Protein Alignment eIF2Bdelta and EIF2B2

DIOPT Version :10

• Sequence 1: NP_611790.1
• Gene: eIF2Bdelta / 37706
• FlyBaseID: FBgn0034858
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_055054.1
• Gene: EIF2B2 / 8892
• HGNCID: 3258
• Length: 351
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 82/307 - (26%)
• Similarity: 136/307 - (44%)
• Gaps: 58/307 - (18%)

  Fly   313 RLGVQYAKRTVVGSNARCIAFLHALRQVVHDFETPAKKEFGR---SLDAAVKHHVDHLHKCRPLA 374
            |:.......|.||:..|.:  |..:|:           |:||   ..|.:.:.  :.|||    .
Human    67 RMTAAQPSETTVGNMVRRV--LKIIRE-----------EYGRLHGRSDESDQQ--ESLHK----L 112

  Fly   375 VSVSNAYKQFKNQLTQLPADVPETESKELLVHFIDTYIENQIGKAAQAISGFLQEKITDGDVLLT 439
            ::.....:.|.....||.:::.|. ..||||....| :||   .||||:     |.|...:|::|
Human   113 LTSGGLNEDFSFHYAQLQSNIIEA-INELLVELEGT-MEN---IAAQAL-----EHIHSNEVIMT 167

  Fly   440 FACSSLIQFICEEAKRRQVAFRVIVVDSRPGCEGQELLRRLHATGIPCTYVLINAVGYVMAEATK 504
            ...|..::...:||.|:: .|.|||.:..|.|:|.|:...|...||..|.:...|:..||:...|
Human   168 IGFSRTVEAFLKEAARKR-KFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNK 231

  Fly   505 VLLGAHALLANGYVMARTGTAQVALVANAHNVPVLVCCETHKFSERFQTDAIVYNELSDPNQLV- 568
            |::|...:||||.:.|.|||..:||.|..|:.|::||....|.|.:|..:...:::...|.:::
Human   232 VIIGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLP 296

  Fly   569 --RGD-------KCQLSNWAAKGKLLPLNLSYDITPPELVSAVVTEV 606
              .||       .|.:               :|..||||::..::.:
Human   297 FTEGDILEKVSVHCPV---------------FDYVPPELITLFISNI 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bdelta	NP_611790.1	IF-2B	323..611	CDD:395798	80/297 (27%)
EIF2B2	NP_055054.1	IF-2B	29..333	CDD:395798	82/307 (27%)