DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-V and side-VII

DIOPT Version :9

Sequence 1:	NP_611765.2	Gene:	side-V / 37679	FlyBaseID:	FBgn0085400	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	1159	Identity:	295/1159 - (25%)
Similarity:	472/1159 - (40%)	Gaps:	275/1159 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VLVLATALSLVQGEQHPATADEGPLSEILTAVGSEVALPCDLVPGTGIVDKVQLVIWYRQGNVKP 81
            :|:...||.|::..   ..:.:.|:.:|.:.||..:.|||::....|  |:..||:|||.....|
  Fly     4 LLLFMLALQLIESS---IGSKDVPIHQIESIVGENIYLPCNVTTYDG--DEPVLVLWYRDDKGTP 63

  Fly    82 IYTFDARGRPLNLGIPWADESVFNKKAHFHHDTDPPALRIKNIQTSDAGLYKCRVDFHKSPTRNW 146
            ||:.|.|.........|:|:|||..:|:|..|.:|..|.|:|.|.||:|.|:|||||.|:.|.|.
  Fly    64 IYSIDIRAGVSKAPKRWSDDSVFGDRAYFIFDKEPGKLSIQNTQASDSGTYRCRVDFLKAQTINS 128

  Fly   147 RINVTVLVPPTALTILDHHGAEIRDQTAGPYLEGDSIDLTCLSSGGVPPPRVSWWREHALIDDSF 211
            ||.:.|:.||..:.|.|....| |....|||.|||.:.|.|...||.|.|.:||:|:...|....
  Fly   129 RIRLNVISPPKQVIIRDSSNVE-RSTVVGPYSEGDIVSLKCQVIGGYPTPTISWYRDGIEIPCEL 192

  Fly   212 QVLPDGSVRNV-LRLKNIQRKDLLTMYTCQASNGHVVPALTKKVILDMNLPPLSLLLQGLNHAVI 275
            ..|..|.:... :.|.::.|:||.:..||:|.:....|.:...|.:|||..||::.|.|.:..:.
  Fly   193 SHLAGGKIIECEITLPSLGREDLNSRLTCRALSHPRAPIVEAVVQIDMNFAPLNIRLLGAHQPLS 257

  Fly   276 AGTRSHVTCTAIGARPPPEIIWSKAGQIVRGATSSTSSDGNTTISELMLIPVPEDNERQVVCSIS 340
            ||.|..:.|.:.|:|||..|.|.:.|..:...|.:||||||.|.|.|.:.....|..:.:.|. :
  Fly   258 AGRRYDLLCQSAGSRPPAVITWWQNGIRLEKTTETTSSDGNQTTSTLSISLSKSDAGKYLSCK-A 321

  Fly   341 LNAGITSQQLHEGHTTVMTTLGNGHTGLYLKDSRVLNVTHAPIVNLNLGAPLDPDNLLKGTDVYL 405
            .|..:.|:.|.:|..                    |::.:.|...:.||..|||..|.:|||||.
  Fly   322 YNHAVPSEPLEDGWK--------------------LDIQYVPEAYVRLGTSLDPSTLREGTDVYF 366

  Fly   406 ECDVKANPAITRVEWYHSDKQL-HS-SRGIIISNQTLVLQGISKSSHGQYFCRASNLQGSVSSNE 468
            :|.|.|:|.:.|:||.|:::.| |: |.|:||||.:|||||:::::.|.|.|...|.:|...|..
  Fly   367 DCLVMAHPNVFRIEWRHNEQPLSHNISLGVIISNHSLVLQGVTRATAGNYSCVGFNAEGEGISAP 431

  Fly   469 VYLDVKYPPVC-KSESTIIRAALKQTINITCEVDANPVDNLNYKWHFNNSLESLIELPQLGQGAP 532
            ..|::.|.|.| :::..:...|.::...:.|.|||||.: :.:.|.||||.||:
  Fly   432 FALNILYAPTCAQNQKKVYGIAKQEDAKVMCTVDANPRE-VEFSWTFNNSAESI----------- 484

  Fly   533 VMLASGSDQSGYYQRSKRKHSHGMQQRLLHGRHGRMAAVRFEDEDEDGYGEFEEYGDEVGQPFTQ 597

  Fly   485 ----------------------------------------------------------------- 484

  Fly   598 MVYSNMVHKNHVESSKQQQRKQLSPQQQQQQQQMASGGSSGDSHTPSGGVILERKRLVALHKQHH 662
                 .|..||:                     :.||.:|..::||    |.|.
  Fly   485 -----DVATNHI---------------------IRSGTTSIVTYTP----ITEL----------- 508

