DRSC/TRiP Functional Genomics Resources

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Protein Alignment Golgin245 and GOLGB1

DIOPT Version :9

Sequence 1:NP_611787.2 Gene:Golgin245 / 37702 FlyBaseID:FBgn0034854 Length:1489 Species:Drosophila melanogaster
Sequence 2:NP_001243415.1 Gene:GOLGB1 / 2804 HGNCID:4429 Length:3269 Species:Homo sapiens


Alignment Length:1819 Identity:390/1819 - (21%)
Similarity:744/1819 - (40%) Gaps:429/1819 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 IEEVKASPSKFQQFANAAQAAVSSSSSTTPNSETNTSNNENFFSITEEDTPQNSPYRIQKLPATS 74
            :.::||...:.:......:..|||::|..      |..:|..|.:.|:...|.  ..|:.|...|
Human  1309 VAQIKAQLKEIEAEKVELELKVSSTTSEL------TKKSEEVFQLQEQINKQG--LEIESLKTVS 1365

  Fly    75 ASA-LRGRSTQSLNGATSRTRKLSNSSMASDVSFRLPTYEAPAVYH---LQSDLDETS------- 128
            ..| :...|.|         :||.:|.:           :...:.|   ||..|||..       
Human  1366 HEAEVHAESLQ---------QKLESSQL-----------QIAGLEHLRELQPKLDELQKLISKKE 1410

  Fly   129 ----------SEFDDSASTARLDVITKDQLYDAYKKSL--------DRYHKYRCRYTDLAKKYKE 175
                      ||.:.:.:..:.::|.::.|..|....|        :|..:.:....::.:|.:|
Human  1411 EDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEE 1475

  Fly   176 LERDS-------SKARSVLVETQDKALRRISELREQCTL---------------EQQAKAHLEE- 217
            :..:|       .|.::.|: ::.:||:....|:|:.:|               |.|..|..:| 
Human  1476 IGEESRAKQQIQRKLQAALI-SRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEK 1539

  Fly   218 --------ALRVEMDDMSCKMQAYQTKLQLLGENPENITAALERSGQQLESEQLIDLEESIGKSP 274
                    .|:.|.|.:..:|.....:.|.|..:.|::..|||  |...:.|:|:...||:..|.
Human  1540 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALE--GLTEDKEKLVKEIESLKSSK 1602

  Fly   275 LSTNGSSGVSDLQRLLKERDEQLKSVTEKYEAVRKQEE--ENVL-LLAQTKQAIH-----TELEL 331
            ::.:     ::.|...||..::.:.:.:.||.|..:.|  ::|: .:.|.||.::     ||...
Human  1603 IAES-----TEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1662

  Fly   332 KDTEVRKLQEKLKQLESQRESHNNEVKEQFKKLQATKQEVDAKLMATEHLL-NTLKESYAIKEQQ 395
            |:|| ::|||..:::|..:|......|.:.:|:...::|.| :|.|..|.. :|.||........
Human  1663 KETE-KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND-RLRAEVHPAGDTAKECMETLLSS 1725

  Fly   396 VVTLEAQLEAIRVENE-----------------QKVKDLQKQ-------------NEDRNTQASD 430
            ..:::.:||.:::|.|                 ::|:||:.|             .|..:.|.:.
Human  1726 NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNV 1790

  Fly   431 SSEQLKKLQAAVQDAESQLLS-KDQLLESLRSEQAAKE----------------QQLKHLKEQLG 478
            :.|..:.:....::.:|..:| :....||:.|.::|..                ||:..|||::.
Human  1791 TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIA 1855

  Fly   479 KL---KQENENYLDKLRENKKSSDSQTNEAQDQQKKLQ--------------------------- 513
            .|   ||:|:.:...|...|.:..||.:....:.|.||                           
Human  1856 GLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETA 1920

  Fly   514 -AAKDEAESKLL-ATEELLHSLRN---DYKAQEEKVALLEDKLKTLSK-ENDVNVEKLHHINEQR 572
             ..||:.|.:|: ...||..|:.|   |....:.|..|||.::|.|.| .:::..||...:.|:.
Human  1921 EEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKT 1985

  Fly   573 EAQSTDSQQKINELRAAKDE----AEAK-----LLSTEHSLNALQAALSAKEEQAASLEQSLNAL 628
            :.:|...::.:.:::.|:.|    :.||     |...:..:..||......:|:.::||:::.||
Human  1986 KVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKAL 2050

  Fly   629 KTESEHSLQDLRLHNDQLLEIVQRHQQNDWEAQLARAREELAAIQSQRELHALELEKSLEMERES 693
            :.....|.:||.:..:.|.:.|:..::.  :|:||..:..|...||:.   |..|..:|::::| 
Human  2051 EFVQTESQKDLEITKENLAQAVEHRKKA--QAELASFKVLLDDTQSEA---ARVLADNLKLKKE- 2109

  Fly   694 VAALNSEKASQEEQHRLKLEQLQREIQILQDQHANSE---SETVAALKGQLEALSQDLATSQASL 755
               |.|.|.|.:.|.:.|.|.|:|.::..:::|...:   .|.:.||:.:...|.:.:...|.:|
Human  2110 ---LQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2171

