DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment side-V and side-III

DIOPT Version :10

Sequence 1:NP_611765.2 Gene:side-V / 37679 FlyBaseID:FBgn0085400 Length:1174 Species:Drosophila melanogaster
Sequence 2:NP_001036681.1 Gene:side-III / 4379844 FlyBaseID:FBgn0083949 Length:1689 Species:Drosophila melanogaster


Alignment Length:1681 Identity:349/1681 - (20%)
Similarity:527/1681 - (31%) Gaps:705/1681 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 FVLVL-ATALSLVQGEQHPATADEGPLSEIL--TAVGSEVALPCDLVPGTGIVDKVQLVIWYRQG 77
            |.|.| |..:||..| |.....|:.|:|.:.  ..:|...:||||:.| ....|:|.:|:|:|:.
  Fly    29 FALFLFAAHISLTSG-QIDWDDDDDPVSTVAVEAVLGRTASLPCDIEP-EAKDDRVYMVLWFRES 91

  Fly    78 NVKPIYTFDARGRPLNLGIPWADESVFNKKAHFHHDTDPPALRIKNIQTSDAGLYKCRVDFHKSP 142
            ..||:|:||.||||....:.|:|.:.|..:|:|.....|..|.:.|||..|.|:|:|||||..||
  Fly    92 AGKPLYSFDVRGRPFEKALYWSDTNSFGPRAYFVTGQQPAKLSVDNIQLDDEGVYRCRVDFQNSP 156

  Fly   143 TRNWRINVTVLVPPTALTILDHHGAEIRDQTAGPYLEGDSIDLTCLSSGGVPPPRVSWWREHALI 207
            |||.|||:||:|||..:.:.|..|.::.. ..||.||||:|.|||...||.|.|.|:|.      
  Fly   157 TRNHRINLTVIVPPHQILVYDASGRDVAG-AVGPLLEGDNIVLTCEVRGGRPEPTVTWM------ 214

  Fly   208 DDSFQVLPDGS--------VRNVLRLKNIQRKDLLTMYTCQASNGHVVPALTKKVILDMNLPPLS 264
             :..:.|..||        ..|.|.:..|.|..|...|.|||||..:|..:.:.:.::|.|.|.|
  Fly   215 -NGTRTLEAGSGVSMGRHVTVNRLEVAQISRSALNNTYRCQASNTKLVAPVERSIRIEMLLKPTS 278

  Fly   265 LLLQGLNHAVIAGTRSHVTCTAIGARPPPEIIWSKAGQIVRGATSSTSSDGNTTISELMLIPVPE 329
            :.|........:.|:.::||...|:.|..||.|::..:..:....|||......||.|...|.||
  Fly   279 VNLTNKLKVFASNTQYNLTCIVAGSVPDTEIKWTQNNRPFKRGLLSTSQSNGRVISTLTFYPQPE 343

  Fly   330 DNERQVVCSISLNAGITSQQLHEGHTTVMTTLGNGHTGLYLKDSRVLNVTHAPIVNLNLGAPLDP 394
            |:...:.|              ||....:....       ::||.::||.:.|.|.|:||:.|.|
  Fly   344 DDGTMLKC--------------EGSNPRLQNSA-------IEDSLMMNVIYPPQVTLSLGSTLRP 387

  Fly   395 DNLLKGTDVYLECDVKANPAITRVEWYHSDKQL--HSSRGIIISNQTLVLQGISKSSHGQYFCRA 457
            |::.:|.|||.||.:|:||...|:.|.|..:.:  :.|.|||||.::||||.:.:...|.|.|.|
  Fly   388 DDIKEGDDVYFECHIKSNPKEHRIMWSHDGQPVTQNVSWGIIISTRSLVLQRVGRIHSGFYACSA 452

  Fly   458 SNLQGSVSSNEVYLDVKYPPVCKSES-TIIRAALKQTINITCEVDANPVDNLNYKW--------- 512
            :|.:|...|..|.|.::|.|||.|.| |:|.|:|::.:.|.|.|:::|.: ::::|         
  Fly   453 ANDRGETQSAPVNLRIRYAPVCSSSSITVIGASLEEDVPIPCRVNSDPPE-IDFEWTFSTSGEHF 516

