Protein Alignment side-V and nphs1

DIOPT Version :10

• Sequence 1: NP_611765.2
• Gene: side-V / 37679
• FlyBaseID: FBgn0085400
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: XP_073779348.1
• Gene: nphs1 / 692352
• ZFINID: ZDB-GENE-051102-1
• Length: 1287
• Species: Danio rerio
• Alignment Length: 1290
• Identity: 268/1290 - (20%)
• Similarity: 437/1290 - (33%)
• Gaps: 405/1290 - (31%)

  Fly    27 VQGEQHPATA---DEGPLSEILTAVGSEVALPCDLVPGTGIVDKVQLVIWYRQGNVKPIYTFDAR 88
            |:|||:..|.   |..|.:||......|..|..:....:|..||:|        |.....|..||
Zfish   189 VEGEQYTVTCIAPDAKPPAEITMFRDGEELLESESYTMSGSQDKLQ--------NTHAEVTIRAR 245

  Fly    89 G---------RPLNLGIPWADESVFNKKAHFHHDTDPPALRIKNIQTSD--AGLY---KCRVDFH 139
            .         |..|...|.|.|:....|.:|    .|.|..|..::..:  ||.:   .| :.:.
Zfish   246 SSDDTRRLTCRAKNPASPRALETGMTMKVYF----PPQAPMIMGLENEEVKAGSFLKVVC-MSYG 305

  Fly   140 KSP--TRNWRINVTVL--------VPPTALTIL-------DHHGA----EIRDQTAGPY------ 177
            .:|  |.:|..|..||        |...|.::|       |:|..    .|...|..|.
Zfish   306 GNPLATLHWTKNGEVLSTSWDVDFVSRRASSVLKMEVKPEDNHAVLQCQSINQVTRSPMSLTRTL 370

  Fly   178 -----------------LEGDSIDLTCLSSGGVPPPRVSWW---REHALIDDSFQVLPDGSVRNV 222
                             :||:.|:|:|.:|...||..:.||   :|....:.:|....:|.:..|
Zfish   371 TVLFEPAEVTLLGSFEAVEGEEINLSCSTSSSNPPVHIRWWLGFKELNRTEVTFAEGDNGGMMTV 435

  Fly   223 LRLKN-IQRKDLLTMYTCQASNGH-----------VVPALTKKVILDMNLPPLSLLLQGLNHAVI 275
            ..|.: :.|:|......|:|.|..           :|....:||.||  .||.::.|.
Zfish   436 SNLTHKVSREDNGLSLQCEAFNKGTRFSSVRAAELIVYYPPQKVWLD--APPPNVFLH------- 491

  Fly   276 AGTRSHVTCTAIGARPPPEIIWSKAGQIVRGATSSTSSDGNTTISELMLIPVPEDNERQVVC--- 337
            :|:...:.|.:.|..|..::.|.|..::|..|:...||:...: .||:||..|.||.....|
Zfish   492 SGSTLRLVCFSSGGNPTGQLTWLKNNKVVLTASKQVSSERGVS-RELLLILHPSDNLATYRCDSS 555

  Fly   338 ------------------SISLNAGITSQQLHEGHT----------------------------- 355
                              ::|:......::|..|.|
Zfish   556 NKAKKVLSTQTKFRVLFPAVSVKIVAKQKELRRGQTLDLDCLAGSSNPTANISWSLGPVILKGVD 620

  Fly   356 ---------------TVMTTLGNGHTGLYLKDSRVLNVTHAPIVN---LNLGAPLD-----PD-- 395
                           .:..||.:.|....:......||....:.|   |::..|.:     ||
Zfish   621 QAPKRAEFGGMSRTSKLSLTLESHHWRKRITCQAFSNVLSEGVNNFYSLDVLFPPEFSDEQPDEV 685

  Fly   396 NLLKGTDVYLECDVKANPAITRVEWYHSDKQLHSSRG--IIISNQTLVLQGISKSSHGQYFCRAS 458
            .:::.....|...|.|||.....||....::|...|.  ...|:.||.:..:|:...|.|....|
Zfish   686 QVIEDETATLPAKVSANPDEITCEWIFQGEKLVKERDPRYTFSDWTLEIVNVSRRDGGDYIIECS 750

  Fly   459 NLQGSVSSNEVYLDVKYPPVCKSESTIIRAALKQTINITCEVDANPVDNLNYKWHFNNSLESLIE 523
            |.:|| :..::.|||:|.|..:.:|..:...:..|.::.|..||||:.:..:.|.:
Zfish   751 NAEGS-NRTKLRLDVQYSPTVRMKSDPVFVNIGDTADLLCVADANPITSSMFSWKW--------- 805

  Fly   524 LPQLGQGAPVMLASGSDQSGYYQRSKRKHSHGMQQRLLHGRHGRMAAVRFEDEDEDGYGE---FE 585
               :|:|.       .|:.|                              |:.::||.|.   :|
Zfish   806 ---MGEGE-------RDELG------------------------------EESEDDGTGVLTIYE 830

