DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-V and NPHS1

DIOPT Version :9

Sequence 1:	NP_611765.2	Gene:	side-V / 37679	FlyBaseID:	FBgn0085400	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_004637.1	Gene:	NPHS1 / 4868	HGNCID:	7908	Length:	1241	Species:	Homo sapiens

Alignment Length:	1181	Identity:	247/1181 - (20%)
Similarity:	406/1181 - (34%)	Gaps:	343/1181 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SAAVFPRQPVAFVLVLATALSLVQGEQHPATADEGPLSEILTAVGSEVALPCDLVPGTGIVD--- 66
            :|.|.||......|::..|.|       ||.  |.|:....|.   .|..|    ||..:::
Human   201 TARVTPRSSDNRQLLVCEASS-------PAL--EAPIKASFTV---NVLFP----PGPPVIEWPG 249

  Fly    67 ----------KVQLVIWYRQGNVKPIYTFD--ARGRPLNLGIPWADESVFNKKAHFHHDTDPPAL 119
                      .::|....|.||  |:.|..  ..|:|::..  |..|         |......::
Human   250 LDEGHVRAGQSLELPCVARGGN--PLATLQWLKNGQPVSTA--WGTE---------HTQAVARSV 301

  Fly   120 RIKNIQTSDAGLYKCRVDFHKS---PTRNWRINVTVLVPPTALTILDHHGAEIRDQTAGPYLEGD 181
            .:..::..|.|. :...:.|.|   .|:...|.:.|..||:|:.||..     ..||     |..
Human   302 LVMTVRPEDHGA-QLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGS-----ASQT-----ENK 355

  Fly   182 SIDLTCLSSGGVPPPRVSWWREHALIDDSFQVLPDGSVRNVLRLKNI----QRKDLLTMYTCQA- 241
            ::.|:|:|....|...:.||.....:....:.:.||.....:.:.|:    :|:|.....||:|
Human   356 NVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAF 420

  Fly   242 SNGHVVPALTKKVILDMNLPPLSLLLQG--LNHAVIAGTRSHVTCTAIGARPPPEIIWSKAGQIV 304
            |.........|.:||::..|...|.::|  ....:.||||..:.|.|||..|.|.::|.|..:.|
Human   421 SEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTV 485

  Fly   305 ----------RGATSSTSSDGNTTISELMLIPVPEDNERQVVCSISLNAGITSQQLHEGHTTVMT 359
                      |....|....|:|...||:|:..|.||:.:..|.....:..|...:....|.| |
Human   486 TESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQFPPTNV-T 549

  Fly   360 TLGNGHTGLYLKDSRVLNVT-----HAPIVNLN----------LGAP------------------ 391
            .|.|...   |:....||:|     ..|.|||:          :.||
Human   550 ILANASA---LRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQ 611

  Fly   392 --------------------------------LDPDNL---------LKGTDVYLECDVKANPAI 415
                                            ..|:.|         ::..:..|...|.||||.
Human   612 VSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAP 676

  Fly   416 TRVEWYHSDKQLHSSRG---IIISNQTLVLQGISKSSHGQYFCRASNLQGSVSSNEVYLDVKYPP 477
            ....|.....:|..:.|   .|:|:..|.|..::::..|.|.....|.:|:..: .:.|||.|.|
Human   677 EAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEA-RLRLDVHYAP 740

  Fly   478 VCKSESTIIRAALKQTINITCEVDANPVDNLNYKWHFNNSLESLIELPQLGQGAPVMLASGSDQS 542
            ..::........:..:::|.|.|||||:....:.|      |.|                |.|:.
Human   741 TIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNW------ERL----------------GEDEE 783

  Fly   543 GYYQRSKRKHSHGMQQRL-LHGRHGRMAAVRFEDEDEDGYGEFEEYGDEVGQPFTQMVYSNMVHK 606
            ........|.|.|...|| :|  |.::|..          |.::...|....|..:.:...:|
Human   784 DQSLDDMEKISRGPTGRLRIH--HAKLAQA----------GAYQCIVDNGVAPPARRLLRLVV-- 834

  Fly   607 NHVESSKQQQRKQLSPQQQQQQ--QQMASGGSSGDSHT---------------PSGGVILERKRL 654
                        :.:||.:...  .::|:.|.|..|.|               ...||.|:.:..
Human   835 ------------RFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDP 887

