DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Golgin245 and golga4

DIOPT Version :9

Sequence 1:	NP_611787.2	Gene:	Golgin245 / 37702	FlyBaseID:	FBgn0034854	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	XP_017950305.1	Gene:	golga4 / 100495226	XenbaseID:	XB-GENE-5799539	Length:	2123	Species:	Xenopus tropicalis

Alignment Length:	2153	Identity:	468/2153 - (21%)
Similarity:	843/2153 - (39%)	Gaps:	711/2153 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFANLKNKLIEEVKASPSKFQQFANAAQAAVSSSSSTTPNSETNTSNNENFFSITEE-------- 57
            ||..||.|:.||  .||||         :.::......|.| |:|.|.....|:||:
Frog     1 MFKKLKQKISEE--QSPSK---------SPLAPQQQGRPRS-TSTGNRSRTSSVTEQQDDSLATA 53

  Fly    58 ---------------------DTPQNSPYRIQKLPATSASALRGRSTQSLNGATSRTRKLSNSSM 101
                                 :.||:..:::|....:..|..|....:||..::::...|.:||.
Frog    54 DRENGSLSDNINGNDPTSSQRNEPQSFAHKLQMRVPSMESLFRSPIKESLFPSSTKENLLRSSSR 118

  Fly   102 AS--DVSFRLPTYEAPAVYHLQSDLDETSSEFDDSASTARLDVITKDQLYDAYKKSLDRYHKYRC 164
            .|  .:....|:    .|:...||::   ||.:||..:  ::.:.|:||::...:.......||.
Frog   119 DSLNKIDMENPS----TVFDPPSDIE---SEAEDSVGS--IEGLNKEQLFNRLHRMDKSLGNYRG 174

  Fly   165 RYTDLAKKYKELERDSSKARSVLVETQDKALRRISELREQCTLEQQAKAHLEEALRVEMDDMSCK 229
            :|::|...|:.::||..|.:|:|.::||||||||.||||:..::||||.||:|.....:::....
Frog   175 KYSELVTAYRTMQRDKEKLQSILSQSQDKALRRIGELREELQMDQQAKKHLQEEFDASLEEKDQL 239

  Fly   230 MQAYQTKLQLLGENPENITAALE----RSGQQLESE-QLIDLEESIGKSPLSTNGSSGVSDLQ-- 287
            :...||::.||....:|..::.|    .:..:|:|| .|.:::.....:|...|.::.::.||
Frog   240 ISVLQTQVSLLKNRLQNGQSSTELPESTASPELDSESSLQEVDTDNRSTPDDGNAANTLNALQVR 304

  Fly   288 ------------RLLKERDEQLKSVTEKYEAVRKQ------------------------------ 310
                        :.:|...||...::.:.||::.|
Frog   305 VKRQENLLQRCKKSIKSHKEQCAHLSSENEALQNQLDERLQELEKIKELHTSEKSKLITQLRDAK 369

  Fly   311 ------EEENVLLLAQTKQAIHTELELKDTEVRKLQEKLKQLES-------QRES---------- 352
                  |::..:::|:||:.:|..||||:.||.:|:.::|:|.|       |:|.
Frog   370 NSIEQLEQDKGMMIAETKRQMHETLELKEEEVSQLRSRVKKLSSHCEELQQQKEKLEKAAFEDVE 434

  Fly   353 --HNNEVKEQFKKLQATKQEVDAKLMATEHLLNTLKESYAIKEQQVVTLE-------AQLEAIRV 408
              .:.:.::.|:|||..:|....:..:.|..:|..||...:|::.|..::       :::|.:..
Frog   435 KISSQKAEDAFEKLQMEEQIKAIEKASEEERVNLQKELSRVKQEVVDIMKKSCDSRISEIEKVHA 499

  Fly   409 E---------NEQ---KVKDLQ------KQNED----------------------RNTQASDSSE 433
            |         |||   |.::.|      |:|||                      :.|..|.::|
Frog   500 EALLNKEQEYNEQIRLKEQEFQDQMNAVKKNEDETLNLLQDKEKSLMALEELERQKKTIESRAAE 564

  Fly   434 QLKKLQAAVQDAESQLL---------SKDQ----LLESLRSEQAAKEQQLKHL------------ 473
            |||::|..|::...::|         ||.|    |:|:.|:...|:...:|.:
Frog   565 QLKEMQQEVENCRMRILDLESSVAEESKSQDFVSLIETERNNHNAEVATIKEMHKQDLDVLVQDQ 629

  Fly   474 ----KEQLGKLKQENENYLDKLREN-KKSSDSQTNEAQD-------------------QQKKLQA 514
                .|:|..||:||...:.:|:|. ::..||...|.:.                   :|.:|:.
Frog   630 ERIWSEKLELLKKENHTKIIELKEKYQRDYDSHLKEKEHNFQEHIEHMNEKTLEKLDVKQTELET 694