  Fly   513 -------------------------------HFNNSLESLIEL---------------------- 524
                                           ||.:.:|::.||                      
  Fly   517 EVPSGHYATIQDPTMTTTSDVRRTVVESNETHFESYVETVSELIYTPKGERDYGTLACYGRNAIG 581

  Fly   525 -----------PQLGQGA-------PVMLASGSDQSG-------------YYQRSKRKHSHGMQQ 558
                       |....||       |.::.|.|..|.             .|.|.:..:.|....
  Fly   582 KQSDPCVFQVVPAAKPGALRNCTLRPYVVTSASLNSSNQTTMHANQILPTQYGRHESNYPHMEYV 646

  Fly   559 RLLHGRHG------RMAAVRFEDEDEDGYGEFEEYGDEVGQ------PFTQMVYSNMVHKNHVES 611
            |..|...|      ..||.|....:::..|.     ...||      ..||.....:..:.....
  Fly   647 RERHNSSGGNNNGTAPAAGRNNVANKNMRGR-----TSAGQAKSNNKQLTQQQLQRLKKRTSFTP 706

  Fly   612 S-------KQQQRKQLSPQQQQQQQQ--MASGGSSGDSHTPSGGVILE----------------- 650
            |       :|:||||||.||||.|||  .|:...||..:.|.|.....                 
  Fly   707 SQTLAAIERQRQRKQLSQQQQQLQQQHHQATATKSGGDNKPDGSPAKSSKQRMRRASRDPQIQQQ 771

  Fly   651 ----------------------------------------------------------------- 650
                                                                             
  Fly   772 QQHQQQQQHQLHAATSITSSQRKQAESNLSTSHLGKGSSSSSRSRRSSSSNINSKSNNGKQPAKY 836

  Fly   651 -RKRLVALHKQHHR-------------------------------------------------GG 665
             .||...:|||.|:                                                 ..
  Fly   837 FNKRQKNMHKQKHQQKLKQLKGTTNEHNSNIIHHYAALSSSLRRRKRLAANDILATVAAASTSAS 901

  Fly   666 VATPPTTTA-------------------------------------------------------- 674
            :::||.::|                                                        
  Fly   902 LSSPPASSAASLAATATAAVEIEQDVSAVDAPAADSGSNNKRSRKSLTILDKQKQQQEQQQLLPP 966

  Fly   675 -APPLNN-----VYSYHVESYESFGAISCVASSPMGHSAPC------------------------ 709
             ||.::|     :...:|:...:..|...||:. :...||.                        
  Fly   967 NAPQISNQPVAAISGNNVKETAATSAHGAVAAG-VKDKAPSSKEDSTDNDNDSDGDEDDDDDDDD 1030

  Fly   710 ---------------------WYHIQPADLPEPVKNCTA-------------------------- 727
                                 ..|...|||.|.|.....                          
  Fly  1031 GAEIDAETETNDEEEDEDEGGEAHDDDADLDEDVAQLATDADYLADGPGDLQEYETVEEVDGQAK 1095

  Fly   728 -------------------------------YN----------------ATA------------- 732
                                           ||                .||             
  Fly  1096 HVHMLSLEEQLDLESLEDNVEEEDDGEVDDMYNVSDDDFVASVALSTSDTTAATPLQRTTEGPHI 1160

  Fly   733 ----------------------------------------------------------------- 732
                                                                             
  Fly  1161 REKATQSQTQTDSATEWQLPHFDYSRMEYSFSNGVVTQSLLGGGAVTGAGHDGFAGGGTINFDNY 1225

  Fly   733 -----NSLQIQCIPGYDGGIPQHFHAQIYDELNRQILYNASYKYSEFTVKRLPSDSVFVIRITAV 792
                 ::::::|:||||||:.|.|..:.||....::..|.|..|.:..|.|:....:..:.....
  Fly  1226 DNIIYSTMELECMPGYDGGLQQQFFLEAYDSKTMKLRLNMSSTYMDVPVFRIDLSDLMPMDYYPD 1290

