DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Bdelta and eif-2Bdelta

DIOPT Version :9

Sequence 1:	NP_611790.1	Gene:	eIF2Bdelta / 37706	FlyBaseID:	FBgn0034858	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_001023784.1	Gene:	eif-2Bdelta / 179331	WormBaseID:	WBGene00008670	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	139/565 - (24%)
Similarity:	226/565 - (40%)	Gaps:	91/565 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 TTPSAPATKIITEVEQTTITTKL---TTTTTTKVQDAVASKTTQPAAVNGKDAEAGEK--TREQI 158
            |....||.|:....|:.....||   .....::....|...||......|:|.....|  |.|..
Worm     8 TDKKHPADKLKETFEKLNNEVKLLGMILGVKSENNQQVVPPTTAEEPAQGEDKNQYHKDVTAEDK 72

  Fly   159 KAEREAKKAAKKAGKGGGAKVEGIAQQLADLKVAEKAPVAASAAPSTTEADQEKKKP------AL 217
            ||.:.||.|.|||              .|:..||.|   ||:||.||....|:|:||      ..
Worm    73 KARKAAKAAEKKA--------------RAEKSVANK---AAAAAGSTQNQGQKKEKPPKEHSAVP 120

  Fly   218 SKAERRAIQE--------AQRAAKAQ---VQTKKAQHAAKAPPSAAPKGPNRKSV---------S 262
            |::..:.|:|        .|.|||.:   ::..|...:.|  |:........|:|         |
Worm   121 SESTTKLIEENAQLTKTTEQLAAKMETLVIEDVKINGSLK--PAIKKSTGVEKNVRHVHNVIMPS 183

  Fly   263 PTTAATSSSPVKCPASTPNVDCRV--KLFNHLVCAKED-SQFINDPLVHPSIARLGVQYAKRTVV 324
            ..|.....:..|...|..:.|..|  ::.:..:...:| :.|::   :||:...|..:.....:.
Worm   184 VVTFDLPKNQTKTLPSASDSDEAVASEIESTAIAQLDDATSFVH---IHPAFLTLMAKAELEKIP 245

  Fly   325 GSNARCIAFLHALRQVVHDFETPAKKE------FGRSLDAAVKHHVDHLHKCR--PLAVSVSNAY 381
            .....||.|:.|.::.:.|:....:|.      ||..||.|::..:.|:.:..  ||..::.|..
Worm   246 DVETVCIQFIAAFKEFLRDWTVEREKNNINASTFGHDLDLAIRPQLAHMTQNGHWPLPFALGNTV 310

  Fly   382 KQFKNQLTQLPADVPETESKELLVHFIDTYIENQIGKAAQAISGFLQEKITDGDVLLTFACSSLI 446
            :..|..:.:|.........:||.|:..||...| ...|.:|||..|..||.....::.|....::
Worm   311 RLLKRTIKRLEESTNMKCEEELQVYLEDTLAIN-FCHAYKAISQLLVRKIQQFKKVVVFDWCPVV 374

  Fly   447 QFICEEAKRRQVAFRVIVVDSRPGCEGQELLRRLHATGIPCTYVLINAVGYVMAEATKVLLGAHA 511
            ..:..|||::....::.|:|:.....|...::.....|....||.:....:....:..::||..|
Worm   375 NHVLLEAKQQIPDMQLSVIDANSNGRGTRHVKSFVDQGYNVKYVTMKGASWASLASGVLILGCSA 439

  Fly   512 LLANGYVMARTGTAQVALVANAHNVPVLVCCETHKFSERFQTDAIVYNELSDPNQLVRGDKCQLS 576
            :.|||.|.||.|...|.|.||.:|:||:|..|..||.::.|    ||..:
Worm   440 IFANGAVAARKGALAVVLCANHYNIPVIVVAEHFKFIDKGQ----VYQRV--------------- 485

  Fly   577 NWAAKGKLLPLNLSYDITPPELVSAVVTEVAILPCTSVPVILRIK 621
              |..|:     .:.:....:||:||||::.||..||.|.:|:.|
Worm   486 --ALLGR-----QNIECIQSDLVTAVVTDLRILGPTSAPAVLKAK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bdelta	NP_611790.1	GCD2	306..619	CDD:224105	80/320 (25%)
eIF2Bdelta	NP_611790.1	IF-2B	323..611	CDD:279362	74/295 (25%)
eif-2Bdelta	NP_001023784.1	GCD2	227..521	CDD:275543	80/323 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166871
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	106	1.000	Inparanoid score	I3506
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54388
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003475
OrthoInspector	1	1.000	-	-		oto18569
orthoMCL	1	0.900	-	-		OOG6_101847
Panther	1	1.100	-	-	LDO	PTHR10233
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R373
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.930