  Fly   515 ----------AKDEAESKLLATEELLHSLRNDYKAQ--------EEKVALL--EDKLKTLSKEND 559
                      |:.|.|.||..||..:..::.:|:||        .|::..:  |.::.|...|.|
Frog   695 LSAELSEAIKARQEIEQKLTDTENEISKIKLEYEAQIKEEREKHSEEIGSIEREKEMHTQGVEKD 759

  Fly   560 V--NVEKLHHINEQREAQSTDSQQKINELRAAKDEAEA------KLLST---EHSLN------AL 607
            :  |:..|..:.:.:|.:..:.:::..:|:.|.::|||      .||..   .|.:|      |.
Frog   760 LKENINNLKLLQDSKECELEEFRKENQKLKEAAEKAEADHKEAFALLEAARHSHEINTHEKEQAY 824

  Fly   608 QAALSAKEEQAASLEQSLNALK--TE-SEHSLQDLRLHNDQLLEIVQR-----HQQN-------- 656
            :..|...:|....:.|..|.||  || :|..|:::::..|.....||.     |:::
Frog   825 ELKLKELQEMLKGMTQERNDLKEVTEKAETQLKNMQIELDSNKAQVQSLTKQIHEESMNMADKLN 889

  Fly   657 ----DWEAQ---LARAREELAAIQSQRELHALELEKSLEMERESVAALN---SEK----ASQEEQ 707
                :.|.|   |....||::.|.|:|| |  ||:|..|...:.:..||   |||    .|.:|.
Frog   890 TLVLESETQVKGLKEQIEEISRIASERE-H--ELKKVKEDHIQIILDLNNTISEKEKNILSLQED 951

  Fly   708 HRL-------KLEQLQREIQILQDQHANSESETVAALKGQLEALSQDLATSQASLLAKEKEL-KA 764
            :::       |:|:|:::.:.||:......||..:.||.::|....:|...:.....|..|: :|
Frog   952 YKVKHKNLDAKMEKLKQKFKELQESSKKKYSELESKLKKEIEKKQNELINKEREFNEKIHEMAQA 1016

  Fly   765 SGNKLN------------KIKKQHEQHQAKSSDQSARLEALQSELADRLSHSRQVESEKEELQAR 817
            |...:|            :|:...:.||.:..:.:...|...|:||:.|.     |..:||||.:
Frog  1017 SSTGINHAMAQLELNHKEQIQNMTDNHQRELQETTEACEKKLSQLAEDLR-----EKHEEELQEK 1076

  Fly   818 VTGILEEIGTMQAQMQQVQDSHSELE--RE-KRKLESRIESLQQEQVDSSAQDERTSAKLEEIQS 879
            ...|.|.......:.::.:|:..|:.  || |.::::....||::...|:||....:....|.::
Frog  1077 DQVIAESRKQFNIKNKEKEDADKEISDLRELKTQMDATFNDLQEQLCQSAAQVLHLTQSENEFKT 1141

  Fly   880 ENTKLAERNCLLEEQTNHLE---SQLQAKQDEI-GKI---QAKLQQVLDEHSKL----------- 926
            ..|:|.....:|::|.:.|:   .:.::|.||| .|:   :.|.|.:...|:|:
Frog  1142 NCTRLTTEKQILQQQLDELKILAEEDKSKNDEIVNKVRLAEEKYQDLETLHNKVRADFAKELQDK 1206

  Fly   927 -----------------------QNAQELMD---------HDHR--------------------- 938
                                   :||::|.:         |.::
Frog  1207 LVEKENEFKHLLVKQENQLILCCKNAEDLFETLANGLTENHKYKLNGLIVKIANLESCMHKLKEV 1271

  Fly   939 TLQDKCDAYEKDKLLTKHTLD------CLQSASEELHRVKANLDRELKEQDQQLSELRERQREQE 997
            ||:.:...||::|.|.:.:.:      .|..|::|......:|..|::..:.| :|:.:::...:
Frog  1272 TLKQRSRIYEQEKQLEQFSNELLSVNQSLNQATQEKEFATLSLKNEIEALNFQ-NEMLKKEGGSQ 1335

  Fly   998 QQLKDQAERC-AKLKAQNS----------------ESE-TQLQATISNL------------REQL 1032
            ||:.|:.|.| .:||.:.|                ||| :.|.|.|:.|            :|..
Frog  1336 QQVADEKESCITQLKKELSENINIVTSLTEVVKQKESEVSSLSALINELKLKHENCVDLTEKENA 1400

  Fly  1033 DAY-----KQTEQGIQEKLQATNSSYTTQIATLEARWSAANSDVERLHEANDALQLEMEQLKIKH 1092
            .|:     ||::|.:|.::|    ....:|..|....||...:..:|....|..:.:.|...:::
Frog  1401 IAFLTAQQKQSQQELQNQIQ----DLMAKIEVLNKEKSAQIDEAAKLKNKLDEWKKKAELKFVQN 1461

