DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-V and kirre

DIOPT Version :9

Sequence 1:	NP_611765.2	Gene:	side-V / 37679	FlyBaseID:	FBgn0085400	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	1229	Identity:	252/1229 - (20%)
Similarity:	386/1229 - (31%)	Gaps:	480/1229 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ATALSLVQGEQHPATADEG-------PLSEILTAVGSEVALPCDLVPGTGIVDKVQLVIWYRQGN 78
            :.|.|....|..|...|.|       |..: ...|||.|.|||      .:::||..:.|
  Fly    62 SAAASSANDESKPKGGDNGGQHFAMEPQDQ-TAVVGSRVTLPC------RVMEKVGALQW----- 114

  Fly    79 VKPIYTFD--ARGRPLNLGIPWADESVFNKKAHFHHDTDPP-ALRIKNIQTSDAGLYKCRVDFHK 140
                 |.|  ..|:..||       |.|.:.:....|.:.. :|.|..:...|...|:|:|.  .
  Fly   115 -----TKDDFGLGQHRNL-------SGFERYSMVGSDEEGDFSLDIYPLMLDDDAKYQCQVG--P 165

  Fly   141 SP-----TRNWRINVTVLVPPTALTILDHHGAEIRDQTAGPYL---EGDSIDLTCLSSGGVPPPR 197
            .|     .|:....:||||||.|..|           |.|.||   |...|:|.|:|.||.|...
  Fly   166 GPQGEQGIRSRFAKLTVLVPPEAPKI-----------TQGDYLVTTEDREIELECVSQGGKPAAE 219

  Fly   198 VSWWREHALIDDSFQVLPDG--------------SVRNVLRLKNIQRKDLLTMYTCQASNGHVVP 248
            ::|      ||....||..|              :.|::|:|.. :::...|.:||||.|.....
  Fly   220 ITW------IDGLGNVLTKGIEYVKEPLADSRRITARSILKLAP-KKEHHNTTFTCQAQNTADRT 277

  Fly   249 ALTKKVILDMNLPPLSLLLQGLNHAVIAGTRSHVTCTAIGARPPPEIIWSKAGQIVRGATSSTSS 313
            ..:.|::|::...|..::      :|:.|..:                   .|:|..||....|.
  Fly   278 YRSAKLLLEVKYAPKVIV------SVVGGALA-------------------GGKIPEGAEVILSC 317

  Fly   314 DGNTTISELML-------IPVPEDNERQVVCSISLNAGITSQQLHEG--HTTVMTTLGNGHTGLY 369
            ..:....||..       :...:...:.::.::       |:|.|:.  ...|:..:|..
  Fly   318 QADANPHELSYRWFINDELMTGDFTTKMIIHNV-------SRQYHDAIVKCEVVNAVGKS----- 370

  Fly   370 LKDSRVLNVTHAPI-------VNLNLGAPLDPDNLLKGTDVYLECDVKANPAITRVEWY--HSDK 425
             :.|:.|:::..|:       |..:|||           .|.:.|||..||. ..:||.  :||:
  Fly   371 -EQSKKLDISFGPVFRQRPVSVEADLGA-----------TVSMRCDVAGNPE-PEIEWISENSDQ 422

  Fly   426 QLHSSRGIIISNQTLVLQGISKSSHGQYFCRASNLQGSVSSNEVYLDVKYPPVCKSESTIIRAAL 490
                    ::.....:...:|..:.|:|||:|..........|..|.||..|:..|.. :....:
  Fly   423 --------VVGVAAELKLKVSSETAGRYFCKAVVNGFPEIGAEATLYVKRAPIITSHK-VQFGGV 478

  Fly   491 KQTINITCEVDANPVDNLNYKWHFNNSLESLIELPQLGQGAPVMLASGSDQSGYYQRSKRKHSHG 555
            ...:.|.|...:.|... :..|.|...:.::               |.:|...|.   ..:|
  Fly   479 GGRVKIDCLAFSIPKAE-HILWSFEGKIINM---------------SSADPDIYI---FEEH--- 521

  Fly   556 MQQRLLHGRHGRMAAVRFEDEDEDGYGEF-----EEYGD---------EVGQ-PFTQMVYSNM-- 603
                  |...|..||:...|.....:|::     ..||.         |.|. |...:|..:|
  Fly   522 ------HLPEGVRAALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMFC 580