  Fly   655 VALHKQHHRGGVATPPTTTAAPPLNNVYSYHVESYESFGAISCVASSPMGHSAPCWYHIQPADL- 718
            ......:|:|||.:...|.|          :|.:.:.:...:|.|::.:|....   :||...:
Human   888 RYTEHTYHQGGVHSSLLTIA----------NVSAAQDYALFTCTATNALGSDQT---NIQLVSIS 939

  Fly   719 -PEPVKNCTAYNATANSLQIQCIPGYDGGIPQHFHAQIYDELNRQILYNASYKY--------SEF 774
             |:|.......:.|.:|:.::..||:|||:||.|..: |:.|.     ...:.|        :.|
Human   940 RPDPPSGLKVVSLTPHSVGLEWKPGFDGGLPQRFCIR-YEALG-----TPGFHYVDVVPPQATTF 998

  Fly   775 TVKRLPSDSVFVIRITAVNAQGASKVAYRLRGRTLSAPLLRTAS------------STAVLVQLT 827
            |:..|...:.:.:.:.|.||.|.|.:|.:.....::.|.|...|            |....:.|.
Human   999 TLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSGLPLL 1063

  Fly   828 PLLGALVGVIATLILVAICVVIVIKFR----------------------------SKRGGRRHGS 864
            |:|.||.|::  |:..|.||..|:..|                            |:..|.|...
Human  1064 PVLFALGGLL--LLSNASCVGGVLWQRRLRRLAEGISEKTEAGSEEDRVRNEYEESQWTGERDTQ 1126

  Fly   865 GADATTTEADKGSAEPLSRNMGSHSSLEDKNPDVVPQEANSEDEFHQEEKAFDR-LNMESQRILY 928
            .:..:|||     |||..|      ||.|.:|.:.|.         |||.::.| ...|.:.:.:
Human  1127 SSTVSTTE-----AEPYYR------SLRDFSPQLPPT---------QEEVSYSRGFTGEDEDMAF 1171

  Fly   929 TPPTRINTASPPPPSLSPTFGKQYGELSLTTNPAFS---LYNTPQRAPAVQRPVYTAPPPLLSTR 990
            .                   |..|.|:..|..|:.:   ||:..|..|      :....|..:.:
Human  1172 P-------------------GHLYDEVERTYPPSGAWGPLYDEVQMGP------WDLHWPEDTYQ 1211

  Fly   991 TPPNIYTRIPG 1001
            .|..||.::.|
Human  1212 DPRGIYDQVAG 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-V	NP_611765.2	Ig	42..153	CDD:299845	22/128 (17%)
		IG_like	42..152	CDD:214653	22/127 (17%)
		IGc2	179..245	CDD:197706	16/70 (23%)
		IG_like	179..245	CDD:214653	16/70 (23%)
		Ig	<282..348	CDD:299845	21/75 (28%)
		IGc2	400..459	CDD:197706	15/61 (25%)
		FN3	719..798	CDD:214495	22/86 (26%)
NPHS1	NP_004637.1	V-set	38..119	CDD:284989
		IG_like	38..113	CDD:214653
		C2-set_2	141..228	CDD:285423	10/35 (29%)
		Ig	240..321	CDD:299845	15/94 (16%)
		IG_like	254..336	CDD:214653	17/95 (18%)
		Ig	345..424	CDD:299845	20/88 (23%)
		Ig	445..530	CDD:299845	25/84 (30%)
		I-set	446..541	CDD:254352	26/94 (28%)
		Ig	549..632	CDD:299845	13/85 (15%)
		IG_like	558..642	CDD:214653	9/83 (11%)
		I-set	646..736	CDD:254352	20/90 (22%)
		Ig	662..736	CDD:299845	18/74 (24%)
		Ig_3	739..820	CDD:290638	22/114 (19%)
		IG_like	748..821	CDD:214653	22/106 (21%)
		Ig8_hNephrin_like	834..942	CDD:143250	23/134 (17%)
		IG_like	845..935	CDD:214653	19/102 (19%)
		fn3	942..1023	CDD:278470	21/86 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1057		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1099..1137		7/42 (17%)
		Binds to NPHS2	1160..1241		16/88 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810