DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Golgin245 and Cenpf

DIOPT Version :9

Sequence 1:	NP_611787.2	Gene:	Golgin245 / 37702	FlyBaseID:	FBgn0034854	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_001094297.1	Gene:	Cenpf / 257649	RGDID:	628667	Length:	2985	Species:	Rattus norvegicus

Alignment Length:	1762	Identity:	374/1762 - (21%)
Similarity:	704/1762 - (39%)	Gaps:	427/1762 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NLKNKLIEEVKASPSKFQQFANAAQAAVSSSSSTTPNSETNTSNNENFFSI-TEEDTPQNSPYRI 67
            |.||:| |::|.:.:|.||            ...|..:.|...|.:....: ||..|.::....|
  Rat  1060 NKKNEL-EQLKETFAKEQQ------------EFLTKLAFTEEQNRKLVLELETEPQTVRSEITNI 1111

  Fly    68 QKLPATSASALRGRSTQSLNGATSRTRKLSNSSMASDVSFRLPTYEAPAVYHL-----QSDLDET 127
            .|.|.:...||...|..|......:.:::||.:..::....| |......|||     ::.:..|
  Rat  1112 NKHPVSETDALGQESWSSKEEQKEKQKEVSNLTPENEQLMEL-TQTKHDYYHLEVEPVENSVKAT 1175

  Fly   128 SSEFDDSASTARLDVITKDQLYDAYKKSLDRYHKYRCRYTDLAKKYKELERDSSKARSVLVETQD 192
            ..|...|:|..::|:.|||...|:||..|.:        .:...|..|::.|.|       |.:.
  Rat  1176 EEEIRKSSSQYQMDIDTKDISLDSYKAQLVQ--------LEALIKVMEVKLDRS-------EEEK 1225

  Fly   193 KALRR-ISELREQC------TLEQQAKAHLEEALRVEMDD------------------MSCKMQA 232
            .:||: :..:||:.      ..:.||:..|::. .||.::                  :.|.:|.
  Rat  1226 NSLRQELQTIREELGTKTSQDTQSQARVGLKDC-EVEAEEKYVSVLQELSTSQNENVHLQCSLQT 1289

  Fly   233 YQTKLQLLGENPENITAALERSGQQLESEQLIDLEESIGKSPLSTNGSSGVSDLQRLLKERDEQL 297
            ...||..||:..|    .|.....|||||    |.:|  :|...|..|...:::::|:.|
  Rat  1290 AMNKLNELGKMCE----VLRVEKLQLESE----LNDS--RSECITATSQMAAEVEKLVNE----- 1339

  Fly   298 KSVTEKYEAVRKQEEENVLLLAQTKQAIHTELELKDTEVRKLQEK-------LKQLES--QRESH 353
                     ::....||.|        .|.|| :|||...:..:|       |..|::  |..|.
  Rat  1340 ---------MKMLNHENAL--------SHGEL-MKDTADVEFDDKPNHTSVFLTPLDNSEQMTSS 1386

  Fly   354 NNEVK-------EQFKKLQATKQ-------EVDAKLMATEHLLNTLKESYAIKEQQVVTLEAQLE 404
            |.||:       |:|..||:..:       ||.:|:.|....::|||...::....:.||:..|
  Rat  1387 NKEVRVHFAELQEKFSCLQSEHKILHDQHCEVSSKMSALRSYVDTLKAENSVLSMNLRTLQGDL- 1450

  Fly   405 AIRVENEQK----------------------------VKDLQKQNEDRN---------------T 426
               |:.::.                            .||:.:|..|.:               .
  Rat  1451 ---VKEKEPGAEDGHILPLSFCRTDSPTLTNFGENSFYKDVLEQTGDTSHLSLEGNASANPCDVD 1512

  Fly   427 QASDSS------------------------------EQLKKLQAAVQDAESQLLSKDQLLESLRS 461
            :.|.||                              :.:|.|:..:   |||.:.|::.:|.|..
  Rat  1513 EVSYSSLEEENLTEKEIPFASLRTVEELEILCQVYLQSIKNLEEKI---ESQRIMKNKEIEELEQ 1574

  Fly   462 EQAAKEQQLKHLKEQLGKLKQENENYLDKLRENKKSSDSQTNEAQDQQK---------KLQAAKD 517
            ..:::.::|..|::|   ...|.|.:..||.......:|:..|.:.|.|         :||..:.
  Rat  1575 LLSSERKELSCLRKQ---YLSEKEQWQQKLTSVTLEMESKLAEEKQQTKNLSLELEVARLQLQEL 1636