  Fly   663 RGGVATPPTTTAAPPLNNVYSYHVESYESFGAISCVASSPMG-HSAPCWYHIQPADLPEPVKNCT 726
                                        .:|.:.|:||:.:| ...||.:||..|..||.|.|||
  Fly   509 ----------------------------DYGTLLCLASNKIGKQRVPCVFHIIAAGRPEKVHNCT 545

  Fly   727 AYNATANSLQIQCIPGYDGGIPQHFHAQIYDELNRQILYNASYKYSEFTVKRLPSDSVFVIRITA 791
            ..|.:..||.:.|..|::||:||.|:.::.|...::|..|.:....:|||..|...|::.:.|.|
  Fly   546 VNNISMTSLTVTCSDGFNGGLPQSFNLELLDSYTQEIKANITSTIPKFTVPGLSPGSIYRLNIYA 610

  Fly   792 VNAQGASKVAYRLRGRTLSAPLLR------TASSTAVL---VQLTPLLGALVGVIATLILVAICV 847
            .|.:|.|..|      .::|.:||      |:..|..|   :..:|::...:|:...:::..:.:
  Fly   611 FNTKGRSDPA------IVNAAMLRMPEKQLTSEQTHNLRAELLFSPVMSLTIGLTLAVLVAVLAI 669

  Fly   848 VIVIKFRSKRGGRRHGSGADATTTEADKGSAEPLSRNMGSH--SSLEDKNPDVVPQEANSEDEF- 909
            ::.::.......||............|: |..|..::.||.  ...::|||||||:....:::.
  Fly   670 ILALRIPCTASSRRRQKELSNENISRDE-SPGPSDKSSGSKEVDDCDEKNPDVVPESIEPDEQAE 733

  Fly   910 ----HQEEKAFDRLNMESQRILYTPPTRINTASPPPPSLSPTFGKQY---------------GEL 955
                .|:....|.....::.|.......:..|.   .||..:.|..|               ||:
  Fly   734 SIRKRQQISTIDTNRSPNRGIFVNEQQHLTAAE---ISLRASHGIGYCTLRSGMHAQAQSSVGEI 795

  Fly   956 SLTTNP-----AFSLYNTPQRAPAVQRPVYTAPPPLLSTRTPPNIYTRI---PGRGGGGGGATVT 1012
            |:...|     :.|....|:::   .:.|:......::...|.:.:.::   .||...||
  Fly   796 SINVTPHVYSNSISQCTLPRQS---SQNVWNNYNCNITGARPTSTFHQLTFPQGRVNVGG----- 852

  Fly  1013 AAGAGGYHLPAYETRTSPTSPYGSTTTCTMPLLGGQSNGSLQSGGVGGVGGLVGGGACNTLPHPG 1077
                   |.||........||            ...||.|:.|             :.||||.|
  Fly   853 -------HNPAQPLHGHAPSP------------SQASNSSMAS-------------STNTLPQP- 884

  Fly  1078 SLHVGGISAAL--TSSVTSGNITIGAAQSLLTSPRSQTATYSTTLGGVQSPLLM 1129
              |..|.:.|:  .:....|.:.||.|...:.|.....:....|   ||:||::
  Fly   885 --HPHGRTIAMHHMNQAQCGRVCIGIASDGIHSAEQNVSDDEVT---VQTPLMI 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-V	NP_611765.2	Ig	42..153	CDD:299845	45/110 (41%)
		IG_like	42..152	CDD:214653	45/109 (41%)
		IGc2	179..245	CDD:197706	22/66 (33%)
		IG_like	179..245	CDD:214653	22/66 (33%)
		Ig	<282..348	CDD:299845	21/65 (32%)
		IGc2	400..459	CDD:197706	29/60 (48%)
		FN3	719..798	CDD:214495	28/78 (36%)
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	44/103 (43%)
		V-set	32..134	CDD:284989	44/103 (43%)
		IGc2	160..>214	CDD:197706	17/53 (32%)
		Ig	262..328	CDD:299845	21/66 (32%)
		IG_like	264..323	CDD:214653	20/59 (34%)
		IGc2	360..425	CDD:197706	30/64 (47%)
		Ig_3	456..519	CDD:290638	26/208 (13%)
		FN3	538..620	CDD:238020	29/81 (36%)
		FAM176	643..741	CDD:291517	17/98 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470101
Domainoid	1	1.000	42	1.000	Domainoid score	I12438
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23448at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23278
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1676
	7	6.850