DRSC/TRiP Functional Genomics Resources

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Protein Alignment Golgin245 and Cenpe

DIOPT Version :9

Sequence 1:NP_611787.2 Gene:Golgin245 / 37702 FlyBaseID:FBgn0034854 Length:1489 Species:Drosophila melanogaster
Sequence 2:NP_776123.3 Gene:Cenpe / 229841 MGIID:1098230 Length:2471 Species:Mus musculus


Alignment Length:1677 Identity:378/1677 - (22%)
Similarity:698/1677 - (41%) Gaps:440/1677 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 TSRTRKLSNSSMASDVSFRLPTYEAPAVYHLQSDLDETSSEFDDSASTARLDVITKDQLYDAYKK 154
            |:|.||.|.:|:..:...:.....|.:.:.:.::..|:.:|.:.|::|..|    .::..::...
Mouse   444 TTRKRKTSVTSLRENSLMKFGESAASSEFEMLNNTLESLAEVEWSSATTLL----SEENVESELN 504

  Fly   155 SLDRYHKYRCRYTDLAKKYKELERDSSKARSVLVETQDKALRRISELREQCTLEQQAKAHLEEAL 219
            ||:      .:|.||...|::|.|::...:..|.|.        :||.|...|||:.:...|   
Mouse   505 SLN------AQYNDLVLDYEQLRRENEDLKLKLKEK--------NELEEFELLEQKEERDQE--- 552

  Fly   220 RVEMDDMSCKMQAYQTKLQLLGE--NPENITAALERSGQQLESEQLIDLEESIGKSPLSTNGSSG 282
                             :||:.|  |.:|:....|...|.||:    ||...:            
Mouse   553 -----------------MQLMHEVSNLKNLIKHAEEYNQDLEN----DLSSKV------------ 584

  Fly   283 VSDLQRLLKERDEQLKSVTEKYEAVRKQEEENVLL------LAQTKQAIHT-------------- 327
                 :||||::||:|::.|..:| :|.|:..:.|      ....|||:.|              
Mouse   585 -----KLLKEKEEQIKNLQEYIDA-QKSEKMKIDLSYTSDATEDLKQAMRTLSDLDTVALDAKKE 643

  Fly   328 -------ELELKDTEVRKLQEKLKQLESQRESHNN--EVKEQF-----KKLQATKQEVDAKLMAT 378
                   .||||: ::.:|.:..||:||..:.:..  |.|::.     |:||...||: :||.|.
Mouse   644 SAFLRSENLELKE-KINELSDSRKQMESDIQMYQRQLEAKKKMQTDLDKELQLAFQEI-SKLSAL 706

  Fly   379 ---EHLLNTL-----------------KESYAIKEQ-----QVVTLEAQLEAIRVENEQKVKDLQ 418
               :.||:.|                 :|...::|:     ::.:|.:::|.:|.|..:|.::|.
Mouse   707 VDGKGLLSNLELEKRITDLQKELNKEAEEKQTLQEEVNLLSELKSLPSEVETLRRELYEKSEELH 771

  Fly   419 KQNEDRNTQASDSSEQLKKLQAAVQD--------AESQLLSKD-----QLLESLRSE----QAAK 466
            ....:|....|:.:.:..::|..:::        |.|||..:.     |.||||.:|    .|..
Mouse   772 IITTEREKLFSEMAHKDSRIQGLLEEIGNTRDDLATSQLSRRGSDGEWQALESLHAELEHRHAGV 836

  Fly   467 EQQLKHLKEQLGKLKQENENY---LD----KLRENKKSSDSQTNEAQDQQKKLQAAKDEAESKLL 524
            .::.:.||:::|.|.:|.|:.   ||    :|....:..:.:|.|.|::..|::|.::|.||:  
Mouse   837 LEERERLKQEIGALSKEAESLAFSLDSVKAELSHKTQELEQKTVEGQERLNKMEALREELESR-- 899

  Fly   525 ATEELLHSLRNDYKAQEEKVALLEDKLKTLSKENDVNVEKLHHINEQREAQSTDSQQKINELRAA 589
              :..|.|:      ::||| ||.:||:...||.....::..::.:.:|:..|:..|..:::   
Mouse   900 --DSSLQSV------EKEKV-LLTEKLQQALKEVKALTQEKKNLKQLQESLQTERDQLRSDI--- 952

