DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-V and nphs1

DIOPT Version :9

Sequence 1:	NP_611765.2	Gene:	side-V / 37679	FlyBaseID:	FBgn0085400	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_001035777.1	Gene:	nphs1 / 692352	ZFINID:	ZDB-GENE-051102-1	Length:	1242	Species:	Danio rerio

Alignment Length:	1246	Identity:	254/1246 - (20%)
Similarity:	427/1246 - (34%)	Gaps:	392/1246 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VQGEQHPATA---DEGPLSEILTAVGSEVALPCDLVPGTGIVDKVQLVIWYRQGNVKPIYTFDAR 88
            |:|||:..|.   |..|.:||......|..|..:....:|..||:|        |.....|..||
Zfish   144 VEGEQYTVTCIAPDAKPPAEITIFRDGEELLESESYTMSGSQDKLQ--------NTHAEVTIRAR 200

  Fly    89 G---------RPLNLGIPWADESVFNKKAHFHHDTDPPALRIKNIQTSD--AGLY---KCRVDFH 139
            .         |..|...|.|.|:....|.:|    .|.|..|..::..:  ||.:   .| :.:.
Zfish   201 SSDDTRRLTCRAKNPASPRALETGMTMKVYF----PPQAPMIMGLENEEVKAGSFLKVVC-MSYG 260

  Fly   140 KSP--TRNWRINVTVL--------VPPTALTIL-------DHHGA----EIRDQTAGPY------ 177
            .:|  |.:|..|..||        |...|.::|       |:|..    .|...|..|.
Zfish   261 GNPLATLHWTKNGEVLSTSWDVDFVSRRASSVLKMEVKPEDNHAVLQCQSINQVTRSPMSLTRTL 325

  Fly   178 -----------------LEGDSIDLTCLSSGGVPPPRVSWW---REHALIDDSFQVLPDGSVRNV 222
                             :||:.|:|:|.:|...||..:.||   :|....:.:|....:|.:..|
Zfish   326 TVPFEPAEVTLLGSFEAVEGEEINLSCSTSSSNPPVHIRWWLGFKELNRTEVTFAEGDNGGMMTV 390

  Fly   223 LRLKN-IQRKDLLTMYTCQASNGH-----------VVPALTKKVILDMNLPPLSLLLQGLNHAVI 275
            ..|.: :.|:|......|:|.|..           :|....:||.||  .||.::.|.
Zfish   391 SNLTHKVSREDNGLSLQCEAFNKGTRFSSVRAAELIVYYPPQKVWLD--APPPNVFLH------- 446

  Fly   276 AGTRSHVTCTAIGARPPPEIIWSKAGQIVRGATSSTSSDGNTTISELMLIPVPEDNERQVVC--- 337
            :|:...:.|.:.|..|..::.|.|..::|..|:...||:...: .||:|...|.||.....|
Zfish   447 SGSTLRLVCFSSGGNPTGQLTWLKNNKVVLTASKQVSSERGVS-RELLLTLHPSDNLATYRCDSS 510

  Fly   338 ------------------SISLNAGITSQQLHEGHTTVMTTLGNGHTGLYLKDSRVLNVTHA--P 382
                              ::|:......::|..|.|..:..|..       ..:...|::.:  |
Zfish   511 NKAKKVLSAQTKFRVLFPAVSVKIVAKQKELRRGQTLDLDCLAG-------SSNPTANISWSLGP 568

  Fly   383 IV------------------NLNLGAPLDPDN-------------LLKGTDVYLECD-------- 408
            ::                  ...|...|:|.:             |.:|.:.:...|
Zfish   569 VILKGVDQAPKRAEFGGMSRTSKLSLTLEPHHWRKRITCQAFSNVLSEGVNNFYSLDVLFPPEFS 633

  Fly   409 --------------------VKANPAITRVEWYHSDKQLHSSRG--IIISNQTLVLQGISKSSHG 451
                                |.|||.....||....::|...|.  ...|:.||.:..:|:...|
Zfish   634 AEQPDEVQVIEDETATLPAKVSANPDEITCEWIFQGEKLVKERDPRYTFSDWTLEIVNVSRRDGG 698

  Fly   452 QYFCRASNLQGSVSSNEVYLDVKYPPVCKSESTIIRAALKQTINITCEVDANPVDNLNYKWHFNN 516
            .|....||.:|| :..::.|||:|.|..:.:|..:...:..|.::.|..||||:.:..:.|.:
Zfish   699 DYIIECSNAEGS-NRTKLRLDVQYSPTVRMKSDPVFVNIGDTADLLCVADANPITSSMFSWKW-- 760

  Fly   517 SLESLIELPQLGQGAPVMLASGSDQSGYYQRSKRKHSHGMQQRLLHGRHGRMAAVRFEDEDEDGY 581
                      :|:|.       .|:.|                              |:.::||.
Zfish   761 ----------MGEGE-------RDELG------------------------------EESEDDGT 778