  Fly  1093 GQEREEVKESIAQKNRQVVELQEAMAT---------------------RDRQLQEKIEA------ 1130
            ....:|:||.:...|:|:||..|.:.|                     ::.:|..::|.
Frog  1462 HNTIKELKEKVESVNKQIVEKDEKLRTVTEEFECHRSNIQETQLMSESKEFELTTQLEGQKSKIS 1526

  Fly  1131 ----------SEKLAKFDEILIENEYLNKHTKQLEAELA--------ESAELKEKLKSLQCELYV 1177
                      |||.:..|:|.|:....::..|.|..:|.        .|.|::.|:.:|:.|:..
Frog  1527 ELEDQCSKLMSEKKSLMDQIEIQTIQQSEDKKALVEQLQHIQYASDNNSKEVQNKVITLEKEIDA 1591

  Fly  1178 LQEK--AEQ--------HAVQMAEKETQ------SATATAEVSELKKAIEEQAVELTRQ------ 1220
            |:||  |||        ...|:.:||.:      :|.:|.::|||||..|::...|.:|
Frog  1592 LKEKLDAEQTKWQLEKAECFQLKDKELKILEEKLTAESTNKLSELKKKAEQKIASLKKQLMSQID 1656

  Fly  1221 -KEHASFVTE------------QSDAVQ------------------------------------- 1235
             ||.:....|            :|..||
Frog  1657 EKEQSRKALESQLNVLKDNMQKESQEVQEGLQQKVENQDKKYALLLEQKKNTEADLANIRSELKL 1721

  Fly  1236 --------KDLLQAQQQLHDKQIELAMSRDEQALLQ----------------------------- 1263
                    :|:|:..||.|.:: ||..|..|||||:
Frog  1722 KELRVKEMEDILKDVQQKHSER-ELTDSEKEQALLKELESQMLTNNQLVSTHEKALRALQDDLNV 1785

  Fly  1264 --AEADGLRQEV-----------ICLKEHLSPST---------DSDSLRSLNE--RLQRELEDL- 1303
              ||....::|:           :..:|..|..:         :|:.|:..||  :||:::..|
Frog  1786 KDAEIKTFKEEIDEKSKSLNELQVLFEETQSQESAMRIKLEEMESEKLKFKNEITKLQKDMRSLR 1850

  Fly  1304 -----------KHKSAGAESNM--QQEIEELQAN----------NQQMAERINELET-------- 1337
                       |..:..||..:  :||..||:.|          |.|||::..|:||
Frog  1851 KEHSQELDLLKKEITEEAEQRIKYEQEDSELKHNSKLKQLMREFNTQMAQKEREVETAVQETIAK 1915

  Fly  1338 --------LRA-GIQAQQLLASMAPK---------------NVQEAAAAGEKAELESKL------ 1372
                    :|: .|:|..|...:|.|               ..:|.....:..||:.:|
Frog  1916 AQEVEAELMRSQQIEAVHLHKKIAEKEDDLKRTVKRYEELLEAREEEMTAKVTELQEQLERLQEQ 1980

  Fly  1373 ---KEIMNE----VQDVTNRNLFLEQKCENFLILEQSNE-RLKLQNAK-----LSRQLDETL--- 1421
               ||:.||    |::.|:..:|..|..:.   ..|.|| :||.|..|     |..|:....
Frog  1981 LTQKEMQNEEEENVEEATSPEVFQAQLAQK---TSQVNEYKLKEQELKEKVHILEDQVKNFTRGV 2042

  Fly  1422 -----------VSMQHS--EAVPANTEFEYLRNIMFQYLTGNTNNETLVKVISAVLKFSPQQAQV 1473
                       |:.||:  ......|||||||.:||:|:.|. ..:|:.|||:.||:|...|||.
Frog  2043 FYTPIGTPYKEVNNQHAGVSVFGEPTEFEYLRKVMFEYMMGR-ETKTMAKVITTVLRFPTDQAQQ 2106

  Fly  1474 ALEKEHQR 1481
            .|::|..|
Frog  2107 ILQREETR 2114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Golgin245	NP_611787.2	Smc	286..1089	CDD:224117	242/1169 (21%)
		Phage_GPO	<306..421	CDD:301727	38/194 (20%)
		Smc	737..1442	CDD:224117	222/1101 (20%)
		MIT_CorA-like	<1244..>1333	CDD:294313	34/165 (21%)
		Grip	1433..1477	CDD:197860	22/43 (51%)
golga4	XP_017950305.1	mukB	<207..>428	CDD:235316	50/220 (23%)
		Smc	328..1113	CDD:224117	171/792 (22%)
		SMC_prok_B	778..1592	CDD:274008	172/826 (21%)
		SMC_prok_B	<1277..1985	CDD:274008	140/713 (20%)
		GRIP	2067..2110	CDD:383285	22/43 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2048
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3111
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007308
OrthoInspector	1	1.000	-	-		oto105049
Panther	1	1.100	-	-	LDO	PTHR19327
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.150