  Fly   590 KDEAEAKLLSTEHSLNALQAALSAKEEQAASLEQSLNALKTESEHSLQDLRLH-------NDQLL 647
            :|.....:.:.|..||||:   |.|:.|     :::|.||.::...|.| .||       .|:..
Mouse   953 QDTVNMNIDTQEQLLNALE---SLKQHQ-----ETINMLKMKAAEELSD-NLHVKDRGGARDEAQ 1008

  Fly   648 EIVQR-HQQNDWEAQLARAREELAAIQSQRELHALELEKS-LEMERESVAALNSE-KASQEEQHR 709
            :.:.. .:||:....|....::....:.||::.:|..|.| |:...|||.|...: |...:|...
Mouse  1009 QKMDGIDEQNESAHTLLGGGKDNEVTEEQRKIDSLMQENSGLQQTLESVRAEKEQLKMDLKENIE 1073

  Fly   710 LKLEQLQREIQILQDQHANSESETVAALKGQLEALSQDLATSQASLLAKEKELKASGNKLNKIKK 774
            :.:|. |.|::||:|: ...:.|..|..|......:|:|:.:|..|...|::|:....||.:.::
Mouse  1074 MSIEN-QEELRILRDE-LKRQQEVAAQEKDHATEKTQELSRTQERLAKTEEKLEEKNQKLQETQQ 1136

  Fly   775 QHEQHQAKSSDQSAR---LEALQSELADRLSHSRQVESEKEELQARVTGILEEIGTMQAQMQQVQ 836
            |....|...|...|:   :|:||:|..::.....:||:||.||..|:....||:.::..:...::
Mouse  1137 QLLSTQEAMSKLQAKVIDMESLQNEFRNQGLALERVETEKLELAQRLHESYEEVKSITKERNDLK 1201

  Fly   837 DSHSELEREKRKLES---RIESL------------------------------QQEQVDSSAQDE 868
            :.....|.||::|:.   .||:.                              :.|...:|.||.
Mouse  1202 ELQESFEIEKKQLKEYAREIEAAGLQTKEELNIAHANLKEYQEIITELRGSISENEAQGASTQDT 1266

  Fly   869 RTSA------------------------------------------KLEEIQSENTKLAER---- 887
            ..||                                          .:|.|:.||.:|.::    
Mouse  1267 AKSAPELQGEVPEQELLPVVKEARHSAEKVNGLEPVGAHSRTVHSMTMEGIEIENLRLTKKLEES 1331

  Fly   888 ----NCLLEEQ-------------------------TNHLESQ---------LQAKQDEIGKIQA 914
                :||..|:                         .||||::         |:.::::|..:..
Mouse  1332 QMEISCLTREREDLRRTQETLQVECTQLKEDARRTLANHLETEEELNLARCCLKEQENKIDTLIT 1396

  Fly   915 KLQQVLDEHSKLQNAQELMDHD-HRTLQDKCDAYEKDKLLTKHTLDCLQSASEELHRVK------ 972
            .|.|...|.|.::....|...: .|.:|:.|   ||.:.||:......|....||.:::      
Mouse  1397 SLSQRETELSSVRGQLALTTAELERKVQELC---EKQEELTRKETSEAQGKMSELEQLRELLLAQ 1458

  Fly   973 ------ANLDR-----ELKEQDQQLSELRERQR-----------EQEQQLKDQAERCAKL-KAQN 1014
                  |..||     :|:|..:::..|||.:.           |.|||.:...|..:|| :.||
Mouse  1459 ASALQNAESDRLRLNTQLEESQEEMKTLREEREELRRMQEALHVESEQQKESMKEISSKLQELQN 1523

  Fly  1015 SESETQLQATIS----------NLREQLDAYKQTEQGIQEKLQATNSSYTTQI-ATLEARWSAAN 1068
            .|.|.....||:          :|.:||:|.|.|    .||::..|.:.|.:: .|||...|.|.
Mouse  1524 KEYECLAMKTINETQGSRCEMDHLNQQLEAQKST----LEKVEMENVNLTQRLHETLEEMRSVAK 1584