  Fly   586 EYGDEVGQPFTQMVYSNMVHKNHVESSKQQQRKQLSPQQQQ--QQQQMAS-GGSSGDSHTPSGGV 647
            ...|..|  ..|....|.:  :...|.:.|...:.:|..|:  |.:::|| |..|.|::     |
Zfish   831 VTRDRAG--VYQCTADNGI--SPTGSVEGQLIVRFAPDLQKGPQWRKVASRGDGSNDAN-----V 886

  Fly   648 ILERKRLVALHKQHHRGGVATPPTTTAAPPLNNVYSYHVESYESFGAI----------------- 695
            :.:.:.:..:..:..:.|.          ||:.....:.|:.||.|.|
Zfish   887 VCQAQGVPRVQFRWAKNGF----------PLDLGNPRYEETTESTGTIHTSILTVINVSAALDYA 941

  Fly   696 --SCVASSPMGHSAPCWYHIQ--PADLPEPVKNCTAYNATANSLQIQCIPGYDGGIPQHFHAQIY 756
              :|.|.:.||..:   ..||  ..:.|:|..:.........|:.::.:||:|||:.|.|..:.
Zfish   942 IFTCTAHNSMGEDS---LDIQLLSTNHPDPPSDLKLLRVDQTSVTLEWMPGFDGGLTQIFRVRY- 1002

  Fly   757 DELNRQILYNASYKYSE--------FTVKRLPSDSVFVIRITAVNAQGASKVAYR---LRGRTLS 810
                 |...:|||.|.:        :||..|...:::...:.|:|:.|.|..|..   |...|..
Zfish  1003 -----QWAGSASYMYVDVFPPTATVYTVTGLNPSTMYNFSVNALNSIGESSYADNNKILMVTTAD 1062

  Fly   811 APLLRTASSTAVLVQLTPLLGALVGVIATLILVAICVVIVIK----FRSKRGGRRHGSGADATTT 871
            |.......|||  .|.:.|.|..:.|...:|||...|:.::.    |...|..||.....|.::.
Zfish  1063 AKEADGGVSTA--DQDSALAGGGLPVYVVVILVVGGVLFLLNPFICFLLARWKRRRSLKGDTSSI 1125

  Fly   872 EADKGSAEPLSRNMGSHSSLEDKNPDVVPQEANSEDEFHQEEKAFDRLNMESQRILYTPPTRINT 936
            ..:..|.|..|                   .|:|...:...|    .:|..:||.|.     :::
Zfish  1126 SQETKSEEQRS-------------------TASSSTRYASRE----LINASAQRTLL-----VDS 1162

  Fly   937 ASPPPPSLSPTFGKQYGELSLTTNPAFSLYNTPQRAPAVQRPVYTAPPPLLSTRTPPNIYTRIPG 1001
            :|.|..|:..::|:|       .||.: .|.|...:||    :|..|       ..|..|   .|
Zfish  1163 SSEPDSSVYESYGRQ-------ENPHY-YYPTEAYSPA----LYAHP-------EGPEDY---DG 1205

  Fly  1002 RGGGGGGATVTAAGAGGYHLPAYETRTSPTSPYGSTTTCTMPLLGGQSNGSLQSGGVGGVGGLVG 1066
            |.|                          |||:    |.....:.|... .||
Zfish  1206 RHG--------------------------TSPF----THVYEEVRGMYE-DLQ------------ 1227

  Fly  1067 GGACNTLPHPGSLHVGGISAALTSSVTSG--------NITIGAAQSLLTSPRSQT 1113
              ||:.||....:|    ..|..|:...|        ::||||..|::...|..|
Zfish  1228 --ACSPLPPAAHIH----PQAPFSTYYEGRAYSKADVDVTIGAYDSMVYRRRRDT 1276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
side-V	NP_611765.2	V-set	42..153	CDD:462230	29/126 (23%)
		Ig_3	178..243	CDD:464046	19/68 (28%)
		Ig	274..359	CDD:472250	22/149 (15%)
		Ig strand B	280..284	CDD:409353	0/3 (0%)
		Ig strand C	294..298	CDD:409353	0/3 (0%)
		Ig strand E	320..324	CDD:409353	2/3 (67%)
		Ig strand F	334..345	CDD:409353	2/31 (6%)
		Ig strand G	355..358	CDD:409353	1/46 (2%)
		Ig	400..466	CDD:472250	19/67 (28%)
		Ig strand B	403..407	CDD:409353	1/3 (33%)
		Ig strand C	416..421	CDD:409353	1/4 (25%)
		Ig strand E	438..442	CDD:409353	2/3 (67%)
		Ig strand F	452..457	CDD:409353	1/4 (25%)
		Ig strand G	465..468	CDD:409353	0/2 (0%)
		FN3	719..798	CDD:214495	21/86 (24%)
nphs1	XP_073779348.1	None