Protein Alignment Golgin245 and Golga4

DIOPT Version :9

• Sequence 1: NP_611787.2
• Gene: Golgin245 / 37702
• FlyBaseID: FBgn0034854
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: XP_036010996.1
• Gene: Golga4 / 54214
• MGIID: 1859646
• Length: 2280
• Species: Mus musculus
• Alignment Length: 2310
• Identity: 489/2310 - (21%)
• Similarity: 845/2310 - (36%)
• Gaps: 870/2310 - (37%)

  Fly     1 MFANLKNKLIEEVKASPSKFQQFANAAQAAVSSSSSTTPNSETNTSNNENFFSITEEDTPQN--- 62
            ||..||.|:.||.       ||...|...|.:||||:||   |.|.:..:.|:...:|...|
Mouse     1 MFKKLKQKISEEQ-------QQLQQALAPAQASSSSSTP---TRTRSRTSSFTDQLDDVTPNREL 55

  Fly    63 -----------SPYRI-----QKLPATSASALRG--RSTQSLNGATSRTRKLSNS----SMASDV 105
                       |.|.|     .|.|.|...::..  ::|:|.:|.:......|.|    :.|..:
Mouse    56 LAGMVAEPAFLSEYTIFALDSSKQPKTQTGSVNASTQATKSPDGVSKDESSPSQSGDTQTFAQKL 120

  Fly   106 SFRLPTYE----APAVYHL------------------QSDLDETSSEFD---DSASTA-----RL 140
            ..|:|:.|    :|....|                  |.|||.:::.||   |..|.|     ..
Mouse   121 QLRVPSMESLFRSPIKESLFRSSKEPLVRTSSRESLNQLDLDCSAAAFDPPSDMESEAEDAPWNS 185

  Fly   141 DVITKDQLYDAYKKSLDRYHKYRCRYTDLAKKYKELERDSSKARSVLVETQDKALRRISELREQC 205
            |.::::||....::.......||.:|::|...::.|:|:..|.:.:|.::|||:|||||||||:.
Mouse   186 DGLSREQLLQRLRRMERSLSSYRGKYSELVTAFQTLQREKKKLQGILSQSQDKSLRRISELREEL 250

  Fly   206 TLEQQAKAHLEEALRVEMDDMSCKMQAYQTKLQLLGE----NPENITAALERSGQQLESE----- 261
            .::||||.||::.....:::....:...||::.||.:    .|.|:.|.......:|::|
Mouse   251 QMDQQAKKHLQDEFDACLEEKDQYISVLQTQVSLLKQRLQNGPMNVDAPKPLPPGELQAEVHGDT 315

  Fly   262 -----------------------QLIDLEESIGKSPLSTNGS---------SGVSDLQRLLKERD 294
                                   |.:..:|::.:....|.||         |....||..|.||.
Mouse   316 EKMEGVGEPVGGGTSAKTLEMLQQRVKRQENLLQRCKETIGSHKEQCALLLSEKEALQEQLDERL 380

  Fly   295 EQLKSVTEKYEA---------------VRKQEEENVLLLAQTKQAIHTELELKDTEVRKLQEKLK 344
            ::|:.:.|.:.|               :.:.|::..:::.:||:.:...||||:.|:.:|:..:|
Mouse   381 QELEKMKELHMAEKTKLITQLRDAKNLIEQLEQDKGMVITETKRQMLETLELKEDEIAQLRSHIK 445

  Fly   345 QLESQRESHNNEVKEQFKKLQ-ATKQEVDAKLMATEHLLNTLKESYAIKEQQVVTLEAQLEAI-R 407
            |:.:|.|    |::||.:|.: |...|.|......|..|:|.:::...:.:..:.::.|::|: |
Mouse   446 QMTTQGE----ELREQKEKSERAALYEQDWAFEELEKALSTAQKTEDAQRRMKMEMDEQMKAVER 506

