DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Golgin245 and golgb1

DIOPT Version :9

Sequence 1:	NP_611787.2	Gene:	Golgin245 / 37702	FlyBaseID:	FBgn0034854	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	XP_005164965.1	Gene:	golgb1 / 566353	ZFINID:	ZDB-GENE-030429-9	Length:	3356	Species:	Danio rerio

Alignment Length:	1725	Identity:	392/1725 - (22%)
Similarity:	716/1725 - (41%)	Gaps:	439/1725 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKNKLIE-----EVKASPSKFQQFANAAQAAVSSSSSTTPNSETNTSNNENFFSITEEDTPQNSP 64
            |.|:::|     |.|.:..|. :..||..|     .......|||....|::......:|||..
Zfish  1614 LLNRIMELEGLLESKNTADKV-EIVNAGPA-----RQNLEKPETNDWGQEDWVDFAMTETPQEQ- 1671

  Fly    65 YRIQKLPATSASALRGRSTQSLNGATSRTRKLSNSSMASDVSFRLPTYEAPAVYHLQSDLDETSS 129
               .:.|..       ::::.:..|.....|...::.| |:..||        :..||....|.|
Zfish  1672 ---SQQPMV-------KNSEDIINALQEELKFEQAAHA-DLKVRL--------HESQSSQSLTDS 1717

  Fly   130 EFDDSASTARLDVITKDQLYDAYKKSLDRYHKYRCRYTDLAKKYKELERDSSKARSVLVETQDKA 194
            :|                             |..|         :|||....|.|.:...||:
Zfish  1718 KF-----------------------------KELC---------EELEAMKEKERHIDALTQE-- 1742

  Fly   195 LRRISELREQCTLEQQAKAHLEEALRVEMDDMSCKMQAYQTKLQLL--GENP-ENITAALERSGQ 256
               |..|||:|   |:|:||.|: |:|::|      :|::...:.:  .|:| :.:.:.:|...|
Zfish  1743 ---IETLREKC---QRAEAHAEK-LKVDVD------EAWEAAKRSISDAESPIKALQSEVEEFKQ 1794

  Fly   257 QL--ESEQLIDLEESIGKSPLSTNGSSGVSDLQRLLKERDEQLKSVTEKYEAVRKQEEENVLLLA 319
            .|  ::::::||.:.:.:.      |..:..:|..::|:|:|:.|:
Zfish  1795 FLKCKNDEIVDLSQQLSEQ------SCLLLKMQETVQEKDQQIVSL------------------- 1834

  Fly   320 QTKQAIHTELELKDTEVRKLQEKLKQLESQRESHNNEVKEQFKKLQATKQEVDAKLMATEHLLNT 384
              :|.:..|           |:|:::||::......|.|:...|||..::::.|.|::.:   ..
Zfish  1835 --QQGLKAE-----------QDKVQKLEAELPQREEEEKDNGVKLQQLQRKLQAALVSRK---EA 1883

  Fly   385 LKESYAIKEQQVVTLEAQLEAIRVENEQKVK----DLQKQNEDRNTQASDSSEQLKKLQAAVQDA 445
            |||..|:||:|     |..|.|::|..||::    :|.|..|:|.....:....|.:.|:.....
Zfish  1884 LKEKQALKEEQ-----AAAEKIKLELHQKLELIEMELNKSREEREKLIEEVDRTLLENQSLSASC 1943

  Fly   446 ESQLLSKDQLLES----LRSEQAAK---EQQLKHLKEQLGKLKQENENYLDKLRENKKSSDSQTN 503
            ||..|:.:.:|..    .|....||   ||..|.|:|::..:|:|.|:.|       ||.::.::
Zfish  1944 ESLKLAMEGVLNEKDACKRQADIAKEESEQVCKQLEEKVQNMKEEYESLL-------KSYENVSD 2001

  Fly   504 EAQDQQKKLQAAKDEAESKLLATEELLH-SLRNDYK--AQE--EKVALLEDKLKTLSKENDVNVE 563
            ||:..:|.|:||:.|.:.  |||:...| :.|.:.:  |:|  ::|.:::||::..:|   |..:
Zfish  2002 EAERVRKVLEAARQERQE--LATKARAHEAARQEAERLAEEAMKEVDVVKDKMRKFAK---VKHQ 2061