  Fly   604 ------------VHKNHVESSKQQQRKQLSPQQQQQQQQMASGGSSGDSHTPSGGVILERKRLVA 656
                        |::      |::.||:..|                      ..||.|..
  Fly   581 VAIILMIVMIIIVYR------KRRSRKKPMP----------------------ADVIPEAS---- 613

  Fly   657 LHKQHHRGGVATPPTTTAAPPLNNVYS------YHVESYESFG---AISCVASSPMGHSAPCWYH 712
                  |||          ..||.:.|      |.||..|:.|   ||: :..|||..     ..
  Fly   614 ------RGG----------DKLNELKSELRSKAYDVEYSEAGGDGLAIN-LTQSPMPD-----VQ 656

  Fly   713 IQPADLPEPVKNCTAYNATANSLQIQCIPGYDGGIPQHFHAQIYDELNRQILYNASYK------- 770
            ::.|.|..|:.....::        :...|..||...:....|.:..|:|   ..:||
  Fly   657 MKGATLGVPLAGPVKFD--------ERFSGDFGGDRYNRQCHIKNLKNQQ---ETAYKGSPQANG 710

  Fly   771 ---YSEFTVKRLP--SDSVFVIRITAVNAQGASKVAYRLRGRTLSAPLLRTASSTAVLVQLTPLL 830
               |.|:.:...|  .:...|:    |.:.|..|:.   .|...||.|..:|::|.
  Fly   711 YAHYFEYALDYSPPGGEGAAVV----VGSGGVGKLK---NGGMNSATLPHSAAATV--------- 759

  Fly   831 GALVGVIATLILVAICVVIVIKFRSKRGGRRHGSGADATTTEADKGSAEPLSRNMGSHSSLEDKN 895
                                     ..||..:|.||.
  Fly   760 -------------------------NGGGAGNGGGAS---------------------------- 771

  Fly   896 PDVVPQEANSEDEFHQEEKAF-------DRLNMESQRILYTPPTRINTA--SP-PPPSLSPTFGK 950
               :|:....|.:..|:...|       :.::.....|...|..|.|::  .| ||||
  Fly   772 ---LPRNQRHEIQQSQQSNGFLGQPLLQNGIDSRFSAIYGNPYLRTNSSLLPPLPPPS------- 826

  Fly   951 QYGELSLTTNPAFSLYNTPQRAPAVQRPVYTAPPPLLSTRTPPNIYTRIPGRGGG----GGGATV 1011
                   |.|||    .||            ||||..:.|     :.......||    .|||.:
  Fly   827 -------TANPA----ATP------------APPPYHAAR-----HGHAHHANGGLKHFVGGAVI 863

  Fly  1012 TAAGAGGYHLPAYETRTSPTSPYGSTTTCTMPLLGGQSNGSLQSGGVGGVG-GLVGGGACNTLPH 1075
            |                  |||.|:..     :.||...||..||| |||| |:..||:
  Fly   864 T------------------TSPVGNVN-----INGGGGGGSTPSGG-GGVGVGVAAGGS------ 898

  Fly  1076 PGSLHVGGISAALTSSVTSGNITIGAAQSLLTSPRSQTATYSTTLGGVQSPLLMGGGGN 1134
                 |.|.|:.||:|                         |.||..  :||..||.||
  Fly   899 -----VSGSSSNLTAS-------------------------SNTLAA--TPLAGGGVGN 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-V	NP_611765.2	Ig	42..153	CDD:299845	27/118 (23%)
		IG_like	42..152	CDD:214653	26/117 (22%)
		IGc2	179..245	CDD:197706	23/79 (29%)
		IG_like	179..245	CDD:214653	23/79 (29%)
		Ig	<282..348	CDD:299845	7/72 (10%)
		IGc2	400..459	CDD:197706	16/60 (27%)
		FN3	719..798	CDD:214495	15/90 (17%)
kirre	NP_001245505.1	Ig	87..183	CDD:299845	28/121 (23%)
		IG_like	88..182	CDD:214653	27/119 (23%)
		C2-set_2	189..279	CDD:285423	28/107 (26%)
		Ig_2	307..379	CDD:290606	13/84 (15%)
		I-set	382..462	CDD:254352	23/99 (23%)
		IGc2	396..446	CDD:197706	17/69 (25%)
		Ig	466..561	CDD:299845	19/123 (15%)
		IG_like	478..561	CDD:214653	17/110 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910