  Fly   518 EAESKLLATEELLHSLR--ND-YKAQEEKVALLEDKLKTLSK------ENDVNVEKLHHINEQRE 573
            :..|:.|...:|..::|  || |..:|.:|.:.|...||..:      :|||. :.|.......|
  Rat  1637 DLSSRSLLGTDLEGAVRGPNDGYAIKESEVYISETTEKTPKQDTNQTCDNDVQ-QDLCLETSVTE 1700

  Fly   574 AQST--------DSQQKINELRAAKDEAE--AKLLSTEHSLNALQAALSAKEEQAASLEQSLNAL 628
            .::|        :...||:....|:|..:  ::.:|...|..::...:...|:|.     |:..|
  Rat  1701 TETTRLTGDGCEEQPSKISCEAPAEDRTQDYSECISELFSTPSVLVPMDVLEDQG-----SIQNL 1760

  Fly   629 KTESEHSLQDLRLHNDQLLEIVQRHQQNDWEAQLARAREELAAIQSQRELHALELE--------- 684
            ..:.:.|.::|||    |.|:      .||:.::.....|:....|:..|..|:|:
  Rat  1761 HLQKDTSNENLRL----LPEV------EDWDKKVESLLNEIKEADSKLSLQELQLKIKIATCIEL 1815

  Fly   685 ----KSLEMERESVA-ALNSEKASQEEQHRLKLEQLQREIQILQDQHANSESETVAALKGQLEAL 744
                |.|:.|...:: .|.|...:||...|::...|...:.:..|:...             |:.
  Rat  1816 EKIVKHLKKEETDLSEKLESLPCNQEVCPRVERSDLDFNLDMGDDELFR-------------EST 1867

  Fly   745 SQDLATSQASLLAKEKELKASGNKLNKIKKQHEQHQAKSSDQSARLEALQSELADRLSHSRQVES 809
            ..|.|.::.:.  |||.|... .:|.:||.:....:.......|.||.:|   |::|...|..||
  Rat  1868 KDDAANTEDNY--KEKFLDME-RELTRIKSEKANIEHHIVSVKANLEVVQ---AEKLCLERDTES 1926

  Fly   810 EKE---ELQARVTGILEEIGTMQAQMQQVQDSHSELEREKRKLESRIESLQQEQVDS----SAQD 867
            :::   :|:..:..::.|...::.::..|......|::..:|::.:||.|:..|.:|    .|.:
  Rat  1927 KQKVIVDLKGELFTVISERNRLREELDNVSKESKALDQMSKKMKEKIEELESHQRESLHHIGAVE 1991

  Fly   868 ERTSAKLEEIQSENTKLAERNCLLEEQTNHLESQLQAKQDE-------IGKIQAKLQQVLDEHSK 925
            .....|.|.||:.:..:.|    |.:...||:.|||..|::       ||:::.::.|:..|...
  Rat  1992 SEVKDKAELIQTLSFSVDE----LTKDKAHLQEQLQNLQNDSQGLSLAIGELEIQIGQLNKEKES 2052

  Fly   926 LQNAQELMDHDHRTLQDKCDAYEKDKLLTKHTLD------CLQSASEELHRVKANLDR------- 977
            |  .:|..:...:..:.:|:.....|.|....::      .|.|..||:|:::..:::
  Rat  2053 L--VKESQNFQVKLTESECEKQTISKALEVALMEKGEFAMRLSSTQEEVHQLRQGIEKLSVRIEA 2115

  Fly   978 ELKEQDQQLSELRERQREQEQQLKDQA---ERCAKLKAQNSE----SETQLQATISNLREQLDAY 1035
            :.|:....:::|:|.|||.: .|||:.   ||..::..:|.|    ....|:|.:..|:.|:|..
  Rat  2116 DEKKHLSAVAKLKESQRESD-SLKDKVENLERELEMSEENQELAILDSENLKAEVETLKAQMDEM 2179

  Fly  1036 KQTEQGIQEKLQATNSSYTTQIATLEARWSAANSDVERLHEANDALQLEMEQLKIKHGQEREEVK 1100
            .::.:..:..|....|........|:.:.|.. |:::.|..:..:|..|.||.:::  .||:. |
  Rat  2180 AKSLRVFELDLVNVRSERENLAKQLQEKQSRV-SELDELCSSLRSLSEEKEQARVQ--MERDS-K 2240