  Fly   756 LAKEKELKASGNKLNKIKKQHEQH-QAKSSDQSARLEALQSELADRLSHSRQVESEKEELQAR-- 817
            ..|:||::.....|:....|.... ::.||.|..|...:..........|..::|::||::.:  
Human  2172 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKED 2236

  Fly   818 -VTGILEEIGTMQAQMQQVQDSHSELEREKRKLESRIES---LQQEQVDSSAQDERTSAKLEEIQ 878
             .:.:.:::..|...|::::.:.|.||.:|:..||:.::   |||:..|:             :|
Human  2237 NCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT-------------LQ 2288

  Fly   879 SENTKLAERNCLLEEQTNHLESQLQAKQDEIGKIQAKLQQVLDEHSKLQNAQELMDHDHRTLQDK 943
            .||.:|..:   ||| |.||   ..:.|:|:.|::::|:.:.|:.:.|.|:.|........|:..
Human  2289 GENKELLSQ---LEE-TRHL---YHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGI 2346

  Fly   944 CDAYEKDKLLTKHTLDCLQSASEELHRVKANLDRELKEQDQQ---------------LSELRERQ 993
            ....|.|...:|.:.:.|::..:....:.:.|..|:..::|:               ::|||::.
Human  2347 IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH 2411

  Fly   994 ----REQEQQLKDQAERCAKLKAQNS---ESETQLQATISNLREQLDAYKQTEQGIQEKLQATNS 1051
                :|.|..|..:.|....|:.:|.   :...||..|:..::         ::.||:|.|.  .
Human  2412 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIK---------KENIQQKAQL--D 2465

  Fly  1052 SYTTQIATLEARWSAANSDVERLHEANDALQLEMEQLKIKHGQEREEVKESI------------- 1103
            |:...:::|:........|.::|.|.:.::.||.:||..:...|..::||.|             
Human  2466 SFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE 2530

  Fly  1104 -AQKNRQVV----ELQEAMATRDR--------QLQEKIEASEKLAKFDEILIENEYLNKHTKQ-L 1154
             |:.:.:::    :|.:.:..:|.        |||:..|...|.||.:|.|.|:|..|:..:: .
Human  2531 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSF 2595

  Fly  1155 EAELAESAELKEKLKSLQC-------ELYVLQEKAE---QHAVQMAEKETQSATATAEVSELKKA 1209
            .|...|..:|.::::||:.       ::..|||:..   .|| |:..||.:....:|..|..:|.
Human  2596 NALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHA-QLKVKEEEVHRLSALFSSSQKR 2659

  Fly  1210 IEEQAVELT-RQKEHASFVTEQSDAVQK----------------------------DLLQAQQQL 1245
            |.|...||. .|||.|..|.|..|.::|                            ||::.:|:|
Human  2660 IAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL 2724

  Fly  1246 -----HDK----QIE--------LAMSRD------------------------EQALLQAEADGL 1269
                 .:|    ||:        |..|||                        ||.||..|.|.|
Human  2725 LMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDAL 2789

  Fly  1270 RQEVICLKEHLSPSTDSDS---LRSLNERLQRELEDLKHKSAGAES--NMQQEIEELQANNQQMA 1329
            ..|......    ||:.:|   |..||::|..:.|.|.|.|:..|.  |..|...:..|:.|...
Human  2790 LSETAFSMN----STEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNER 2850

  Fly  1330 ERI-NELETLRAGIQAQQLLA---SMAPKNVQ--EAAAAGEKAELESKLKEIMN----------- 1377
            :.: ||||..|...:.:|..|   |.:|..||  :.|.:..:.:.:..|||:.|           
Human  2851 DHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE 2915

  Fly  1378 ------------EVQDVTNRNLFLEQKC--ENFLILEQSNERLKLQNAKLSRQLDETLVSMQHSE 1428
                        |.||.|.....::::.  ||   |...:|..:|:..|.|.::.|..:..|:..
Human  2916 ITELHPLKAQLQEYQDKTKAFQIMQEELRQEN---LSWQHELHQLRMEKSSWEIHERRMKEQYLM 2977

  Fly  1429 AV-PANTEFEYLRNIMFQYLTGNTNNETLVKV-----ISAVLKFSPQQAQVALEKEHQRRSLLN 1486
            |: ..:.:..:|:|::.:..:.::..:.| ||     .|.....||..:|..:.:....|:.||
Human  2978 AISDKDQQLSHLQNLIRELRSSSSQTQPL-KVQYQRQASPETSASPDGSQNLVYETELLRTQLN 3040

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Golgin245NP_611787.2 Smc 286..1089 CDD:224117 202/935 (22%)
Phage_GPO <306..421 CDD:301727 34/153 (22%)
Smc 737..1442 CDD:224117 193/877 (22%)
MIT_CorA-like <1244..>1333 CDD:294313 32/135 (24%)
Grip 1433..1477 CDD:197860 9/48 (19%)
GOLGB1NP_001243415.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..142
SMC_prok_B 223..1038 CDD:274008
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..657
Smc 814..1650 CDD:224117 73/376 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 949..968
Ax_dynein_light <1160..1223 CDD:287215
Myosin_tail_1 1394..2326 CDD:279860 209/970 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1752..1834 13/81 (16%)
SMC_prok_B 1904..2778 CDD:274008 197/914 (22%)
SMC_prok_B 2459..3192 CDD:274008 136/593 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2861..2881 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3003..3026 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3117..3150
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
10.960

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