Protein Alignment Golgin245 and Cenpe

DIOPT Version :9

• Sequence 1: NP_611787.2
• Gene: Golgin245 / 37702
• FlyBaseID: FBgn0034854
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: XP_038959788.1
• Gene: Cenpe / 362044
• RGDID: 1307115
• Length: 2456
• Species: Rattus norvegicus
• Alignment Length: 1717
• Identity: 378/1717 - (22%)
• Similarity: 703/1717 - (40%)
• Gaps: 403/1717 - (23%)

  Fly     4 NLKNKLIEEVKASPSKFQQFANAAQAAVSSSSSTTP-----NSETNTSNNENFFSITEEDTPQNS 63
            :|:|:|..:|:....|..|.....:...:..|.||.     :||......:...::::.||
  Rat   575 DLENELSSKVELLKEKEDQIKELQRYIDAQKSETTKTDLSYSSEATEDLKQAMRTLSDLDT---- 635

  Fly    64 PYRIQKLPATSASA-LRGRSTQSLNGATSRTRKLSNSSMASDVSFRLPTYEAPAVYHLQSDLD-E 126
                ..|.|...|| ||..:.:    ...|..:||:|....:...::...:..|...:|:||: |
  Rat   636 ----VALDAKRESAFLRSENLE----LKERINELSDSCKQMENGIQMYQRQLEAKKQVQADLEKE 692

  Fly   127 TSSEFDD-SASTARLDVITKDQLYDAYKKSLDRYHKYRCRYTDLAKKY-KELERDSSKARSVLVE 189
            ....|.: |..:|.:|           .|.|....:...|.|||.|:. ||:|..         |
  Rat   693 LQLAFQEISKLSALVD-----------GKGLLSNLELEKRITDLQKELNKEVEEK---------E 737

  Fly   190 TQDKALRRISELR----EQCTLEQQAKAHLEEALRVEMD------DMSCKMQAYQTKLQLLGENP 244
            |..|.:..:|||:    |..||.::.....||...:..:      :|:.|....|..|:.:|...
  Rat   738 TLQKEVHLLSELKSLPSEVETLRRELHEKSEELCVITTEREKLFSEMAHKDSRIQGLLEEIGNTK 802

  Fly   245 ENITA-------------ALE--------RSGQQLESEQLIDLEESIGKSPLSTNGSSG------ 282
            :::.|             ||:        |..:.||..:.:..|.|.....|:...:.|
  Rat   803 DDLAASQLSQRSSDEECQALKSLHVELKHRQEEVLEESERVKQELSQKTQELAQKTAEGQEMLNQ 867

  Fly   283 VSDLQRLLKERDEQLKSVTEKYEAVRKQEEENVLL--LAQTKQAIHTELELKDTEVRKLQEKLKQ 345
            :.:|:..|:.||..|:|.         ::|:|:|.  |.||.:.:.. |..:..::::|||.|:.
  Rat   868 MEELREKLERRDSSLQSA---------EKEKNLLTEKLQQTLEEVRA-LTQEKNDLKQLQESLQT 922

  Fly   346 LESQRESH-------NNEVKEQ-FKKLQATKQEVDA----KLMATEHLLNTLKESYAIK--EQQV 396
            ...|..|.       |.:.:|| ...|::.||..:.    |:.|||.:.:.|    .||  |...
  Rat   923 ERDQLRSDIQDTVNMNIDTQEQLLNALESLKQHQETINMLKMKATEEMSDHL----PIKGREGSS 983

  Fly   397 VTLEAQLEAIRVEN--------------------EQKVKDLQKQNEDRNTQASDS----SEQLK- 436
            ..:|.:|:.|..||                    ||:..|...|...|..|..:|    .||||
  Rat   984 DEVEQKLDGIDEENLLAESAHTVVGSGEDHGETEEQRKIDSLLQENSRLQQTLESIIAEKEQLKM 1048

  Fly   437 ----KLQAAVQDAESQLLSKDQLLESLRSEQAAKEQQLKHLKEQLGKLKQENENYLDKLRENKKS 497
                .::.:|::.|...:.:|:    |:.:|....|:..|:.|:..:|.:.:|. |.::.|..|.
  Rat  1049 DLKENIEMSVENQEELRILRDE----LKRQQEIAAQEKDHVTEKSEELSRAHER-LAEIEEKLKE 1108

