DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30414 and HGF

DIOPT Version :9

Sequence 1:	NP_001163264.1	Gene:	CG30414 / 37705	FlyBaseID:	FBgn0050414	Length:	305	Species:	Drosophila melanogaster
Sequence 2:	NP_000592.3	Gene:	HGF / 3082	HGNCID:	4893	Length:	728	Species:	Homo sapiens

Alignment Length:	289	Identity:	73/289 - (25%)
Similarity:	109/289 - (37%)	Gaps:	85/289 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SCGTTKPEFIPMITG---GADAGLFSNPWMV--KVLGEKLCGGSLITSRFVLTAAHCIVSTHMRV 88
            ||..||.  :.::.|   ..:.|     |||  :...:.:||||||...:||||..|
Human   486 SCAKTKQ--LRVVNGIPTRTNIG-----WMVSLRYRNKHICGGSLIKESWVLTARQC-------- 535

  Fly    89 RLGEYKTRFPGKDCSRCVPKSYKLRRIRLGEYDTRFPGKDCCVPKSYELAVDRKILHADYNLNLD 153
                    ||.:|.     |.|:   ..||.:|....|.:.|   ...|.|.:.:...:     .
Human   536 --------FPSRDL-----KDYE---AWLGIHDVHGRGDEKC---KQVLNVSQLVYGPE-----G 576

  Fly   154 NDIGLLRMKSFVQYSDYVRPICLLVEG-HMAESPIFNITGWGVTN----DGTPSRRLQRATVYNT 213
            :|:.|:::.......|:|..|.|...| .:.|....::.|||.|.    ||.    |:.|.:|..
Human   577 SDLVLMKLARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGL----LRVAHLYIM 637

  Fly   214 DLHFC----RSKFTKQVDESQICAAG--TNSDACHGDSGGPLSAQ-----------VPFAGSWLT 261
            ....|    |.|.|  ::||:|||..  ..|..|.||.||||..:           ||..|..:.
Human   638 GNEKCSQHHRGKVT--LNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIP 700

  Fly   262 FQYGLVSYGSAACHSFSVYTNVTHHRDWI 290
            .:.|             ::..|.::..||
Human   701 NRPG-------------IFVRVAYYAKWI 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30414	NP_001163264.1	Tryp_SPc	41..290	CDD:214473	67/275 (24%)
CG30414	NP_001163264.1	Tryp_SPc	41..290	CDD:238113	67/275 (24%)
HGF	NP_000592.3	PAN_APPLE	39..122	CDD:238074
		KR	126..208	CDD:214527
		KR	210..290	CDD:214527
		KR	304..384	CDD:214527
		KR	388..470	CDD:238056
		Tryp_SPc	494..716	CDD:214473	67/277 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143004
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930