Protein Alignment eIF2Bdelta and eif2b4

DIOPT Version :10

• Sequence 1: NP_611790.1
• Gene: eIF2Bdelta / 37706
• FlyBaseID: FBgn0034858
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: XP_005160517.1
• Gene: eif2b4 / 541548
• ZFINID: ZDB-GENE-030131-955
• Length: 555
• Species: Danio rerio
• Alignment Length: 542
• Identity: 226/542 - (41%)
• Similarity: 315/542 - (58%)
• Gaps: 59/542 - (10%)

  Fly   128 KVQDAVASKTTQPAAVNGKDAEAGEKTREQIKAEREAKKAAKKAGKGGGAKVEGIAQQLADL--- 189
            |:||.|.:|:      .||:....||.|.: |.:::.||..|...||...|.:...::.|..
Zfish    21 KLQDIVKAKS------EGKELTKEEKQRLR-KEKKQHKKNKKDDNKGPPEKEKEKEKEKASAPPP 78

  Fly   190 ----------KVAEKAPVAASAAPSTTEADQEKKKPALSKAERRAIQEAQRAAKAQVQTKK--AQ 242
                      |.|..|||.|||:.:...|::..|..|..:|||||.|:::||:|   |.||  .|
Zfish    79 SKPVTQSPAHKAAAPAPVTASASETPAAAEKPAKTKAELRAERRARQDSERASK---QGKKEGGQ 140

  Fly   243 HAAKAPPSAAP--------------------------KGPNRKSVSPTTAATSSSPVKCPASTPN 281
            .:..:.|.|:|                          |...|:..|......:.:.|:.|..: :
Zfish   141 QSTSSKPKASPNELQPVVKRLPEHVQVDDPAALKKLAKKLERQQKSGQGCGLNITGVQVPLRS-D 204

  Fly   282 VDCRVKLFNHL---VCAKEDSQFINDP--LVHPSIARLGVQYAKRTVVGSNARCIAFLHALRQVV 341
            ...:|.||:||   ......:|.|:.|  ::||||.|||:||::..:.|||||.:|.|||.:||:
Zfish   205 YGYKVSLFSHLHQYSRKNPPTQQISIPATVIHPSIVRLGLQYSQGIIAGSNARSVALLHAFKQVI 269

  Fly   342 HDFETPAKKEFGRSLDAAVKHHVDHLHKCRPLAVSVSNAYKQFKNQLTQLPADVPETESKELLVH 406
            .|:.||..:|..|.|...:..::..|.:||||:.|:.||.|..|.:::.:|....|.|:|..|..
Zfish   270 QDYSTPPNEELSRDLVNKLSPYISFLSQCRPLSASMGNAIKYIKKEISNIPNQCKEEEAKGKLQA 334

  Fly   407 FIDTYIENQIGKAAQAISGFLQEKITDGDVLLTFACSSLIQFICEEAKRRQVAFRVIVVDSRPGC 471
            .||:||..:|..|::|||.:..|||::|||:|.:.||||:..|..||..:|..||||||||||..
Zfish   335 CIDSYINEKIILASEAISKYAIEKISNGDVILVYGCSSLVNHILCEAFEKQRQFRVIVVDSRPRL 399

  Fly   472 EGQELLRRLHATGIPCTYVLINAVGYVMAEATKVLLGAHALLANGYVMARTGTAQVALVANAHNV 536
            ||:|.||||...||.||||||:|:.|::.|.:||.|||||||||||||:|.||:|:||||.|:||
Zfish   400 EGREALRRLVKKGIRCTYVLISALSYILPEVSKVFLGAHALLANGYVMSRVGTSQIALVAKAYNV 464

  Fly   537 PVLVCCETHKFSERFQTDAIVYNELSDPNQLV--RGDKCQLSNWAAKGKLLPLNLSYDITPPELV 599
            ||||||||:||.||.|||:.|.|||.||:.|:  |..|..|.||.....|..|||.||:|||:.|
Zfish   465 PVLVCCETYKFCERVQTDSFVSNELDDPDDLIVTRNGKTHLENWQTVKSLGLLNLVYDVTPPDFV 529

  Fly   600 SAVVTEVAILPCTSVPVILRIK 621
            ..|:|::.::|||||||:||:|
Zfish   530 DLVITDLGMIPCTSVPVVLRVK 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bdelta	NP_611790.1	IF-2B	323..611	CDD:395798	149/289 (52%)
eif2b4	XP_005160517.1	IF-2B	251..541	CDD:395798	149/289 (52%)