQRKQEFVNPLYTHLAYKTLRPITLPFTFKFWCGMYNRFDKGMHPRQCVLDYLLECMNKKAALE 527

  Fly   596 DHVQHLTKRIASFKNYISKSAKK-----LQDATSAPGKVNKELSSNEINDNKYNYDKKLSELSAA 655
            ........::|: :::..|....     ||...:.....||::......:.|.    :||..|..
Frog   528 KSEIEAENKLAA-QDFPEKKGPSVLSVHLQTVPTTEVMANKDIPELSKEETKC----QLSNGSMT 587

  Fly   656 DDDHPL 661
            |.||.|
Frog   588 DSDHNL 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	58/94 (62%)
		Myotub-related	179..514	CDD:284109	201/336 (60%)
		FYVE_MTMR_unchar	693..753	CDD:277277
mtmr8	XP_004915812.2	PH-like	1..103	CDD:418428	58/94 (62%)
mtmr8	XP_004915812.2	PTP-MTMR8	126..433	CDD:350432	187/306 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	450	1.000	Domainoid score	I512
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56848
Inparanoid	1	1.050	631	1.000	Inparanoid score	I829
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192248at33208
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	1	1.000	-	-		otm49031
Panther	1	1.100	-	-	O	PTHR10807
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160