DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3530 and mtmr7

DIOPT Version :9

Sequence 1:	NP_726322.1	Gene:	CG3530 / 37707	FlyBaseID:	FBgn0028497	Length:	761	Species:	Drosophila melanogaster
Sequence 2:	XP_004911249.1	Gene:	mtmr7 / 100485851	XenbaseID:	XB-GENE-1008662	Length:	657	Species:	Xenopus tropicalis

Alignment Length:	682	Identity:	320/682 - (46%)
Similarity:	443/682 - (64%)	Gaps:	57/682 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LKKVENVRMIDRYNTKNPTVGTLYLTATHLIFVE--PDSNKETWILHMHVASIEKLPLSTTGSPL 140
            |.||||||::||.:::...:||||||.||:||||  .::.||||||:..::||||...:|:|.|:
Frog     6 LPKVENVRLLDRISSRKAALGTLYLTGTHIIFVENISETRKETWILYSQISSIEKQATATSGCPI 70

  Fly   141 LIRCKTFLSVTFVIPKDSECHDVYTSLLKLFQPVSINKLYCFNYQPNKDDFPKNAGWDYFKLEAE 205
            ||.||.|..:..:||::.:|||:|.||::|.:||...:||||:::||.|......||....|..|
Frog    71 LIHCKNFQVIQLIIPQERDCHDIYLSLVRLSRPVKYEELYCFSFKPNLDKTEHEEGWKLVDLNEE 135

  Fly   206 FKHMLVPNEAWTLCSMNEKYELCDTYPRQIYVPKEATTLMLISSSRFRSKGRLPVLT-YLHNNKA 269
            :..|.:|...|.:..:|..|.:||:||.::||||.||..:::.||:|||:||.|.|: |..:|.|
Frog   136 YNRMGLPKSLWQMSDVNRDYRVCDSYPTELYVPKSATVPIIVGSSKFRSRGRFPTLSYYCQDNNA 200

  Fly   270 SICRCSQPLSGFSARCLEDEQMLEAIRKTNSNTDYMYVVDTRPRINAMANRAAGKGYENEAFYEN 334
            ||||.||||||||||||||||||:||||.|..:|::|||||||::|||||||||||||||..|.:
Frog   201 SICRSSQPLSGFSARCLEDEQMLQAIRKANPGSDFLYVVDTRPKLNAMANRAAGKGYENEDNYSD 265

  Fly   335 IKFHFLGIENIHVQRASLQKVLEACEQKSPTMSAFINALESSGWLKHIRSILDTSSFIANAV-DK 398
            |||.|:|||||||.|.||||:||.||.:||:|..|:..||||||||||::|:|...|||.|| ::
Frog   266 IKFQFIGIENIHVMRNSLQKMLEVCELRSPSMGDFLWGLESSGWLKHIKAIIDAGIFIAKAVSEE 330

  Fly   399 GVSVVVHCSDGWDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHIQTDAREV 463
            |.||:|||||||||||||||:|.|:::|||||||||..||||||::|||||:.|.|::..|.:||
Frog   331 GASVLVHCSDGWDRTAQVCSIASLLIDPYYRTIKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEV 395

  Fly   464 SPIFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLW 528
            ||:..||::|.||||.|...|||||||||:.:|.||:|||:|.|:.||:|:|.::::.|||:|||
Frog   396 SPVIDQFIECVWQLMEQFPCAFEFNERFLVHIHHHVYSCQYGNFLCNCQKERREIRVQERTYSLW 460

  Fly   529 GYMANHLNEYINPLYKPNVDE---AIKANLAPQCIKFWRGMYSRFESGIHPREPLGDVLLDSKEH 590
            .|:.....:|:||||:.:..:   .::.|.:|...|||||:|:|||.|:.||:.:.|.|...||.
Frog   461 SYLWKQRLDYMNPLYRADHSQTQGTLRPNTSPSNFKFWRGLYNRFEKGMQPRQSVTDFLQAVKEE 525

  Fly   591 CNSLEDHVQHLTKRIASFKNYISKSAKKLQDATSAPGKVNKELSSNEINDNKYNYDKK---LSEL 652
            ...||:.::.:.||...|::.                .:|...|.|||:::    ||.   .:..
Frog   526 TQQLEEELEFMQKRWQKFESQ----------------HLNGTKSFNEIHES----DKLQICATAY 570

  Fly   653 SAADDDHPLKASNMSFASLSLS-AEQSSPPQALPEEINS----VAVDWKPMRNVTTCSCSTPFDQ 712
            ::|:......::..||.|.|.| .|:.|......|.:.|    ::.:......|...||.:|..
Frog   571 TSANSPQDYSSTLKSFPSRSPSQGEEDSALILTQEHLKSSDPDLSANSDQESGVEDLSCRSPSG- 634

  Fly   713 FSKKTHCWRCGDIFCERCIDKNVALPGHDSGK 744
                      ||           :||..||||
Frog   635 ----------GD-----------SLPSEDSGK 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3530	NP_726322.1	PH-GRAM_MTMR6-like	78..173	CDD:270030	48/96 (50%)
		Myotub-related	179..514	CDD:284109	204/336 (61%)
		FYVE_MTMR_unchar	693..753	CDD:277277	12/52 (23%)
mtmr7	XP_004911249.1	PH-GRAM_MTMR7	1..103	CDD:270152	48/96 (50%)
mtmr7	XP_004911249.1	PTP-MTMR7	132..433	CDD:350431	188/300 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	450	1.000	Domainoid score	I512
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	631	1.000	Inparanoid score	I829
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192248at33208
OrthoFinder	1	1.000	-	-		FOG0000303
OrthoInspector	1	1.000	-	-		otm49031
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X213
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060