  Fly   564 KLHHINEQREAQSTDSQQKI---------NELRAAKDEAEAKLLSTEHSLNALQAALSAK---EE 616
            |:..:.|:.|......::|:         .||...|.|.|  :|...::: ||....|.:   ||
Zfish  2062 KIMDLEEENERLREQEEKKLTKHTETDVKQELERIKQEFE--ILKANYNI-ALDDKKSLELEAEE 2123

  Fly   617 QAASLE----QSLNALKTESEHSLQDLRLHNDQ----LLEIVQRHQQNDW-EAQLARARE----- 667
            ....||    :.:....|.|..:::::::...|    |:||.:...::.: ||.|.:..|
Zfish  2124 LRLRLEKIQSKGVETFDTCSVETIKEVKVITQQNSPNLIEIQEYQCESIFPEANLTKPLESINTE 2188

  Fly   668 ---ELAAIQ------SQRELHALELEKSLE----------------MERESVAALNSEKASQEEQ 707
               |:..:|      :|.|....|||.|||                ||..:...|::|..|.::|
Zfish  2189 PDQEVTEVQTKIEIATQTEERLKELETSLETAENKIKELEIALEHHMEFRNEQILDAELTSIKQQ 2253

  Fly   708 HRLKLEQLQREIQILQDQHANSESETVAALKGQLEALSQDLATSQASLLAKEKELKASGNKLNKI 772
            .:   |.|:||     |.|    .|.::..:.||:.|..:|...:..|   |:.|.   |:|.::
Zfish  2254 LQ---ESLERE-----DIH----KEEISKKENQLQELRMNLEAERDDL---EERLM---NQLAQL 2300

  Fly   773 KKQHEQHQAKSSDQSARLEALQSELADRLSHSRQVESEKEELQARVTGILEEIGTMQAQMQQVQD 837
            ......:|.::||...||..:|.||       .::|.|:.||:|.|....:....|:..|:|...
Zfish  2301 NGSIAGYQQEASDSRDRLTDMQREL-------EKLERERAELEAEVLSERDRAARMEEDMRQAHR 2358

  Fly   838 SHSELERE---KRKLESRIESLQQEQVDSSAQDERTSAKLEEIQSENTKLAERNCL-LEEQTNHL 898
            ..:|.|.|   :|:||.:::|.|:.:..|..:..:....|.|.|.|..:| :::|: .:|:.:.|
Zfish  2359 ERAEAEAETGKQRELEQKLKSAQRFKEGSQNRTRQLEELLREKQLEVRQL-QKDCIGYQERISEL 2422

  Fly   899 --------------ESQLQAKQDEIGKIQAKLQQVLDEHSKLQNAQELMDHDHRTLQDKCDAYEK 949
                          .::|:|.:.||..|......:..|.|..:...::...:.|  |.:.|....
Zfish  2423 AKEVKSLLLVRDEVRAELEAARLEIANILQDKAFIASELSTYKGKLDMALEEAR--QAQADKLSA 2485

  Fly   950 DKLLTKHTLDCLQSASEELHRVKANLDRELKEQDQQLSE-LRERQREQEQQLK-----DQAERCA 1008
            ::.:.:...:....|...|..|:..|..|||:.:.:|.: .|:|:||:|..|:     :.|:|.|
Zfish  2486 EQFIQRKEAELKADAERTLDEVRYRLGAELKQIELRLEKSYRDREREEEATLEARNIAEAADRHA 2550

  Fly  1009 K-LKAQNSESETQLQA---TISNLREQ----LDAYKQTEQGIQEKLQATNSSYTTQIATLEARWS 1065
            : ::|:..|:..:|.|   ::|:|::.    ||..||.|.....:||...:    .:...|||..
Zfish  2551 QDMQARLDEALARLAAFSRSMSSLQDDRDRVLDEAKQWENRFHSELQEKEA----DVREAEARAK 2611

  Fly  1066 AANSD--------------VERLHEANDALQLEMEQLKIKHGQ-------EREE-------VKES 1102
            ..:..              :||..:|.:.||||:..::.||.:       |||:       |:.:
Zfish  2612 ELSEQLQREMTQKVELQNLLERTQKAEENLQLELSSVEKKHNESLAVLEKEREDLQQKLTLVEAN 2676