  Fly   408 VENEQKVK---DLQKQNEDRNTQASDSSEQ----LKKLQAAVQDAESQLLSK----------DQL 455
            ...|::::   :|.:..::..:.|..:||:    |:||.|....::.|.||:          :|:
Mouse   507 ASEEERLRLQHELSRVRQEAASMAKKNSEEQVAALQKLHAEELASKEQELSRRLEARERELQEQM 571

  Fly   456 ---LESLRSE----QAAKEQQ---------------LKHLKEQLGKLKQENENYLDKLRENKKSS 498
               ||..|||    ...||||               |...:.:|.:|.||.|.|..::.|.:.|.
Mouse   572 RIALEKSRSEYLKLTQEKEQQESLALEELELQKKAILTESENKLQELGQEAEAYRTRILELETSL 636

  Fly   499 DSQTNEAQDQQK----KLQAAKDEAESKLLA------TE-------------ELLHSLRNDYKA- 539
            :....|::.|.:    .|:|.|::...:|.|      ||             |.|.||...::|
Mouse   637 EKSLQESKTQSEHLAVHLEAEKNKHNKELTALAEQHRTEVEGLQQQQDSLWTERLQSLSQQHQAA 701

  Fly   540 --------QEEKVALLEDK------------LKTLSK---------------------------- 556
                    |:||.|||::|            .|||.|
Mouse   702 VEELREKYQQEKDALLKEKESLFQAHIQDMNEKTLEKLDKKQMELESVSSELSEALRARDQLAEE 766

  Fly   557 ---------------ENDVNVEKLHHINEQREAQSTDSQQKINELRAAK-------------DEA 593
                           |.::..::.||   |||..|...||::...||.|             ||.
Mouse   767 LSVLRGDADKMKQALEAELEEQRRHH---QREVGSISEQQELTVRRAEKALKDELSRLGALLDER 828

  Fly   594 EAKLLSTEHSLNALQAALSAKEEQAASLEQSLNALKTESEHSLQDLRLHNDQLLEIVQRHQQNDW 658
            :..|...:..:..|:|.|   ::.|..|:|:|..|         || ||::|   ...|.|...:
Mouse   829 DEHLRERQARVQDLEAHL---QKSAGELQQALAKL---------DL-LHSEQ---SAAREQAGAY 877

  Fly   659 EAQLARAREELAAIQSQREL---HALELE-------KSLEMERESVAALNSEKASQEEQHRLKLE 713
            |.|||:.::::..:::::.|   ..:|:|       :.|:.:|..|..|..:::..||:.| .|.
Mouse   878 EEQLAQMQQKVLDLETEKSLLTKQVVEMETHKKHVCEELDAQRAQVQQLERQRSELEEKVR-SLA 941

  Fly   714 QLQ---------------------------------REIQILQDQHANSESETVAALKGQLEALS 745
            |||                                 :||:||: |..:|:.|:::.|..:.|...
Mouse   942 QLQDSQLKNSTVEKEQARQSLMEKENIILQMREEQAKEIEILK-QTLSSKEESISILHEEYETKF 1005

  Fly   746 QDLATSQASLLAKEKELKASGNKL----NKIKKQ-------------------HEQHQAKS---S 784
            ::.......:..|.||::.:..||    .|:||:                   .|..||.|   |
Mouse  1006 KNQEKRMEKIKQKAKEMQETKKKLLDQEAKLKKELENTVLELSQKEKQFNAQILEMAQANSAGIS 1070

  Fly   785 DQSARLEALQ------------------------------SELADR-----------LSHSRQ-- 806
            |..:|||..|                              :||.|:           |...||
Mouse  1071 DTVSRLEENQRQQIESLTGAHQRKLDDVIEAWEKKLSQQAAELRDKHAEQMEEKEQGLGELRQKV 1135

