DRSC/TRiP Functional Genomics Resources

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Protein Alignment eIF2Bdelta and tif224

DIOPT Version :10

Sequence 1:NP_611790.1 Gene:eIF2Bdelta / 37706 FlyBaseID:FBgn0034858 Length:626 Species:Drosophila melanogaster
Sequence 2:NP_594503.1 Gene:tif224 / 2542064 PomBaseID:SPAC21E11.06 Length:467 Species:Schizosaccharomyces pombe


Alignment Length:474 Identity:168/474 - (35%)
Similarity:265/474 - (55%) Gaps:45/474 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 AKKAGKGGGAKVEGIAQQLADLKVAEKAPVAASA-----APSTTEADQEKKKPALSKAERRAIQE 227
            |||.||                   :::||:.|:     :|:|..:.....:|.||..|.:|:::
pombe     8 AKKDGK-------------------DQSPVSESSSVGGTSPATASSVVSPNEPKLSGKEAKALKK 53

  Fly   228 AQRAAKAQVQTKKAQHAAKAPPSAAPKG----PNRKSVSPTTAATSSSPVKCPASTPNV------ 282
            |::.|..:.:.:.|  ||..||..:.:.    ||:.| :....|:..:|...|.:..|:      
pombe    54 ARKQASRRAKAEAA--AANNPPGVSEEKKVAIPNKNS-NQQKKASKQNPQNSPETDANLQEKKIF 115

  Fly   283 -DCRVKLFNHLVCAKEDSQFINDPLVHPSIARLGVQYAKRTVVGSNARCIAFLHALRQVVHDFET 346
             :.:|.:|:||...:..:.......:||::.|||::.|...:.|||.|||..|...:.|:.|::|
pombe   116 EEKQVSIFSHLDWRRRRTTENIPKDIHPAVIRLGLKLANYKIFGSNQRCIDLLKTFKIVIQDYQT 180

  Fly   347 PAKKEFGRSLDAAVKHHVDHLHKCRPLAVSVSNAYKQFKNQLTQLPADVPETESKELLVHFIDTY 411
            |......|.|...:...:.:|...|||::|:.||.:..|.:::.|..|:.:.|.||||:..||:|
pombe   181 PYGTTLSRHLTTHINSQIAYLVSTRPLSISMGNAIRFLKLEISVLDIDLTDDEGKELLLEKIDSY 245

  Fly   412 IENQIGKAAQAISGFLQEKITDGDVLLTFACSSLIQFICEEAKRRQVAFRVIVVDSRPGCEGQEL 476
            |.::|..|.|.|.....|||.||||:||:..||.:..:...||.....|||:||||||..||:..
pombe   246 IRDRIIIAGQVIVQAATEKIQDGDVILTYLHSSTVNDVLIHAKNVGKKFRVVVVDSRPEFEGRVC 310

  Fly   477 LRRLHATGIPCTYVLINAVGYVMAEATKVLLGAHALLANGYVMARTGTAQVALVANAHNVPVLVC 541
            |:.|...||.||||:|:|:.|:|.|.||:.||.||:|:||.:.:|.||:.::|:.:..||||:.|
pombe   311 LKLLTEHGIECTYVMISALSYIMQEVTKIFLGGHAMLSNGALYSRAGTSLISLLGHESNVPVIAC 375

  Fly   542 CETHKFSERFQTDAIVYNELSDPNQLVR--GDKCQ-----LSNWAAKGKLLPLNLSYDITPPELV 599
            ||::||:||.|.|::|||||:..:|||.  .|..:     |:||.:...|..|:|.||:|||.|:
pombe   376 CESYKFTERIQLDSLVYNELAPGDQLVNMGVDDFEEKPGVLANWKSVKNLKLLSLKYDVTPPRLI 440

  Fly   600 SAVVTEVAILPCTSVPVIL 618
            :..|.|:.:||.||||.|:
pombe   441 TVCVCEMGLLPSTSVPAII 459

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eIF2BdeltaNP_611790.1 IF-2B 323..611 CDD:395798 123/294 (42%)
tif224NP_594503.1 IF-2B 156..451 CDD:395798 122/294 (41%)

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