  Fly   498 SDSQTNEAQDQQKKLQAAKDEAESKLLATEELLHSLRNDYKAQEEKVALLEDKLKTLSKENDVNV 562
            .:.:..|.|.|...:|.|..|.::|:...|.|.:..||...|.|.    :|.:...|:::...|.
  Rat  1109 KNQKLQETQQQLVSIQEAMSEMQAKVTDLENLQNEFRNQALALER----VETERLELAQKLHENY 1169

  Fly   563 EKLHHI----NEQREAQSTDSQQKINELRAAKDEAEAKLLSTEHSLNALQAALSAKEEQAASLEQ 623
            ||:..|    |:.:|.|.:...:| .:|:....|.|:..|.|:..||...|.|...:|....|..
  Rat  1170 EKMESITKERNDLKELQESFEIEK-KQLKEYAREMESAGLQTKEQLNIAHANLKEYQEIIKELRG 1233

  Fly   624 SLNALKTESEHSLQDLRLHN--DQLLEIVQRHQQNDWEAQLARAR----EELAAIQSQR------ 676
            |::..:.::. |.||....|  .|....|.|.|:...:|:.|||.    .||..::...
  Rat  1234 SISEKEAQAS-STQDTGKTNPASQGETPVPREQELLPDAEEARASAEKGSELEPVEEHSRTAHSL 1297

  Fly   677 -----ELHALELEKSLEMERESVAALNSEKAS-QEEQHRLKLE--QLQREIQILQDQHANSESET 733
                 |:..|.|.|.||..::.::.|..|::. :..|..|::|  ||:.:.:.....|..:|.|.
  Rat  1298 TTEGIEMEILALTKKLEESQKEISCLTKERSDLRRTQEALQVECAQLKDDARRTLANHLETEEEL 1362

  Fly   734 VAA---LKGQ---LEALSQDLATSQASLLAKEKELKASGNKLNK-----IKKQHEQHQAKSSDQS 787
            ..|   ||.|   :::|...|:..:|.|.:...:|:.:..:|.:     .:||.:.:..::|:..
  Rat  1363 SLARCCLKEQENKIDSLIVSLSQKEAELSSVRVQLEVTTGELERKVQELCEKQEQLNIKETSEVQ 1427

  Fly   788 ARL--------------EALQSELADRLSHSRQVESEKEELQARVTGILEEIGTMQAQMQQVQDS 838
            .::              .||||..:|||..::|:|..:||::.    :::|    :.::::.|::
  Rat  1428 GKMSELDHIRALLLTKDSALQSVESDRLRLNKQLEESQEEIKI----LIKE----REELRRAQEA 1484

  Fly   839 -HSELEREK---RKLESRIESLQQEQV-----------------DSSAQDERTSAKLEEIQSENT 882
             |.|.|:::   :::.:|::.||.::.                 |.:.|.|...:.||:::.:|.
  Rat  1485 LHVEREQQQESIKEISTRLQELQDKEYEYLVMKSLNETQGNKCEDLNQQLEAQKSSLEKVEMQNV 1549

  Fly   883 KLAER-NCLLEE---------QTNHLESQLQAKQDEIGK-IQAKLQQVLDE-------HSKLQNA 929
            .|.:| |..|||         :...:|.:|.|.:|::.| ::..:.:.|::       |..||..
  Rat  1550 NLTQRLNETLEEMKSVAKERDELRSVEERLTADRDQLKKSLEETITKGLEKEEELRVAHMHLQEH 1614

  Fly   930 QELMDHDHRTLQDKCDAYEKDKLLTKHTLDCLQSASEELHRVKANLDRELKEQDQQLSELRERQR 994
            ||.::...:::.|..|.........:||...:....|..|   ||  :||:|:..|||:::...|
  Rat  1615 QETINELRKSVSDCTDEIAHIHGDLEHTHAVIHGDLEHTH---AN--QELQEKGHQLSQVKADLR 1674