  Fly   582 GE---FEEYGDEVGQPFTQMVYSNMVHKNHVESSKQQQRKQLSPQQQQ--QQQQMAS-GGSSGDS 640
            |.   :|...|..|  ..|....|.:  :...|.:.|...:.:|..|:  |.:::|| |..|.|:
Zfish   779 GVLTIYEVTRDRAG--VYQCTADNGI--SPTGSVEGQLIVRFAPDLQKGPQWRKVASRGDGSNDA 839

  Fly   641 HTPSGGVILERKRLVALHKQHHRGGVATPPTTTAAPPLNNVYSYHVESYESFGAI---------- 695
            :     |:.:.:.:..:..:..:.|.          ||:.....:.|:.||.|.|
Zfish   840 N-----VVCQAQGVPRVQFRWAKNGF----------PLDLGNPRYEETTESTGTIHTSILTVINV 889

  Fly   696 ---------SCVASSPMGHSAPCWYHIQ--PADLPEPVKNCTAYNATANSLQIQCIPGYDGGIPQ 749
                     :|.|.:.||..:   ..||  ..:.|:|..:.........|:.::.:||:|||:.|
Zfish   890 SAALDYAIFTCTAHNSMGEDS---LDIQLLSTNHPDPPSDLKLLRVDQTSVTLEWMPGFDGGLTQ 951

  Fly   750 HFHAQIYDELNRQILYNASYKYSE--------FTVKRLPSDSVFVIRITAVNAQGASKVAYRLRG 806
            .|..:.      |...:|||.|.:        :||..|...:::...:.|:|:.|.|..|...:.
Zfish   952 IFRVRY------QWAGSASYMYVDVFPPTATVYTVTGLNPSTMYNFSVNALNSIGESSYADNNKI 1010

  Fly   807 RTLSAPLLRTAS---STAVLVQLTPLLGALVGVIATLILVAICVVIVIK----FRSKRGGRRHGS 864
            .|::....:.|.   |||  .|.:.|.|..:.|...:|||...|:.::.    |...|..||...
Zfish  1011 LTVTTADAKEADGGVSTA--DQDSALAGGGLPVYVVVILVVGGVLFLLNPFICFLLARWKRRRSL 1073

  Fly   865 GADATTTEADKGSAEPLSRNMGSHSSLEDKNPDVVPQEANSEDEFHQEEKAFDRLNMESQRILYT 929
                      ||:...:|:...|    |::.     ..|:|...:...|    .:|..:||.|.
Zfish  1074 ----------KGNTSSISQETKS----EEQR-----STASSSTRYASRE----LINASAQRTLL- 1114

  Fly   930 PPTRINTASPPPPSLSPTFGKQYGELSLTTNPAFSLYNTPQRAPAVQ------------------ 976
                ::::|.|..|:..::|:|       .||.: .|.|...:||:.
Zfish  1115 ----VDSSSEPDSSVYESYGRQ-------ENPHY-YYPTEAYSPALYAHPEGPEDCDGRHGTSPF 1167

  Fly   977 -------RPVY---TAPPPLLSTRTPP--NIYTRIP------GRGGGGGGATVTAAGAGGYHLPA 1023
                   |.:|   .|..||     ||  :|:.:.|      ||........||   .|.|....
Zfish  1168 THVYEEVRGMYEDLQACSPL-----PPAAHIHPQAPFSTYYEGRAYSKADVDVT---IGAYDSMV 1224

  Fly  1024 YETRTSPTSPY 1034
            |..|.....|:
Zfish  1225 YRRRRDTDLPF 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-V	NP_611765.2	Ig	42..153	CDD:299845	29/126 (23%)
		IG_like	42..152	CDD:214653	29/125 (23%)
		IGc2	179..245	CDD:197706	20/69 (29%)
		IG_like	179..245	CDD:214653	20/69 (29%)
		Ig	<282..348	CDD:299845	17/86 (20%)
		IGc2	400..459	CDD:197706	16/88 (18%)
		FN3	719..798	CDD:214495	21/86 (24%)
nphs1	NP_001035777.1	IG_like	33..126	CDD:214653
		Ig	133..216	CDD:386229	21/79 (27%)
		Ig	261..313	CDD:386229	12/51 (24%)
		Ig	333..419	CDD:386229	20/85 (24%)
		ig	439..511	CDD:365836	20/79 (25%)
		IG_like	637..719	CDD:214653	19/82 (23%)
		Ig_3	723..800	CDD:372822	21/127 (17%)
		Ig_hNephrin_like	814..922	CDD:143250	23/125 (18%)
		FN3	921..1012	CDD:238020	23/96 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810