DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9899 and CTR9

DIOPT Version :9

Sequence 1:	NP_611764.1	Gene:	CG9899 / 37676	FlyBaseID:	FBgn0034829	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	NP_014496.2	Gene:	CTR9 / 854020	SGDID:	S000005505	Length:	1077	Species:	Saccharomyces cerevisiae

Alignment Length:	967	Identity:	211/967 - (21%)
Similarity:	394/967 - (40%)	Gaps:	195/967 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 RQQHDPHLQVTKGFLWMLSSSRAQDADALLISVLRNHPKNILALIGRACLAYNRQDYIGALGYFK 150
            |..:|..|:.:..|   :.|..|:|..:     .|....|.|.|:.||.|.|.:::|:.:|..|:
Yeast   151 RGHYDKALETSDLF---VKSIHAEDHRS-----GRQSKPNCLFLLLRAKLLYQKKNYMASLKIFQ 207

  Fly   151 SVLLIQPQGMADVWVGIGHCFWKMGELEKAQLSFQIALEHNGQCLNAALALALVKFEHNDEQSYQ 215
            .:|:|.|....|..:|||.|||::.:.:.|..|:|.||:.|.:..:|::.:.|.:|..:...|..
Yeast   208 ELLVINPVLQPDPRIGIGLCFWQLKDSKMAIKSWQRALQLNPKNTSASILVLLGEFRESFTNSTN 272

  Fly   216 DG--KMLLTAA-------YKENNKNPDLLSILAGMYYADGNHKLVWS-FAGNAIKFT--ANKHIE 268
            |.  |...|.|       :.||..||.||::|...||..|:::.|.. :....:|.:  ..|.:.
Yeast   273 DKTFKEAFTKALSDLNNIFSENQHNPVLLTLLQTYYYFKGDYQTVLDIYHHRILKMSPMIAKIVL 337

  Fly   269 SRNYFQIAKSYHATGQFESAKKYYLLSAKSAPDGYILPLVGVAQMYLHEGELNRSKAFLESFLTS 333
            |.:.|...::::|.|.:..:...:..|.|...|. :|..:|:.|..:....|..|....|:...:
Yeast   338 SESSFWCGRAHYALGDYRKSFIMFQESLKKNEDN-LLAKLGLGQTQIKNNLLEESIITFENLYKT 401

  Fly   334 EPDEPVVMDLLAKIYLEYKCPEKI-------------DKAIEMLVKVVESASYHQN----TNSWL 381
            ......:..:|..:|.......|.             :||::.|.:.::.....:|    :.::|
Yeast   402 NESLQELNYILGMLYAGKAFDAKTAKNTSAKEQSNLNEKALKYLERYLKLTLATKNQLVISRAYL 466

  Fly   382 NLAFAYEQKRLWAHGVNAYQKAIDIYLSQG--------HQIPIEWLNNLASSQLMAKMPEKALNT 438
            .::..||.:       |.|:.::| |||:.        .:||:|.|||||....:.....||
Yeast   467 VISQLYELQ-------NQYKTSLD-YLSKALEEMEFIKKEIPLEVLNNLACYHFINGDFIKA--- 520

  Fly   439 LDDALSKCRVMNSDNKTTNLLSLQYNRGLVLEELHMFTLAAENYKSITKEYSSYH---------D 494
             ||...:.:...||...:..::|:||.....|:..     .|..:||..:.:|.|         :
Yeast   521 -DDLFKQAKAKVSDKDESVNITLEYNIARTNEKND-----CEKSESIYSQVTSLHPAYIAARIRN 579

  Fly   495 CYLRLGVMAIQKNNHTQAIEHLKDILVEDNLNMTARTYMGDCFKG----LSLDKFATFNYNMILA 555
            .||:.....|:.::.:..:..|.|:...|   :..|::.|...|.    .:.:|..|.|...::.
Yeast   580 LYLKFAQSKIEDSDMSTEMNKLLDLNKSD---LEIRSFYGWYLKNSKERKNNEKSTTHNKETLVK 641

  Fly   556 RQS-------KFTNTYVSMAMGNFCLEKLQNWIAEGNFRAARKQQE-------KALQCFGKILDC 606
            ..|       ...|.||::|             .:|......|:||       ||:|.:.|:|..
Yeast   642 YNSHDAYALISLANLYVTIA-------------RDGKKSRNPKEQEKSKHSYLKAIQLYQKVLQV 693

  Fly   607 NPKNLWAANGIGAVLSSCNNLSAGGAIFKQIIE-CGNKCIPAIINSAHIALVSGQYRLAIQTYER 670
            :|.|::||.|:..:.:....|.....|.:::.: ..|:.:.  :|.||..|...:|..||:.||.
Yeast   694 DPFNIFAAQGLAIIFAESKRLGPALEILRKVRDSLDNEDVQ--LNLAHCYLEMREYGKAIENYEL 756

