DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-V and Nphs1

DIOPT Version :9

Sequence 1:	NP_611765.2	Gene:	side-V / 37679	FlyBaseID:	FBgn0085400	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_062332.2	Gene:	Nphs1 / 54631	MGIID:	1859637	Length:	1256	Species:	Mus musculus

Alignment Length:	1165	Identity:	239/1165 - (20%)
Similarity:	396/1165 - (33%)	Gaps:	347/1165 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PATADEGPLSEILTAVGSEVALPCDL----------VPGTGIVD-------------KVQLVIWY 74
            |.::|.|   ::|...||..||...:          .||..::|             .::|....
Mouse   220 PQSSDNG---QLLVCEGSNPALATPIKASFTMNILFPPGPPVIDWPGLNEGHVRAGENLELPCIA 281

  Fly    75 RQGNVKPIYTFDARGRPLNLGIPWADESVFNKKAHFHHDTDPPALRIKNIQTSDAGL-YKCR-VD 137
            |.||......:...|:|::  |.|..|         |......::.:..::..|.|. ..|: .:
Mouse   282 RGGNPPATLQWLKNGKPVS--IAWGTE---------HAQAVAHSVLVMTVRPEDHGARLSCQSYN 335

  Fly   138 FHKSPTRNWRINVTVLVPPTALTILDHHGAEIRDQTAGPYLEGDSIDLTCLSSGGVPPPRVSWWR 202
            ...:.|:...|.:.|..||:|:|||   |:..:.       |..::.|.||:....|...:.||.
Mouse   336 SVSAETQERSITLQVTFPPSAVTIL---GSTSQS-------ENKNVTLCCLTKSSRPRVLLRWWL 390

  Fly   203 EHALIDDSFQVLPDG------SVRNVLRLKNIQRKDLLTMYTCQA-SNGHVVPALTKKVILDMNL 260
            ....:..:.:.:.||      |:.|:..|  ::|:|.....||:| |:........|.:.|::..
Mouse   391 GGRQLLPTDETVMDGLHGGHISMSNLTLL--VKREDNGLSLTCEAFSDAFSKETFKKSLTLNVKY 453

  Fly   261 PPLSLLLQG--LNHAVIAGTRSHVTCTAIGARPPPEIIWSKAGQIV----------RGATSSTSS 313
            |...|.::|  ...::..|||..:.|.|||..|.|.:.|.|..:.|          |....|...
Mouse   454 PAQKLWIEGPPEGQSIRTGTRVRLVCLAIGGNPEPSLTWLKDSRPVNDPRQSQEPRRVQLGSVEK 518

  Fly   314 DGNTTISELMLIPVPEDNERQVVCSISLNAG---ITSQQLHEGHTTVMTTLGNGHTGLYLKDSRV 375
            .|:|...||:||..|.||    :...|..||   .::|.:.:...|.:|.|.|...   |:....
Mouse   519 SGSTFSRELVLIIGPPDN----LAKFSCKAGQLSASTQLVVQFPPTNLTILANSSA---LRPGDA 576

  Fly   376 LNVT-----HAPIVNLNL---GAPLD-----PDNL-LKGT------------------------- 401
            ||:|     ..|.|||:|   |..||     |.:. .||:
Mouse   577 LNLTCVSISSNPPVNLSLDKEGERLDDVAAKPQSAPFKGSAASRSVFLRVSSRDHGHRVTCRAHS 641

  Fly   402 -----------------------------------DVYLECDVKANPAITRVEWYHSDKQLHSSR 431
                                               ...|...|.||||.....|.....:|..:.
Mouse   642 EALRETVSSFYRLNVLYPPEFLGEQVRAVTVVEQGQALLPVSVSANPAPEAFNWTFRGYRLSPAG 706

  Fly   432 G---IIISNQTLVLQGISKSSHGQYFCRASNLQGSVSSNEVYLDVKYPPVCKSESTIIRAALKQT 493
            |   .|:|...|.|..::::..|.|.....|.:|:..: .:.|||.|.|..::........:..:
Mouse   707 GPRHRILSGGALQLWNVTRADDGFYQLHCQNSEGTAEA-LLKLDVHYAPTIRALKDPTEVNVGGS 770

  Fly   494 INITCEVDANPVDNLNYKWHFNNSLESLIELPQLGQGAPVMLASGSDQSGYYQRSKRKHSHGMQQ 558
            ::|.|.|||||:....:.|      |.|                |.|:.........|.|.|...
Mouse   771 VDIVCTVDANPILPEMFSW------ERL----------------GEDEEELNLDDMEKMSKGSTG 813