  Fly   995 E---QEQQLKDQAERCAKLKAQNSESETQLQATISNLREQLDAYKQTEQGIQEKLQATNSSYTTQ 1056
            |   |.:|||:|      |:||||        |:.::  :::..|.|:| :.|.|:.
  Rat  1675 ETMDQMEQLKEQ------LEAQNS--------TLESI--EIEKLKLTQQ-LNENLKE-------- 1714

  Fly  1057 IATLEARWSAANSDVERLHEANDALQLEMEQLKIKHGQEREEVKESIAQKNRQVVELQEAMATRD 1121
             .||.|:             .||.|::..|.|:    :||::::||:.|.....:|.||.:
  Rat  1715 -MTLVAK-------------ENDDLKIMDEALR----EERDQLRESLRQTEASDLEKQEKL---- 1757

  Fly  1122 RQLQEKIEASEKLAKFDEILIENEYLNKHTKQLEAELAESAELKEKLKSLQCELYVLQEKAEQHA 1186
                       ::|..|        |.:|.:.:|..:...|:..|::..:..||.....:.::..
  Rat  1758 -----------RIAHLD--------LKEHQETIERLMGSVAKRTEEVSDMNMELERANTRLQEKV 1803

  Fly  1187 VQMAEKETQSATATAEVSELKKAIEEQAVELTRQKEHASFVTEQSDAVQKDLLQAQQQLHDKQIE 1251
            .::...|.|...:..|..|.||.::||.:.|::              ::.:.|...||:|....|
  Rat  1804 QELKASELQLLKSKVEAGETKKQLKEQGLALSK--------------IEMENLNLAQQIHQNLEE 1854

  Fly  1252 LAMSRDEQALLQAEADGLRQEVICLKEHLSPSTDSDSLRSLNERLQRELEDLKHKSAGAESNMQQ 1316
            :.....|:..|:...:.||.|    |:.|     .||||....:..:..|:......|.....:|
  Rat  1855 MKSISKERDDLKRMEEILRME----KDQL-----KDSLREAKFKAHQNYEETVQYGKGLLCGGEQ 1910

  Fly  1317 -----------EIEEL------QANNQQMAERIN---ELET-----LRAGIQAQQLLASMAPKNV 1356
                       .||:|      .||:.:...|.:   |.||     |...|:.:..|.....|.:
  Rat  1911 HCTGRLREKCLRIEKLLKRYSEMANDYECLNRFSLDLEKETKTQKELSVTIKTKLSLPYTQTKEI 1975

  Fly  1357 QEAAAAGEKAELE-----SKLKEIMNEVQDVTNRNLFLEQKCENFLI--LEQSNE-RLKLQN--- 1410
            ::...|.::..:|     .|||.:::.:..:.........|.|...|  :|:.|| ::|:|:
  Rat  1976 EKLLTANQRCSMEFHRILKKLKYVLSYITRIKEEQHEFINKFEMAFIQEVEKQNELQIKIQSLSQ 2040

  Fly  1411 ----------AKLSRQLD----ETLVSMQHSEAVPANTEFEYLRNIMFQYLTGNTNNETLVKVIS 1461
                      :|||:::|    |.|.....::.:...||.:       |.|   :|.:.:.:.:.
  Rat  2041 TSNIPSRDSQSKLSQEMDLHIEEILKDFSENDFLTIKTEVK-------QVL---SNRKEITEFLE 2095

  Fly  1462 AVLK--FSPQQAQVALEKEHQRRSLLN 1486
            ..|.  |..:..:.:::||::...|:|
  Rat  2096 KWLNTHFDTENLKSSIQKENKSIGLVN 2122

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Golgin245	NP_611787.2	Smc	286..1089	CDD:224117	221/938 (24%)
		Phage_GPO	<306..421	CDD:301727	35/150 (23%)
		Smc	737..1442	CDD:224117	173/818 (21%)
		MIT_CorA-like	<1244..>1333	CDD:294313	23/105 (22%)
		Grip	1433..1477	CDD:197860	7/45 (16%)
Cenpe	XP_038959788.1	KISc_CENP_E	6..329	CDD:276825
		Smc	<334..1057	CDD:224117	117/527 (22%)
		Smc	787..1603	CDD:224117	191/848 (23%)
		Smc	1320..2167	CDD:224117	193/915 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000