Protein Alignment eIF2Bdelta and EIF2B1

DIOPT Version :9

• Sequence 1: NP_611790.1
• Gene: eIF2Bdelta / 37706
• FlyBaseID: FBgn0034858
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_001405.1
• Gene: EIF2B1 / 1967
• HGNCID: 3257
• Length: 305
• Species: Homo sapiens
• Alignment Length: 325
• Identity: 82/325 - (25%)
• Similarity: 142/325 - (43%)
• Gaps: 49/325 - (15%)

  Fly   299 SQFINDPLVHPSIA--RLGVQYAKR----TVVGSNARCIAFLHALRQVVHDFETPAKKE-FGRSL 356
            ||...||.:..::|  |..:::.||    |:.|..|...:.:..|..|.......:..| |.|.:
Human    12 SQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFI 76

  Fly   357 DAAVKHHVDHLHKCRPLAVSVSNAYKQFKNQLTQLPADVPETESKELLVHFIDTYIENQIGKAAQ 421
            ..|...:.|: .||:.:.:                       |..||.:        .:|..:..
Human    77 SLASLEYSDY-SKCKKIMI-----------------------ERGELFL--------RRISLSRN 109

  Fly   422 AISGFLQEKITDGDVLLTFACSSLIQFICEEAKRRQVAFRVIVVDSRPGCEGQELLRRLHATGIP 486
            .|:......|.||..:||.|.|.::..:.|.|...:..|.|.|.:|:|...|:::.:.|....:|
Human   110 KIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVP 174

  Fly   487 CTYVLINAVGYVMAEATKVLLGAHALLANGYVMARTGTAQVALVANAHNVPVLVCCETHKFSERF 551
            .|.||..||||:|.:|..|::||..::.||.::.:.||.|:|:.|.|.|.|..|..|:.||...|
Human   175 VTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLF 239

  Fly   552 QTDAIVYNELSDPNQL-VRGDKCQLSNWAAKGKLLPLNLSY-DITPPELVSAVVTEVAILPCTSV 614
            .     .|:...|::. .:.|..::   |..|:.|.....: |.|.|.|::.:.|::.:|..::|
Human   240 P-----LNQQDVPDKFKYKADTLKV---AQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAV 296

  Fly   615  614
            Human   297  296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bdelta	NP_611790.1	GCD2	306..619	CDD:224105	78/318 (25%)
		IF-2B	323..611	CDD:279362	72/290 (25%)
EIF2B1	NP_001405.1	IF-2B	15..293	CDD:395798	79/317 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810