  Fly  1101 ESIAQKNRQVVELQEAMATRDRQLQEKIEASEKL--AKFDEILIENEYLNKHTKQLEA------- 1156
            .::.....|:.||.|.:|..... ||.::|.|:.  ...:|:.:....:.|....::|
  Rat  2241 SAMLMLQTQLKELWEEVAALYND-QETLKAQEQSLDQPGEEVHLLKSSIQKLKVHIDADKKKQCH 2304

  Fly  1157 ---ELAES---AEL-KEKLKSLQCELYVLQEKAEQHAVQMAE-KETQSATATAEVSELKKAIEEQ 1213
               :|.||   |:| |:::::|:.|| :|.||.::|.:..|| .:.:..|...|:..:.:.:::.
  Rat  2305 ILEQLKESKHHADLFKDRVENLEQEL-MLSEKNKEHLIFQAENSKAEIQTLKTEIQTMDQNLQDL 2368

  Fly  1214 AVELTRQKEHASFVTEQSDAVQKDLLQAQQQ--------------LHDKQIELAMSRDEQ----A 1260
            .:|||..:       .:.:.:.|:|...|:|              |.||:.|....::|.    .
  Rat  2369 ELELTNTR-------SEKENLMKELKNEQEQISKLETINSSIERLLTDKEQEKVQVKEEARITVE 2426

  Fly  1261 LLQAEADGLRQEVICL-KEHLSPSTDSDSLRSLNERLQRE----LEDL---KHKSAGAESNMQQE 1317
            :||.:...|.:.|:.| .:..:..|...:|.|..:.|:.|    |:||   |:|....:|::...
  Rat  2427 MLQTQLKELNETVVSLCNDQEAYKTKEQNLGSRVQTLELEKAQLLQDLGEAKNKYIIFQSSVNAL 2491

  Fly  1318 IEELQANNQQMAERINELETLRAGIQAQ-QLLASMAPKNVQEAAAAGEKAELESKLKEIMNEVQD 1381
            .:|::|..|::.:...|:.||:..::.| ||:..:|....::.....:|.||.|...|:..:|:.
  Rat  2492 TQEVEAGKQKLEKEEEEVRTLKEQLKGQEQLVCKLARVEGEQQLCQKQKLELRSLTMELEQKVKV 2556

  Fly  1382 VTNRNLFLEQ-------------------KCENFLILEQSNERLKLQNAKLSRQLDE-----TLV 1422
            :.:.|..|:.                   |.|...::|:.| .:..:.|:|.|:|.:     |.:
  Rat  2557 LQSENDALQTTYEALQSSYKSLEGELGLIKMEKMALVERVN-TMTGKEAELQRELHDVEQKSTQL 2620

  Fly  1423 SMQHSEAVPANTE-----FEYLRNIMFQYLTGNTNNETLVKVISAVLKFSPQQAQVALEKEHQRR 1482
            ..::|:.....||     .|.|:|....:|. |.|:                     ||||.||.
  Rat  2621 KEEYSKEKTRLTEDLEVVMEELKNTKVAHLK-NVNH---------------------LEKEFQRA 2663

  Fly  1483 SLLNKLI 1489
            ....||:
  Rat  2664 QGKIKLL 2670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Golgin245	NP_611787.2	Smc	286..1089	CDD:224117	197/974 (20%)
		Phage_GPO	<306..421	CDD:301727	34/165 (21%)
		Smc	737..1442	CDD:224117	176/811 (22%)
		MIT_CorA-like	<1244..>1333	CDD:294313	25/114 (22%)
		Grip	1433..1477	CDD:197860	9/48 (19%)
Cenpf	NP_001094297.1	CENP-F_N	1..302	CDD:287456
		SMC_prok_B	290..1113	CDD:274008	16/65 (25%)
		SMC_prok_B	<829..>1450	CDD:274008	105/452 (23%)
		CENP-F_leu_zip	2116..2255	CDD:287450	34/143 (24%)
		CENP-F_leu_zip	2298..2437	CDD:287450	32/146 (22%)
		V_Alix_like	<2360..2497	CDD:187408	29/143 (20%)
		CENP-F_C_Rb_bdg	<2851..2884	CDD:287463
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000