DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-V and Nphs1

DIOPT Version :9

Sequence 1:	NP_611765.2	Gene:	side-V / 37679	FlyBaseID:	FBgn0085400	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_072150.1	Gene:	Nphs1 / 64563	RGDID:	620460	Length:	1252	Species:	Rattus norvegicus

Alignment Length:	1137	Identity:	227/1137 - (19%)
Similarity:	392/1137 - (34%)	Gaps:	335/1137 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRQPVAFV----LVLATALSLVQGEQH------------PATADEGPLSEILTAVGSEVALPCDL 58
            |...:.|:    .:|..:.::.:|.:.            |.::|.|   ::|...||..||...:
  Rat   181 PAPDITFIQSGRTILDVSSNVNEGSEEKLCITEAEARVIPQSSDNG---QLLVCEGSNPALDTPI 242

  Fly    59 ----------VPGTGIVD-------------KVQLVIWYRQGNVKPIYTFDARGRPLNLGIPWAD 100
                      .||..::|             .::|....|.||......:...|:|::..  |..
  Rat   243 KASFTMNILFPPGPPVIDWPGLNEGHVRAGENLELPCTARGGNPPATLQWLKNGKPVSTA--WGT 305

  Fly   101 ESVFNKKAHFHHDTDPPALRIKNIQTSDAGL-YKCR-VDFHKSPTRNWRINVTVLVPPTALTILD 163
            |         |......::.:..::..|.|. ..|: .:...:.|:...|.:.|..||:|:|||
  Rat   306 E---------HAQAVAHSVLVMTVRPEDHGARLSCQSYNSVSAGTQERSITLQVTFPPSAITIL- 360

  Fly   164 HHGAEIRDQTAGPYLEGDSIDLTCLSSGGVPPPRVSWWREHALIDDSFQVLPDG------SVRNV 222
              |:..:.       |..::.|.||:....|...:.||.....:..:.:.:.||      |:.|:
  Rat   361 --GSVSQS-------ENKNVTLCCLTKSSRPRVLLRWWLGGRQLLPTDETVMDGLHGGHISMSNL 416

  Fly   223 LRLKNIQRKDLLTMYTCQA-SNGHVVPALTKKVILDMNLPPLSLLLQG--LNHAVIAGTRSHVTC 284
            ..|  ::|:|.....||:| |:........|.:.|::..|...|.::|  ....:..|||..:.|
  Rat   417 TFL--VRREDNGLPLTCEAFSDAFSKETFKKSLTLNVKYPAQKLWIEGPPEGQYIRTGTRVRLVC 479

  Fly   285 TAIGARPPPEIIWSKAGQIV----------RGATSSTSSDGNTTISELMLIPVPEDNERQVVCSI 339
            .|||..|.|.:||.|..:.|          |....|....|:|...||:||..|.||..:..|..
  Rat   480 LAIGGNPDPSLIWFKDSRPVSEPRQPQEPRRVQLGSVEKSGSTFSRELVLIIGPPDNRAKFSCKA 544

  Fly   340 -SLNAGITSQQLHEGHTTVMTTLGNGHTGLYLKDSRVLNVT-----HAPIVNLN----------- 387
             .|:|  ::|.:.:...|.:|.|.|...   |:....||:|     ..|.|||:
  Rat   545 GQLSA--STQLVVQFPPTNLTILANSSA---LRPGDALNLTCVSISSNPPVNLSWDKEGERLEDV 604

  Fly   388 ----------------------------------------------------------LGAPLDP 394
                                                                      ||..:..
  Rat   605 AAKPQSAPFKGSAASRSVFLRVSSRDHGQRVTCRAHSEALRETVSSFYRFNVLYPPEFLGEQVRA 669

  Fly   395 DNLLKGTDVYLECDVKANPAITRVEWYHSDKQLHSSRG---IIISNQTLVLQGISKSSHGQYFCR 456
            ..:::...|.|...|.||||.....|.....:|..:.|   .|:|...|.|..::::..|.|...
  Rat   670 VTVVEQGQVLLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSGGALQLWNVTRADDGFYQLH 734

  Fly   457 ASNLQGSVSSNEVYLDVKYPPVCKSESTIIRAALKQTINITCEVDANPVDNLNYKWHFNNSLESL 521
            ..|.:|:..: .:.|||.|.|..::........:..:::|.|.|||||:....:.|......|..
  Rat   735 CQNSEGTAEA-LLKLDVHYAPTIRALRDPTEVNVGGSVDIVCTVDANPILPEMFSWERLGEEEED 798

