DRSC/TRiP Functional Genomics Resources

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Protein Alignment eIF2Bdelta and EIF2B4

DIOPT Version :9

Sequence 1:NP_611790.1 Gene:eIF2Bdelta / 37706 FlyBaseID:FBgn0034858 Length:626 Species:Drosophila melanogaster
Sequence 2:NP_001305894.1 Gene:EIF2B4 / 8890 HGNCID:3260 Length:544 Species:Homo sapiens


Alignment Length:557 Identity:233/557 - (41%)
Similarity:318/557 - (57%) Gaps:58/557 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 PSAPATKIITEVEQTTITTKLTTTTTTKVQDAVASKTTQPAAVNGKDAEAGEKTREQ-IKAEREA 164
            |:||:|:      ....:..|:.:......||.:....:.....|..|...|.|:|: ::..:|.
Human     6 PAAPSTR------APKPSRSLSGSLCALFSDADSGSGMKAELPPGPGAVGREMTKEEKLQLRKEK 64

  Fly   165 KKAAKKAGKGGGAKVE-GIAQQLADLKVAEKAPVAASAAPSTTEADQEKKKPALSK----AERRA 224
            |:..||..:..||:.| |.|...|..:|.....:..|.....|  .:||.....||    |||||
Human    65 KQQKKKRKEEKGAEPETGSAVSAAQCQVGPTRELPESGIQLGT--PREKVPAGRSKAELRAERRA 127

  Fly   225 IQEAQRAAKAQVQTKKAQHAAKAPPSAAPKGPNRKSVSPTTAATSSSPVKCPASTPNVD------ 283
            .|||:||.|   |.:|.:... .||.|          ||:||..:.|.||.....|.||      
Human   128 KQEAERALK---QARKGEQGG-PPPKA----------SPSTAGETPSGVKRLPEYPQVDDLLLRR 178

  Fly   284 -----------------CRVKLFNHL-VCAKEDS--QFINDP--LVHPSIARLGVQYAKRTVVGS 326
                             .:|.||:|| ..::::|  ||::.|  ::||::.|||:||::..|.||
Human   179 LVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGS 243

  Fly   327 NARCIAFLHALRQVVHDFETPAKKEFGRSLDAAVKHHVDHLHKCRPLAVSVSNAYKQFKNQLTQL 391
            ||||||.|.||:||:.|:.||..:|..|.|...:|.::..|.:||||:.|:.||.|....::|.:
Human   244 NARCIALLRALQQVIQDYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSV 308

  Fly   392 PADVPETESKELLVHFIDTYIENQIGKAAQAISGFLQEKITDGDVLLTFACSSLIQFICEEAKRR 456
            .:...|.|:|..|...||.|::.:|..||||||.|..:||::|||:|.:.||||:..|.:||...
Human   309 GSSKREEEAKSELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTE 373

  Fly   457 QVAFRVIVVDSRPGCEGQELLRRLHATGIPCTYVLINAVGYVMAEATKVLLGAHALLANGYVMAR 521
            ...|||:||||||..||:..||.|...|:|.:|:||.|..||:.|.:|||||||||||||.||:|
Human   374 GRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSR 438

  Fly   522 TGTAQVALVANAHNVPVLVCCETHKFSERFQTDAIVYNELSDPN--QLVRGDKCQLSNWAAKGKL 584
            .||||:||||.||||||||||||:||.||.||||.|.|||.||:  |..||:...|:||.....|
Human   439 VGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASL 503

  Fly   585 LPLNLSYDITPPELVSAVVTEVAILPCTSVPVILRIK 621
            ..|||.||:||||||..|:||:.::||:||||:||:|
Human   504 RLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVK 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eIF2BdeltaNP_611790.1 GCD2 306..619 CDD:224105 166/314 (53%)
IF-2B 323..611 CDD:279362 153/289 (53%)
EIF2B4NP_001305894.1 GCD2 240..538 CDD:224105 159/297 (54%)
IF-2B 240..530 CDD:279362 153/289 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159284
Domainoid 1 1.000 292 1.000 Domainoid score I1520
eggNOG 1 0.900 - - E1_COG1184
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 359 1.000 Inparanoid score I2221
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54388
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003475
OrthoInspector 1 1.000 - - oto90543
orthoMCL 1 0.900 - - OOG6_101847
Panther 1 1.100 - - LDO PTHR10233
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R373
SonicParanoid 1 1.000 - - X2839
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.790

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