Protein Alignment eIF2Bdelta and Eif2b4

DIOPT Version :10

• Sequence 1: NP_611790.1
• Gene: eIF2Bdelta / 37706
• FlyBaseID: FBgn0034858
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: XP_038967625.1
• Gene: Eif2b4 / 117019
• RGDID: 620208
• Length: 544
• Species: Rattus norvegicus
• Alignment Length: 572
• Identity: 230/572 - (40%)
• Similarity: 321/572 - (56%)
• Gaps: 88/572 - (15%)

  Fly   101 PSAPATKIITEVEQTTITTKLTTTTTTKVQDAVASKTTQPAAVNGKDAEAG-EKTRE---QIKAE 161
            |:||     |.:.::  :..|:.:......|| .|::.....::.:...|| |.|:|   |::.|
  Rat     6 PAAP-----TNLPKS--SRSLSGSLCALFSDA-ESRSEMKTELSPRPGAAGRELTQEEKLQLRKE 62

  Fly   162 REAKKAAKKAGKG-----GGA-----------KVEGIAQQLADLKVAEKAPVAASAAPSTTEADQ 210
            ::.:|..:|..||     |.|           :::|...||.. ...||.|...|.|.
  Rat    63 KKQQKKKRKEEKGADQEIGSAVSAAQRQDPVRELQGTGSQLGG-TTGEKLPAGRSKAE------- 119

  Fly   211 EKKKPALSKAERRAIQEAQRAAKAQVQTKKAQHAAKAPPSAAPKGPNRKSVSPTTAATSSSPVK- 274
                   .:|||||.|||:||.|   |.:|.:....:|.:.           |:||..::|.||
  Rat   120 -------LRAERRAKQEAERALK---QARKGEQGGPSPQAC-----------PSTAGEATSGVKR 163

  Fly   275 CPASTPNVD-----------------------CRVKLFNHLVCAKEDS---QFINDP--LVHPSI 311
            .|..|...|                       .:|.||:||......|   |:::.|  ::||::
  Rat   164 VPEHTQADDPTLLRRLLRKPDRQQVPTRKDYGSKVSLFSHLPQYSRQSSLTQYMSIPSSVIHPAM 228

  Fly   312 ARLGVQYAKRTVVGSNARCIAFLHALRQVVHDFETPAKKEFGRSLDAAVKHHVDHLHKCRPLAVS 376
            .|||:||::..|.||||||||.||||:||:.|:.||..:|..|.|...:|.::..|.:|||::.|
  Rat   229 VRLGLQYSQGLVSGSNARCIALLHALQQVIQDYTTPPNEELSRDLVNKLKPYISFLTQCRPMSAS 293

  Fly   377 VSNAYKQFKNQLTQLPADVPETESKELLVHFIDTYIENQIGKAAQAISGFLQEKITDGDVLLTFA 441
            :.||.|.|..::|.:.:...|.|:|..|...||.|::.:|..|:||||.|..:||:||||:|.:.
  Rat   294 MCNAIKFFNKEVTGMSSSKREEEAKSELKEAIDRYVQEKIVLASQAISRFASKKISDGDVILVYG 358

  Fly   442 CSSLIQFICEEAKRRQVAFRVIVVDSRPGCEGQELLRRLHATGIPCTYVLINAVGYVMAEATKVL 506
            ||||:..|.:||......|||:||||||..||:.:|..|...|:|.:|:||.|..||:.|.:|||
  Rat   359 CSSLVSRILQEAWVEGRRFRVVVVDSRPRLEGRHMLHCLVRAGVPTSYLLIPAASYVLPEVSKVL 423

  Fly   507 LGAHALLANGYVMARTGTAQVALVANAHNVPVLVCCETHKFSERFQTDAIVYNELSDPN--QLVR 569
            ||||||||||.||:|.||||:||||.||||||||||||:||.||.||||.|.|||.||:  |..|
  Rat   424 LGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKR 488

  Fly   570 GDKCQLSNWAAKGKLLPLNLSYDITPPELVSAVVTEVAILPCTSVPVILRIK 621
            ||:..|:||.....|..|||.||:||||||..|:||:.::||:||||:||:|
  Rat   489 GDQVTLANWQNNSSLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVK 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Bdelta	NP_611790.1	IF-2B	323..611	CDD:395798	154/289 (53%)
Eif2b4	XP_038967625.1	IF-2B	240..530	CDD:395798	154/289 (53%)