  Fly   671 CLK--DHLPKNRVDVMHCLAKALYDNG--------------DARKAKMWLLKVRHLVPHDPFVIF 719
            .||  |: .|.|..:::.|.:|.|...              :|:.|....:|..........|.|
Yeast   757 VLKKFDN-EKTRPHILNLLGRAWYARAIKERSVNFYQKALENAKTALDLFVKESSKSKFIHSVKF 820

  Fly   720 NLGLAIKKETEQALALPRPQL-------DELMGLDGLLKVAFKLFCHIN-------LNHPKISVR 770
            |:.| :..:..:.|....|:.       |.|.|    ||...:||..:|       :...::..|
Yeast   821 NIAL-LHFQIAETLRRSNPKFRTVQQIKDSLEG----LKEGLELFRELNDLKEFNMIPKEELEQR 880

  Fly   771 V-------------SAKYAEDCQNLMTELIAKKRQASESHAMEED----------RVQLQKQ--R 810
            :             |....|:.:...:..|.:.|:..|.:.::|.          |::|:||  .
Yeast   881 IQLGETTMKSALERSLNEQEEFEKEQSAKIDEARKILEENELKEQGWMKQEEEARRLKLEKQAEE 945

  Fly   811 YRDHIEHQRQQELQREEEERVRRENLKIQRKEVLERTRKIISAPLAPDVPKKSAGNGRAKKNQEN 875
            || .::.:.|:.:|..|...:...|:| ...::.::..:.       |..|......|:.|.:.:
Yeast   946 YR-KLQDEAQKLIQEREAMAISEHNVK-DDSDLSDKDNEY-------DEEKPRQKRKRSTKTKNS 1001

  Fly   876 GDGKAKKSGPPKKKTRKRAAGKEQEDIEPLKKPK---------SKEFI-DTDDDNSE 922
            |:.|.:|:      .:|..:..:::|.:.:|||.         |.||| |:|::.::
Yeast  1002 GESKRRKA------AKKTLSDSDEDDDDVVKKPSHNKGKKSQLSNEFIEDSDEEEAQ 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9899	NP_611764.1	TPR_11	125..191	CDD:290150	25/65 (38%)
		TPR repeat	125..155	CDD:276809	11/29 (38%)
		TPR repeat	161..189	CDD:276809	11/27 (41%)
		TPR	174..443	CDD:223533	68/305 (22%)
		TPR repeat	272..297	CDD:276809	4/24 (17%)
		PEP_TPR_lipo	275..>735	CDD:274350	109/528 (21%)
		TPR repeat	303..333	CDD:276809	6/29 (21%)
		TPR repeat	338..369	CDD:276809	6/43 (14%)
		TPR repeat	376..406	CDD:276809	6/33 (18%)
		TPR repeat	416..444	CDD:276809	10/27 (37%)
		TPR repeat	458..488	CDD:276809	7/29 (24%)
		TPR repeat	493..520	CDD:276809	6/35 (17%)
		TPR repeat	580..605	CDD:276809	8/31 (26%)
		TPR repeat	610..640	CDD:276809	6/30 (20%)
		TPR repeat	645..673	CDD:276809	9/27 (33%)
		TPR repeat	680..710	CDD:276809	7/43 (16%)
CTR9	NP_014496.2	PilF	118..>254	CDD:225605	34/110 (31%)
		TPR repeat	217..247	CDD:276809	12/29 (41%)
		TPR repeat	255..293	CDD:276809	7/37 (19%)
		TPR repeat	371..401	CDD:276809	6/30 (20%)
		TPR repeat	406..450	CDD:276809	6/43 (14%)
		TPR repeat	457..496	CDD:276809	10/46 (22%)
		TPR repeat	501..527	CDD:276809	10/29 (34%)
		ANAPC3	676..755	CDD:289650	20/80 (25%)
		TPR repeat	697..726	CDD:276809	6/28 (21%)
		TPR_12	728..799	CDD:290160	18/73 (25%)
		TPR repeat	731..759	CDD:276809	9/29 (31%)
		TPR repeat	768..796	CDD:276809	3/27 (11%)
		Cas_DxTHG	<800..964	CDD:286533	32/169 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346058
Domainoid	1	1.000	87	1.000	Domainoid score	I1841
eggNOG	1	0.900	-	-		E2759_KOG2002
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	230	1.000	Inparanoid score	I730
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54530
OrthoFinder	1	1.000	-	-		FOG0003745
OrthoInspector	1	1.000	-	-		otm46817
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.860