DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Bdelta and tif224

DIOPT Version :9

Sequence 1:	NP_611790.1	Gene:	eIF2Bdelta / 37706	FlyBaseID:	FBgn0034858	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_594503.1	Gene:	tif224 / 2542064	PomBaseID:	SPAC21E11.06	Length:	467	Species:	Schizosaccharomyces pombe

Alignment Length:	474	Identity:	168/474 - (35%)
Similarity:	265/474 - (55%)	Gaps:	45/474 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 AKKAGKGGGAKVEGIAQQLADLKVAEKAPVAASA-----APSTTEADQEKKKPALSKAERRAIQE 227
            |||.||                   :::||:.|:     :|:|..:.....:|.||..|.:|:::
pombe     8 AKKDGK-------------------DQSPVSESSSVGGTSPATASSVVSPNEPKLSGKEAKALKK 53

  Fly   228 AQRAAKAQVQTKKAQHAAKAPPSAAPKG----PNRKSVSPTTAATSSSPVKCPASTPNV------ 282
            |::.|..:.:.:.|  ||..||..:.:.    ||:.| :....|:..:|...|.:..|:
pombe    54 ARKQASRRAKAEAA--AANNPPGVSEEKKVAIPNKNS-NQQKKASKQNPQNSPETDANLQEKKIF 115

  Fly   283 -DCRVKLFNHLVCAKEDSQFINDPLVHPSIARLGVQYAKRTVVGSNARCIAFLHALRQVVHDFET 346
             :.:|.:|:||...:..:.......:||::.|||::.|...:.|||.|||..|...:.|:.|::|
pombe   116 EEKQVSIFSHLDWRRRRTTENIPKDIHPAVIRLGLKLANYKIFGSNQRCIDLLKTFKIVIQDYQT 180

  Fly   347 PAKKEFGRSLDAAVKHHVDHLHKCRPLAVSVSNAYKQFKNQLTQLPADVPETESKELLVHFIDTY 411
            |......|.|...:...:.:|...|||::|:.||.:..|.:::.|..|:.:.|.||||:..||:|
pombe   181 PYGTTLSRHLTTHINSQIAYLVSTRPLSISMGNAIRFLKLEISVLDIDLTDDEGKELLLEKIDSY 245

  Fly   412 IENQIGKAAQAISGFLQEKITDGDVLLTFACSSLIQFICEEAKRRQVAFRVIVVDSRPGCEGQEL 476
            |.::|..|.|.|.....|||.||||:||:..||.:..:...||.....|||:||||||..||:..
pombe   246 IRDRIIIAGQVIVQAATEKIQDGDVILTYLHSSTVNDVLIHAKNVGKKFRVVVVDSRPEFEGRVC 310

  Fly   477 LRRLHATGIPCTYVLINAVGYVMAEATKVLLGAHALLANGYVMARTGTAQVALVANAHNVPVLVC 541
            |:.|...||.||||:|:|:.|:|.|.||:.||.||:|:||.:.:|.||:.::|:.:..||||:.|
pombe   311 LKLLTEHGIECTYVMISALSYIMQEVTKIFLGGHAMLSNGALYSRAGTSLISLLGHESNVPVIAC 375

  Fly   542 CETHKFSERFQTDAIVYNELSDPNQLVR--GDKCQ-----LSNWAAKGKLLPLNLSYDITPPELV 599
            ||::||:||.|.|::|||||:..:|||.  .|..:     |:||.:...|..|:|.||:|||.|:
pombe   376 CESYKFTERIQLDSLVYNELAPGDQLVNMGVDDFEEKPGVLANWKSVKNLKLLSLKYDVTPPRLI 440

  Fly   600 SAVVTEVAILPCTSVPVIL 618
            :..|.|:.:||.||||.|:
pombe   441 TVCVCEMGLLPSTSVPAII 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bdelta	NP_611790.1	GCD2	306..619	CDD:224105	135/320 (42%)
eIF2Bdelta	NP_611790.1	IF-2B	323..611	CDD:279362	123/294 (42%)
tif224	NP_594503.1	GCD2	140..464	CDD:224105	135/320 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	235	1.000	Domainoid score	I484
eggNOG	1	0.900	-	-		E1_COG1184
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I666
OMA	1	1.010	-	-		QHG54388
OrthoFinder	1	1.000	-	-		FOG0003475
OrthoInspector	1	1.000	-	-		oto101551
orthoMCL	1	0.900	-	-		OOG6_101847
Panther	1	1.100	-	-	LDO	PTHR10233
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R373
SonicParanoid	1	1.000	-	-		X2839
TreeFam	1	0.960	-	-
	13	12.860