DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-V and nrm

DIOPT Version :9

Sequence 1:	NP_611765.2	Gene:	side-V / 37679	FlyBaseID:	FBgn0085400	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster

Alignment Length:	943	Identity:	213/943 - (22%)
Similarity:	335/943 - (35%)	Gaps:	261/943 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SAAVFPRQPVAFVLVLATALSLVQGEQHPATADEGPLSEILTAVGSE----VALPCDLVPGTGIV 65
            |..|..|..::..|||...|:||          :...:::.|.:..:    |.|||.       |
  Fly    16 SNCVAVRSSISLSLVLVLCLALV----------DSSTAQVDTTISQQESQSVVLPCP-------V 63

  Fly    66 D-----KVQLVIWYRQGNVKPIYTFDARGRPLNLGIPWADESVFNKKAHFHH----DTDPPALRI 121
            |     |:..:.|::.         |.|...:.||    |.:|.:....|..    :.:|..|.|
  Fly    64 DAEKCGKLHSLNWFKG---------DDRIAAMLLG----DSNVTSVNKEFDERVTVEQNPYRLVI 115

  Fly   122 KNIQTSDAGLYKCRVDFHKSPT-----RNWRINVTVLVPPTALTILDHHGAEIRD-QTAGPYLEG 180
            |:::.:|..:|.|...|.....     ..:||.:.||||||.:.|||..|..|:: ...||..|.
  Fly   116 KDLKIADEDIYLCDTTFFIPEETCDNFNGYRIELRVLVPPTEVVILDAKGDRIKNGSVVGPMQER 180

  Fly   181 DSIDLTCLSSGGVPPPRVSWWR----------EHALIDDSFQVLPDGSVRNVLRLK-NIQRKDLL 234
            .|:..||......|.|.|||:|          .|.|:        ||...:.|.|. .:.|:||.
  Fly   181 QSLKATCTVRNTRPQPEVSWFRGTKRLTTYSPTHDLV--------DGLYTSTLELDWTLSREDLA 237

  Fly   235 TMYTCQASNGHVVPALTKKVILDMNLPPLSLLLQGLNHAVIAGTRSHVTCTAIGARPPPEIIWSK 299
            ....|:..:..:......|..:|:.:.|.|:.:.|:.|..:.|::..:||...||||...:.|..
  Fly   238 QDIECRVKSAAIQNVTVTKFSVDLQVRPTSIDINGVKHHTVQGSKVVLTCDIHGARPAVNLTWYN 302

  Fly   300 AGQIVRG---------ATSSTSSDGN-TTISELMLIPVPEDNER-------QVVCSISLNAGITS 347
            ...|:..         :.|...|||. .|.|||:......:|:|       .:|..|:....|:|
  Fly   303 TTTIISSGENEITEVRSKSLEKSDGTFHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISS 367

  Fly   348 QQLHEGHTTVMTTLGNGHTGLYLKDSRVLNVTHAPIVNLNLGAPLDPDNLLKGTD--VYLECDVK 410
                                     :..|.|.:.|:|.::      |..:...|.  |.|.|:..
  Fly   368 -------------------------ALTLEVLYPPVVKVS------PSAITANTSEIVLLNCEYF 401

  Fly   411 ANPA-ITRVEWYHSDKQLHSS-----RGIIISNQTLVLQGISKSSHGQYFCRASNLQG-SVSSNE 468
            |||| :|:||||.:|..::.:     :|....|..||::...|...|.|.|:.||..| ..|..:
  Fly   402 ANPASLTQVEWYRNDILVNVNDTTHYKGGNSENVALVIKSTEKEDIGNYSCQLSNNIGKGTSDQK 466

  Fly   469 VYLDVKYPP---VCKSESTIIRAALKQTINITCEV-DANPVDNLNYKWHFNNSLESLIELPQLGQ 529
            :.|||:|.|   :.......::.:.:..:.:.|.| ||||......:|:.|::|  |.|||..
  Fly   467 INLDVQYAPTVEILMIPEGPVKESDESNVTLFCNVLDANPSVLTKVRWYANSTL--LKELPDC-- 527

  Fly   530 GAPVMLASGSDQSGYYQRSKRKHSHGMQQRLLHGRHGRMAAVRFEDEDEDGYGEFEEYGDEVGQP 594
                            :.::....|....:||....||              |.|..|..|
  Fly   528 ----------------EETREDLCHIDPSKLLLESIGR--------------GFFYNYSCE---- 558

  Fly   595 FTQMVYSNMVHKNHVESSKQQQRKQLSPQQQQQQQQMASGGSSGDSHTPSGGVILERKRLVALHK 659
                      ..|......:.:.|:|....:.        |.:..||.|          |||:.|
  Fly   559 ----------GFNAAGWGPRSEDKELLVHYEP--------GPAALSHFP----------LVAVKK 595

  Fly   660 QH--------------------HRGG------VATPPTTTAAPPLNNVYSYHVESYESFGAISCV 698
            :.                    .|||      :.|...|.....|::..:|           ||.
  Fly   596 KSVTFSCSVDDPGFPESNRFRWLRGGRGPLQDIVTKDWTVEPVGLDSRTNY-----------SCY 649

  Fly   699 ASSPMGHSAPCWYHIQPADLPEPVKNCTAY--------NATANSLQIQCIPGYD-----GGIP-- 748
            |.:..|.......:::....|..:||...|        |||. :.:|:|:|..|     .|:|
  Fly   650 AYNEGGKGVMATVNLEVHAPPFFIKNLPPYTGILHSSPNATL-TCRIECVPRCDISWQKDGVPIE 713

  Fly   749 ----QHFHAQIY-DELNRQILYNASYKYSEFTVKRLPSDSVFVIRITAVNAQGASK---VAYRLR 805
                ::|..:.| |.......:.:......|.:...| ||.|.|.....|....|.   |...:|
  Fly   714 RNDSRYFIKEKYMDASPATGDFESMLSVLHFNMPNWP-DSKFNIEADNANYSCVSTGNIVGGSIR 777

  Fly   806 GRTL----SAPLLRTASSTAVLVQLTPLLGALV 834
            .||.    .||...|.|...|.||...:.|.::
  Fly   778 SRTYFGIEYAPENTTVSENIVYVQEDTIPGRVI 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-V	NP_611765.2	Ig	42..153	CDD:299845	26/128 (20%)
		IG_like	42..152	CDD:214653	26/127 (20%)
		IGc2	179..245	CDD:197706	20/76 (26%)
		IG_like	179..245	CDD:214653	20/76 (26%)
		Ig	<282..348	CDD:299845	21/82 (26%)
		IGc2	400..459	CDD:197706	22/66 (33%)
		FN3	719..798	CDD:214495	23/98 (23%)
nrm	NP_001246890.1	Ig	44..152	CDD:299845	26/127 (20%)
		Ig	176..248	CDD:299845	21/79 (27%)
		Ig	277..354	CDD:299845	19/76 (25%)
		IG_like	383..463	CDD:214653	26/79 (33%)
		Ig	394..463	CDD:143165	24/68 (35%)
		Ig_3	585..652	CDD:290638	17/87 (20%)
		Ig	685..>719	CDD:299845	9/34 (26%)
		IG_like	788..869	CDD:214653	7/23 (30%)
		Ig	<811..869	CDD:299845	213/943 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810