  Fly   807 --VESEKEELQARVTGILEEI-------GTMQAQMQQ-------VQDSHSELEREKRKLESRIE- 854
              |:||||||...|..:.|.:       ..:|.|::|       :.:..|:|:.:..|||:.:.
Mouse  1136 RIVQSEKEELTKEVARLKEAVSGQDVALAGLQGQLEQKSAVIVSLSERESQLQSQVEKLEADLGC 1200

  Fly   855 ------SLQQEQVD-------------------SSAQDERTSAK--------------------L 874
                  |||:|..:                   .:|:.|..|.|                    |
Mouse  1201 SLSEKLSLQEELAELKLLADKSQLRVSELTGQVQAAEKELQSCKSLHELSKKSLEDKSLNLKSLL 1265

  Fly   875 EEIQSENTKLAER-NCLLEEQTNHLESQLQAKQD-------------------------EIGKIQ 913
            ||:.|:.....|| ..|||.:||.|....:.|.|                         ::.:::
Mouse  1266 EELASQLDSRCERTKALLEAKTNELVCTSRDKADAILARLSQCQRHTATVGEALLRRMGQVSELE 1330

  Fly   914 AKLQQVLDEHSKLQNA-QELMDH-DHRTLQDKCDAYEKDKLLTKHTLDCLQ-------SASEELH 969
            |:|.|:.:|...|::: |::.:. :.:..|.|....:.:.|||:.  :.||       .|:.|..
Mouse  1331 AQLTQLTEEQRTLKSSFQQVTNQLEEKEKQIKTMKADIEGLLTEK--EALQQEGGQQRQAASEKE 1393

  Fly   970 RVKANLDRELKEQDQQLSELRERQREQEQQL--------------------KDQAERCAKLKAQN 1014
            .....|.:||.|....::.|||...|::.::                    .|:||..:.|..|:
Mouse  1394 SCITQLKKELAENINAVTLLREELSEKKSEIASLSKQLSDLGAQLESSISPSDKAEAISALSKQH 1458

  Fly  1015 SESETQLQATISNLREQLDAYKQTEQGIQE--------------KLQATNSSYTTQIATLEARWS 1065
            .|.|.||||.:..|..::||..:.:....|              |.|:..:.:.:.|..|:|:..
Mouse  1459 EEQELQLQAQLQELSLKVDALSKEKMSALEQVDHWSNKFSEWKKKAQSRLAQHQSTIKDLQAQLD 1523

  Fly  1066 A--------------ANSDVERLHEANDALQLEMEQLKIKHGQEREEVKESIAQKNRQVVELQEA 1116
            .              ...|::|.::..:.|:.|||..|.|..::..:::.::..:..:||||::.
Mouse  1524 VKATDAREKEEQICLLKEDLDRQNKKFECLKGEMEVRKSKMEKKECDLETALKTQTARVVELEDC 1588

  Fly  1117 MATRDRQLQ---------------------------EKI--EASEKLAKFDEILIENEYLNKHTK 1152
            :..|.::::                           |::  |...|:.:.:|.::.   |.:|..
Mouse  1589 VTQRKKEVESLNETLKNYNQQRDTEHSGLVQRLQHLEELGEEKDNKVREAEETVLR---LREHVS 1650

  Fly  1153 QLEAELA----ESAELKEKLKSLQCELYVLQEKAE----------------------QHAVQMAE 1191
            .|||||.    |...:...:||...||..|::|.|                      |...||.|
Mouse  1651 SLEAELGTVKKELEHVNSSVKSRDGELKALEDKLELESAAKVELKRKAEQKIAAIRKQLLSQMEE 1715

  Fly  1192 K--------ETQSATATAEVSELKKAI--------------------------------EEQA-- 1214
            |        |.:.:..:|::.|.:|.:                                |::|
Mouse  1716 KTQRYAKDTENRLSELSAQLKEREKQVHSLEDKLKNLESSPHPEVPAVSRSMQSVAASPEQEAPD 1780