  Fly  1103 IAQKNRQVVELQ---EAMATRDRQLQEKI-----EASEKLAKFDEILIENEYLNKHTKQLEAELA 1159
            ::|...|:..|:   |.:..|.:.|.|.:     :|.|..|...|...|...|....:|||.:|.
Zfish  2677 LSQALSQLASLETEAEGLRHRTKALDEAVDQLQSDAVEARAVIKERETEERRLCLMVEQLETDLG 2741

  Fly  1160 ESAELKEKL-------KSLQCELYVLQEKAEQHAVQMAEKETQSATATAEVSELKKAIEE----- 1212
            ....|.|.|       :..:.||...:|:|...||:.|.|:.......|| :||:|..||
Zfish  2742 SLKNLTETLQVALGEKEKREVELLGEKEQAVTQAVEEARKDADGRAEMAE-NELEKRREELRGLE 2805

  Fly  1213 ----QAVELTRQK--EHASFVTEQSDAVQKD---LLQAQQQLHDKQIELAMSRD----------- 1257
                :|.|:|.|.  :..|| |:...::|.|   :|...:||.:|.:::.|.:|
Zfish  2806 ERLRKAEEVTFQSRAQLESF-TKAMGSLQDDRDRVLSQYKQLEEKHLQVMMEKDSLIQEAAGENN 2869

  Fly  1258 ------------------EQALLQAEADGLR---QEVICLKEHLSPSTDSDSLRSLNER---LQR 1298
                              |.|.|.|:..|.|   .:|:.:|:    |.....|.:..||   |:|
Zfish  2870 RLKEELRALLSQRDDLNAENAKLAAQLHGYRNDLNQVLTMKD----SQHKQILAAQVERISFLER 2930

  Fly  1299 ELEDLKHKSAGAESNMQQ---------------------------EIEELQANNQQMAERINELE 1336
            |.|||.:.....|.::.|                           |:|:|:...|...:||..||
Zfish  2931 EREDLVNHIQAFEKDIAQGRAPLLEQEYLSQASEGSVDKQDAPGAEVEKLREQLQAARKRITNLE 2995

  Fly  1337 TLRAGIQAQQLLASMAPKNVQEAAAAGEKAELESKLKEIMNEVQDVTNRNLFLEQKCENFLILEQ 1401
            .:   ::.::...::..|.::|....|.....|::..|  ..|.::....|.:||:     :||:
Zfish  2996 EI---LELEKETQAVHSKELKELRWEGGVLRTEAETAE--ERVAELARDLLMMEQQ-----LLEE 3050

  Fly  1402 SN--ERLKLQNAKLSRQLDETLVSMQHSEAVPANTEFEYLRNIMFQYL--TGNTNNE-------- 1454
            ..  .:|::||    :...:.:.|:|.:.....| |.:.|| :.|..:  ||:..:.
Zfish  3051 REAVSQLRVQN----QSFGQAMASLQDARDQAVN-EAKELR-LRFDDINRTGHAVSSPSDPKGEV 3109

  Fly  1455 -TLVKVISAVLKFSPQQAQVALEKEHQRRSLLNKL 1488
             :|...:||:    ....:..||:...:||.|::|
Zfish  3110 WSLKNALSAL----QNDRERMLEQMQVQRSELDRL 3140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Golgin245	NP_611787.2	Smc	286..1089	CDD:224117	217/915 (24%)
		Phage_GPO	<306..421	CDD:301727	28/118 (24%)
		Smc	737..1442	CDD:224117	197/857 (23%)
		MIT_CorA-like	<1244..>1333	CDD:294313	30/150 (20%)
		Grip	1433..1477	CDD:197860	11/54 (20%)
golgb1	XP_005164965.1	SMC_prok_B	139..>826	CDD:274008
		SMC_prok_B	643..1409	CDD:274008
		SMC_prok_B	1229..2039	CDD:274008	126/558 (23%)
		ETAA1	<1795..1881	CDD:291995	22/123 (18%)
		SMC_prok_B	2371..3147	CDD:274008	180/803 (22%)
		DUF3418	<2432..2566	CDD:288730	30/135 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000