  Fly   793 NAQGASKVAYRLRGRTLSAPLL---------RTASSTAVLVQLTPLLGALVGVIATLILVAICVV 848
            .......|.|.:..:..|.|::         ...|...:.:.:.||...|.|.:.| :.:|:..|
  Fly  1291 AHPALHLVVYSVNQKGRSEPIVLENVPINEADKRSDGRMGLSILPLAALLAGTLFT-VGIAVLSV 1354

  Fly   849 IVIKFRSKRG-GRRH-------GSGADATTTEADKGSAEPLSRNMGSHSSLE---------DKNP 896
            :||..|.:|| |.|:       ..|.|.|.|       .||....| |..|.         :|.|
  Fly  1355 VVIAVRRRRGQGARNMCDDKDKHLGMDVTVT-------APLETGAG-HQRLVVAYTLKQGIEKQP 1411

  Fly   897 DVVPQEANSEDEFHQEEKAFDRLNMESQRILYTPPTRINTASPPPPSLSPTFGKQYGELSLTTNP 961
            |::..:.::                         ||..:.:||                      
  Fly  1412 DILSAQKSA-------------------------PTGGDASSP---------------------- 1429

  Fly   962 AFSLYNTPQRAPAVQRPVYTAPPPLLSTRTPPNIYTRIPGRGGGGGGATVTAAGA------GGYH 1020
                                     |..| |..::....|.|||||||...|:.|      ||:.
  Fly  1430 -------------------------LGNR-PSGLFAGGGGGGGGGGGAAGLASAAPMTGNTGGHK 1468

  Fly  1021 LPAYETRTSP--TSPYGSTTTCTMPLLGGQSNGSLQSGGVGGVGGLVG---GGA-----CNTLPH 1075
            ...|: ..:|  .||...::|.           .|:|....|.|||||   ||:     .:.:|.
  Fly  1469 TTDYD-GNAPHLNSPPSQSSTL-----------KLESDPAAGGGGLVGARSGGSNPPLLYDAMPT 1521

  Fly  1076 PGSLHVGGISAALTSSVTSGNITIGAAQSLLTSPRSQTATYSTTLGGVQSPLLMGG 1131
            .......|:|.|   |.::|..|.|::.:|  |....|.:.:....|...|   ||
  Fly  1522 LSRYEQLGLSMA---SYSAGAGTGGSSSTL--SSAGSTVSNAMAANGSAGP---GG 1569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
side-VNP_611765.2 V-set 42..153 CDD:462230 48/112 (43%)
Ig_3 178..243 CDD:464046 26/72 (36%)
Ig 274..359 CDD:472250 21/84 (25%)
Ig strand B 280..284 CDD:409353 0/3 (0%)
Ig strand C 294..298 CDD:409353 2/3 (67%)
Ig strand E 320..324 CDD:409353 2/3 (67%)
Ig strand F 334..345 CDD:409353 1/10 (10%)
Ig strand G 355..358 CDD:409353 0/2 (0%)
Ig 400..466 CDD:472250 28/67 (42%)
Ig strand B 403..407 CDD:409353 2/3 (67%)
Ig strand C 416..421 CDD:409353 1/4 (25%)
Ig strand E 438..442 CDD:409353 1/3 (33%)
Ig strand F 452..457 CDD:409353 2/4 (50%)
Ig strand G 465..468 CDD:409353 1/2 (50%)
FN3 719..798 CDD:214495 22/234 (9%)
side-IIINP_001036681.1 V-set 59..166 CDD:462230 46/107 (43%)
Ig_3 190..257 CDD:464046 26/73 (36%)
Ig 289..359 CDD:472250 21/83 (25%)
Ig strand C 308..312 CDD:409468 2/3 (67%)
Ig strand E 335..338 CDD:409468 1/2 (50%)
Ig strand F 348..353 CDD:409468 1/18 (6%)
Ig_3 374..454 CDD:464046 34/79 (43%)

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