  Fly  1215 ----------------------------------------------------VELTR-------- 1219
                                                                ::.||
Mouse  1781 SQDCTHKACKERLCMLQRRLSEKEKLLRRLEQGEGEARPSQPEAQHRALSGKLDCTRARQLEDHV 1845

  Fly  1220 ----------QKEHASFVTEQS-------------------DAVQKDL------LQAQQQ----- 1244
                      :|...|.:..|.                   |:|||.|      .||.:|
Mouse  1846 LIGCLPEELEEKMKCSLIVSQPMGEETGNNTGVKQNWASVVDSVQKTLQEKELTCQALEQRVKEL 1910

  Fly  1245 ---------LHDKQIE-LAMSRDEQALLQAEADGLRQEVICLKEHLSPSTDS----------DSL 1289
                     .|..::| |.:..::....|.|.||..:.|..|::....::.|          |.|
Mouse  1911 ESDLVRERGAHRLEVEKLTLKYEKSQSSQQEMDGENKCVEVLEDRPEENSQSHEIQSNVGTVDGL 1975

  Fly  1290 RSLNE------------------RLQRELEDLKHK------------SAGAESNMQQEIEELQAN 1324
            ||..|                  |||:||..|:.:            ...||..::||.|:|:..
Mouse  1976 RSDLESKLTGAERDKQKLSKEVARLQKELRALRREHQQELDILKRECEQEAEEKLKQEQEDLELK 2040

  Fly  1325 ------------NQQMAERINELE-TLRAGI-QAQQLLASMAPKNVQEAAAAGEK-AELESKLK- 1373
                        |.|:|::..||| |::..| :||::.|.:...:.:|......| ||.|..|:
Mouse  2041 HTSTLKQLMREFNTQLAQKEQELERTVQETIDKAQEVEAELLESHQEETQQLHRKIAEKEDDLRR 2105

  Fly  1374 --------------EIMNEVQDVTNRNLFLEQKCENFLILEQSNER----LKLQ----------- 1409
                          |:..:|.|:..:...|::|.:..|..|:|.:.    |:||
Mouse  2106 TARRYEEILDAREEEMTGKVTDLQTQLEELQKKYQQRLEQEESTKDSVTILELQTQLAQKTTLIS 2170

  Fly  1410 NAKLSRQ--------LDETLV------------------SMQHSEA--VPANTEFEYLRNIMFQY 1446
            ::||..|        |::.|.                  ::.|:|.  ....|||||||.:||:|
Mouse  2171 DSKLKEQELREQVHNLEDRLKRYEKNACAATVGTPYKGGNLYHTEVSLFGEPTEFEYLRKVMFEY 2235

  Fly  1447 LTGNTNNETLVKVISAVLKFSPQQAQVALEKEHQR 1481
            :.|. ..:|:.|||:.||||...|||..||:|..|
Mouse  2236 MMGR-ETKTMAKVITTVLKFPDDQAQKILEREDAR 2269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Golgin245	NP_611787.2	Smc	286..1089	CDD:224117	259/1215 (21%)
		Phage_GPO	<306..421	CDD:301727	29/134 (22%)
		Smc	737..1442	CDD:224117	233/1238 (19%)
		MIT_CorA-like	<1244..>1333	CDD:294313	31/155 (20%)
		Grip	1433..1477	CDD:197860	23/43 (53%)
Golga4	XP_036010996.1	SMC_prok_B	197..1046	CDD:274008	196/873 (22%)
		Smc	733..1532	CDD:224117	167/821 (20%)
		Smc	<1501..2188	CDD:224117	120/689 (17%)
		Grip	2222..2265	CDD:197860	23/43 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837702
Domainoid	1	1.000	288	1.000	Domainoid score	I1570
eggNOG	1	0.900	-	-		E1_28M43
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2810
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007308
OrthoInspector	1	1.000	-	-		oto94851
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19327
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5799
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.970