  Fly   522 IELPQLGQGAPVMLASGSDQSGYYQRSKRKHSHGMQQRLLHGRHGRMAAVRFEDEDEDGYGEFEE 586
            :.|..:                              :::..|..||:   |.........|.::.
  Rat   799 LNLDDM------------------------------EKVSKGSTGRL---RIRQAKLSQAGAYQC 830

  Fly   587 YGDEVGQPFTQMVYSNMVHKNHVESSKQQQRKQLSPQQQQQQ--QQMASGGSSGDSHT------- 642
            ..|....|..:.:...:|              :.:||..|..  .::|:.|.|..|.|
  Rat   831 IVDNGVAPAARGLVRLVV--------------RFAPQVDQPTPLTKVAAAGDSTSSATLHCRARG 881

  Fly   643 --------PSGGVILERKRLVALHKQHHRGGVATPPTTTAAPPLNNVYSYHVESYESFGAISCVA 699
                    ...||.|:.:.......::|:|.|.:...|.|          :|.:.:.:....|.|
  Rat   882 VPNIDFTWTKNGVPLDLQDPRYTEHRYHQGVVHSSLLTIA----------NVSAAQDYALFKCTA 936

  Fly   700 SSPMG--HSAPCWYHIQPADL--PEPVKNCTAYNATANSLQIQCIPGYDGGIPQHFHAQIYDELN 760
            ::.:|  |:     :||...:  |:|.......:.:.:|:.::..||:|||:||.|
  Rat   937 TNALGSDHT-----NIQLVSISRPDPPLGLKVVSISPHSVGLEWKPGFDGGLPQRF--------- 987

  Fly   761 RQILYNA------------SYKYSEFTVKRLPSDSVFVIRITAVNAQGASKVAYRLRGRTLSAP- 812
             ||.|.|            ..:.:.||:..|...:.:.|.:.|.||.|.|.:..:....:::.|
  Rat   988 -QIRYEALETPGFLHVDVLPTQATTFTLTGLKPSTRYRIWLLASNALGDSGLTDKGIQVSVTTPG 1051

  Fly   813 -----------LLRTASSTAVLVQLTPLLGALVGVIATLILVAICVVIVIKFRSKRGG----RRH 862
                       |..........:.|.|:|.|:.|::  |:..|.||          ||    ||.
  Rat  1052 PDQAPEDTDHQLPTELPPGPPRLPLLPVLFAVGGLL--LLSNASCV----------GGLLWRRRL 1104

  Fly   863 GSGADATTTEADKGSAEPLSRNMGSHS-----------------------SLEDKNPDVVPQEAN 904
            ...|:..:.:.:.||.:.: ||....|                       |:.|.:|.:.|  ..
  Rat  1105 RRLAEEISEKTEAGSEDRI-RNEYEESQWTGDRDTRSSTVSTAEVDPNYYSMRDFSPQLPP--TL 1166

  Fly   905 SEDEFHQ----EEKAF-DRLNMESQRILYTPP 931
            .|..:||    |:.|| ..|:.|.:| .|.||
  Rat  1167 EEVLYHQGAEGEDMAFPGHLHDEVER-AYGPP 1197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-V	NP_611765.2	Ig	42..153	CDD:299845	22/135 (16%)
		IG_like	42..152	CDD:214653	22/134 (16%)
		IGc2	179..245	CDD:197706	18/72 (25%)
		IG_like	179..245	CDD:214653	18/72 (25%)
		Ig	<282..348	CDD:299845	24/76 (32%)
		IGc2	400..459	CDD:197706	16/61 (26%)
		FN3	719..798	CDD:214495	23/90 (26%)
Nphs1	NP_072150.1	Ig	52..128	CDD:299845
		IG_like	52..127	CDD:214653
		C2-set_2	155..242	CDD:285423	12/63 (19%)
		Ig_3	256..335	CDD:290638	13/89 (15%)
		IG_like	268..350	CDD:214653	14/92 (15%)
		C2-set_2	358..440	CDD:285423	22/93 (24%)
		I-set	460..555	CDD:254352	29/96 (30%)
		Ig	472..555	CDD:299845	28/84 (33%)
		Ig	563..646	CDD:299845	11/85 (13%)
		IG_like	670..750	CDD:214653	19/80 (24%)
		Ig	676..750	CDD:299845	19/74 (26%)
		Ig_3	753..834	CDD:290638	16/113 (14%)
		IG_like	762..848	CDD:214653	17/118 (14%)
		Ig	848..956	CDD:299845	24/136 (18%)
		IG_like	859..949	CDD:214653	19/104 (18%)
		FN3	955..1049	CDD:238020	24/103 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1043..1067		2/23 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1113..1144		5/31 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810