Protein Alignment eIF2Bdelta and GCD2

DIOPT Version :9

• Sequence 1: NP_611790.1
• Gene: eIF2Bdelta / 37706
• FlyBaseID: FBgn0034858
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_011597.1
• Gene: GCD2 / 852974
• SGDID: S000003315
• Length: 651
• Species: Saccharomyces cerevisiae
• Alignment Length: 672
• Identity: 181/672 - (26%)
• Similarity: 278/672 - (41%)
• Gaps: 148/672 - (22%)

  Fly    69 MAEREAK-KLAKQAKKQKTAPTPTAATPAVLTTPSAPATKIIT--EVEQTTITTKLTTTTTTKVQ 130
            |:|.||| :.|....|.|.| |||       ||.:|...|.:|  |:::.....|.......|..
Yeast     1 MSESEAKSRSATPPSKAKQA-TPT-------TTAAANGEKKLTNKELKELKKQEKAAKRAAMKQA 57

  Fly   131 DAVASKTTQPAAVNGKDAEAGEKTREQIKAEREAKKAAKKAGKGGGAK-------VEGIAQQLAD 188
            :.::.:..|..|...|:.:..::.::| |.|::.|.|.||.......|       :|...::.|.
Yeast    58 NGISIEQQQQQAQMKKEKKQLQREQQQ-KREQKQKNANKKKQNERNVKKSTLFGHLETTEERRAT 121

  Fly   189 LKVAEKA----------------PVAASA--------------------------APSTTEADQE 211
            :.....|                ||.|||                          ||::|.....
Yeast   122 ILALTSAVSSPKTSRITAAGLMVPVVASALSGSNVLTASSLMPVGPNASSTVSASAPASTTTTLP 186

  Fly   212 KKKPALSKAERRAIQEAQRAAKAQVQTKKAQHAAKAPPSAAPKG------PNRKSVSPTTAATSS 270
            ....|||.....|......|.:.::.:..|...||...|.:.:.      |...||.||....|.
Yeast   187 ASSAALSAGTSSASTNTPTAIQQEIASSNASDVAKTLASISLEAGEFNVIPGISSVIPTVLEQSF 251

  Fly   271 SPVKCPASTPNVDCRVKLFNHLVCAKEDSQFINDPLVHPSIARLGVQYAKRTVVGSNARCIAFLH 335
            .                  |..:.:......:|..|:||||..|....|...:|||..||||.|.
Yeast   252 D------------------NSSLISSVKELLLNKDLIHPSILLLTSHLAHYKIVGSIPRCIAMLE 298

  Fly   336 ALRQVVHDFETPAKKEFGRSLDAAVKHHVDHLHKCRPLAVSVSNAYKQFKNQLTQLPADVPETES 400
            ..:.|:.|::||......|:|.:.:.|.:|.|.|.|||:|::.||.:..|.:::.:....|:..:
Yeast   299 VFQIVIKDYQTPKGTTLSRNLTSYLSHQIDLLKKARPLSVTMGNAIRWLKQEISLIDPSTPDKAA 363

  Fly   401 KELLVHFIDTYIENQIGKAAQAISGFLQEKITDGDVLLTFACSS-LIQFICEEAKRRQVAFRVIV 464
            |:.|...|..:.:.:|..|.|.|......:|.:...::|:..|. |.:.:...|...:...:|||
Yeast   364 KKDLCEKIGQFAKEKIELADQLIIDNASTQIEESTTIVTYGSSKVLTELLLHNAISLKKNIKVIV 428

  Fly   465 VDSRPGCEGQELLRRLHATGIPCTYVLINAVGYVM-AEATKVLLGAHALLANGYVMARTGTAQVA 528
            |||||..||:::...|...|:...|.||.::..:. .:...|.||||::|:||::.:|.|||.:|
Yeast   429 VDSRPLFEGRKMAETLRNAGVNVMYALITSLDTIFNMDVDYVFLGAHSILSNGFLYSRAGTAMLA 493

  Fly   529 LVANAHNVPVLVCCETHKFSERFQTDAIVYNELSDPNQLV----------RGDKCQLSN------ 577
            :.|...|:|||||||:.|||:|.|.|::.:|||:|||.||          ||:|..|.|
Yeast   494 MSAKRRNIPVLVCCESLKFSQRVQLDSVTFNELADPNDLVNIDYENPVERRGNKGALLNQFIKER 558

  Fly   578 ---------------------------------------------WAAKGKLLPLNLSYDITPPE 597
                                                         |.....|..:|:.||:||||
Yeast   559 KFEKKKLAMENKPKGNKIGGKKGSEGESKDASNEEDSNSKNILDGWQELPSLNIVNILYDLTPPE 623

  Fly   598 LVSAVVTEVAILPCTSVPVILR 619
            .:..|:||...||.:|||||||
Yeast   624 YIKKVITEFGALPPSSVPVILR 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bdelta	NP_611790.1	GCD2	306..619	CDD:224105	120/375 (32%)
		IF-2B	323..611	CDD:279362	107/350 (31%)
GCD2	NP_011597.1	PHA03255	120..>232	CDD:165513	19/111 (17%)
		IF-2B	285..637	CDD:395798	107/351 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346307
Domainoid	1	1.000	173	1.000	Domainoid score	I753
eggNOG	1	0.900	-	-		E1_COG1184
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I845
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54388
OrthoFinder	1	1.000	-	-		FOG0003475
OrthoInspector	1	1.000	-	-		oto99865
orthoMCL	1	0.900	-	-		OOG6_101847
Panther	1	1.100	-	-	LDO	PTHR10233
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R373
SonicParanoid	1	1.000	-	-		X2839
TreeFam	1	0.960	-	-
	14	13.790