  Fly   559 RLLHGRHGRMAAVRFEDEDEDGYGEFEEYGDEVGQPFTQMVYSNMVHKNHVESSKQQQRKQLSPQ 623
            ||           |.........|.::...|....|..:.:...:|              :.:||
Mouse   814 RL-----------RIRQAKLSQAGAYQCIVDNGVAPAARGLVRLVV--------------RFAPQ 853

  Fly   624 QQQQQ--QQMASGGSSGDSHT---------------PSGGVILERKRLVALHKQHHRGGVATPPT 671
            .....  .::|:.|.|..|.|               ...||.|:.:.......::|:|.|.:...
Mouse   854 VDHPTPLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHKYHQGVVHSSLL 918

  Fly   672 TTAAPPLNNVYSYHVESYESFGAISCVASSPMG--HSAPCWYHIQPADL--PEPVKNCTAYNATA 732
            |.|          :|.:.:.:....|.|::.:|  |:     :||...:  |:|.......:.:.
Mouse   919 TIA----------NVSAAQDYALFKCTATNALGSDHT-----NIQLVSISRPDPPLGLKVVSVSP 968

  Fly   733 NSLQIQCIPGYDGGIPQHFHAQIYDELNRQILYNASYKYSE--------FTVKRLPSDSVFVIRI 789
            :|:.::..||:|||:||.|      ::..:.|.:..:.|.:        ||:..|...:.:.|.:
Mouse   969 HSVGLEWKPGFDGGLPQRF------QIRYEALESPGFLYMDVLPAQATTFTLTGLKPSTRYRIWL 1027

  Fly   790 TAVNAQGASKVAYRLRGRTLSAPLLRTASSTA------------VLVQLTPLLGALVGVIATLIL 842
            .|.||.|.|.:..:....:::.|.|..|....            ..:.|.|:|.|:.|::  |:.
Mouse  1028 LASNALGDSGLTDKGIQVSITTPGLDQAPEDTDQPLPTEQPPGPPRLPLLPVLFAVGGLL--LLS 1090

  Fly   843 VAICVVIVIKFRSKRGG----RRHGSGADATTTEADKGSAEPLSRNMGSHS-------------- 889
            .|.||          ||    ||....|:..:.:.:.||.|...||....|
Mouse  1091 NASCV----------GGLLWRRRLRRLAEEISEKTEAGSEEDRIRNEYEESQWTGDRDTRSSTVS 1145

  Fly   890 ---------SLEDKNPDVVP--QEANSEDEF---HQEEKAF-DRLNMESQRILYTPPTRINTASP 939
                     |:.|.:|.:.|  :|.:....|   ..|:.|| ..|..|.:|: |.||
Mouse  1146 TAEVDPHYYSMRDFSPQLPPTLEEVSYRQAFTGIEDEDMAFPGHLYDEVERV-YGPP-------- 1201

  Fly   940 PPPSLSPTFGKQYGELSLTTNPAFSLYNTPQRAPAVQRPVYTAPPPLLSTRTPPNIYTRI 999
                  ..:|..|.|                    ||...|....|.:....|..||.::
Mouse  1202 ------GVWGPLYDE--------------------VQMDPYDLRWPEVKYEDPRGIYDQV 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-V	NP_611765.2	Ig	42..153	CDD:299845	23/135 (17%)
		IG_like	42..152	CDD:214653	23/134 (17%)
		IGc2	179..245	CDD:197706	18/72 (25%)
		IG_like	179..245	CDD:214653	18/72 (25%)
		Ig	<282..348	CDD:299845	23/78 (29%)
		IGc2	400..459	CDD:197706	16/121 (13%)
		FN3	719..798	CDD:214495	21/86 (24%)
Nphs1	NP_062332.2	Ig	52..128	CDD:299845
		IG_like	52..127	CDD:214653
		C2-set_2	155..242	CDD:285423	8/24 (33%)
		Ig	254..332	CDD:299845	15/88 (17%)
		IG_like	268..350	CDD:214653	15/92 (16%)
		C2-set_2	358..440	CDD:285423	22/93 (24%)
		Ig	459..544	CDD:299845	25/88 (28%)
		I-set	460..555	CDD:254352	28/98 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..516		4/24 (17%)
		Ig	563..646	CDD:299845	18/85 (21%)
		IG_like	670..750	CDD:214653	18/80 (23%)
		Ig	676..750	CDD:299845	18/74 (24%)
		Ig_3	753..834	CDD:290638	20/113 (18%)
		IG_like	762..848	CDD:214653	21/118 (18%)
		Ig	848..956	CDD:299845	23/136 (17%)
		IG_like	859..949	CDD:214653	19/104 (18%)
		fn3	956..1039	CDD:278470	21/88 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1048..1071		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1112..1143		6/30 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810