  Fly  1069 SDVERLHEANDALQLEMEQLKIKHGQEREEVKESIAQKNRQVVELQEAMATRDRQLQEKIEASEK 1133
               ||     |.|....|:|.:    ||:::|:|:.:...:.:|.:|.:......|:|..|...|
Mouse  1585 ---ER-----DELWSMEERLTV----ERDQLKKSLEETVTKGMEKEEELRVAHVHLEEHQETINK 1637

  Fly  1134 LAKF-----DEILIENEYLNKHTKQLEAELAESAELKEKLKSLQCELYVLQEKAEQHAVQMAEKE 1193
            |.|.     |||......| |||..:..  |::.:|:||...|......|:|..:|  ::..:|:
Mouse  1638 LRKMVSDYTDEISHTQGDL-KHTNAVVE--AQNQDLREKEHQLSQVKADLRETVDQ--MEQLKKK 1697

  Fly  1194 TQSATATAEVSELKKAIEEQAVELTRQ----KEHASFVTEQSDAVQ---KDLLQAQQQLHDKQIE 1251
            .::.::|.|..|::|      :|||:|    .:..:.||:::|:::   :.|.:.:.||. |.::
Mouse  1698 LEAQSSTLESREIEK------LELTQQLNENLKKITLVTKENDSLKIMDEALREERDQLR-KSLQ 1755

  Fly  1252 LAMSRDEQALLQAEADGLRQEVICLKEHLSPSTDSDSLRSLNERLQRELEDLKHKSAGAESNMQQ 1316
            ...:||.:     ..:.||...:.||||      .:::..|.|.:..:.|::        |||:.
Mouse  1756 QTEARDLE-----NQEKLRIAHMNLKEH------QETIDRLMETMSEKTEEI--------SNMKM 1801

  Fly  1317 EIEELQANNQQMAERINELET---LRAGIQAQQLLASMAPKNVQEAAAAGEKAELES-----KLK 1373
            |:|.:   |.::.|::.||:|   .|..::|.   ||.|.|.::|......|.|:|:     |:.
Mouse  1802 ELENV---NMKLQEKVQELKTSERQRVKLKAD---ASEAKKELKEQGLTLSKIEMENLNLAQKIH 1860

  Fly  1374 EIMNEVQDVTNRNLFLEQKCENFLILEQSNERLKLQNAKLSRQLDETLVSMQHSEAVPANTEFEY 1438
            |.:.|::.|......| :|.|..|.:|:...:..|:.|.|.       ....|.|.:...     
Mouse  1861 ENLEEMKSVRKERDDL-KKLEEILRMERDQLKDNLREAMLK-------AHQNHEETMKCG----- 1912

  Fly  1439 LRNIMF--QYLTGNTNN-----ETLVKVISAVLKFSPQQAQVALEKEHQRRS 1483
             :.::.  :|.||....     |.|:|..|.:........:|:|:.|.:.::
Mouse  1913 -KGLLCAGEYCTGRLREKCFRIEKLLKRYSEMANDYECLNKVSLDLERETKT 1963

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Golgin245NP_611787.2 Smc 286..1089 CDD:224117 239/1056 (23%)
Phage_GPO <306..421 CDD:301727 38/173 (22%)
Smc 737..1442 CDD:224117 197/885 (22%)
MIT_CorA-like <1244..>1333 CDD:294313 21/88 (24%)
Grip 1433..1477 CDD:197860 9/50 (18%)
CenpeNP_776123.3 KISc 6..336 CDD:214526
KISc_CENP_E 6..329 CDD:276825
SMC_prok_B 586..1436 CDD:274008 195/880 (22%)
DUF972 1041..>1119 CDD:283750 23/79 (29%)
SCP-1 1100..1841 CDD:114219 179/796 (22%)
SbcC 1570..2128 CDD:223496 109/457 (24%)
Kinetochore binding domain. /evidence=ECO:0000250|UniProtKB:Q02224 1959..2249 0/5 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2193..2214
Globular autoinhibitory domain. /evidence=ECO:0000250 2283..2468
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2368..2438
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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