DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9899 and ELF8

DIOPT Version :9

Sequence 1:	NP_611764.1	Gene:	CG9899 / 37676	FlyBaseID:	FBgn0034829	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	NP_178674.7	Gene:	ELF8 / 815177	AraportID:	AT2G06210	Length:	1091	Species:	Arabidopsis thaliana

Alignment Length:	998	Identity:	239/998 - (23%)
Similarity:	433/998 - (43%)	Gaps:	130/998 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSTYIEEAMEFYAIGKGADFKAIIEKGIASCMTTYST---YDR-ELYKAYALLATYLSNHAFKII 65
            |..::..|.|::..||...|:.|:|:|.:|.:..|..   |:| .:..|.....:||.....|..
plant    40 LDLWLIIAREYFKQGKIEQFRQILEEGSSSDIDEYYADVKYERIAILNALGAYYSYLGKTETKNR 104

  Fly    66 KSRPAFQAMAINCFDQLDSLRQQHDPHLQVTKGFLWMLSSSRAQDADALLISVLRNHPKNILALI 130
            :....| ..|...:::...: ..|:|...|.||.| :|:.....:|......||...|.|:.||:
plant   105 EKEEQF-ISATRYYNKASRI-DMHEPSTWVGKGQL-LLAKGEIDNALQAFKIVLDTAPDNVPALL 166

  Fly   131 GRACLAYNRQDYIGALGYFKSVLLIQPQGMADVWVGIGHCFWKMGELEKAQLSFQIALEHNGQCL 195
            |:|.:.:||..:..:|..:|..|.:.|...|.|.:||| |.:|:|:|:||:.:|...|:.:...:
plant   167 GQASVEFNRGRFSESLQLYKRALQVFPGCPAAVRLGIGXCRYKLGQLDKARQAFDRVLQLDPDNV 231

  Fly   196 NAALALALVKFEHNDEQSYQDGKMLLTAAYKENNKNPDLLSILAGMYYADGNHKLVWSFAGNAIK 260
            .|.:||.::..:.||....:.|...:..|::........|:.||..::..|.|.||......|:.
plant   232 EALVALGIMDLQANDSIGMRKGMDRMQQAFEIYPYCASALNYLANHFFFTGQHFLVEQLTETALA 296

  Fly   261 FTANKHIESRNYFQIAKSYHATGQFESAKKYYLLSAKSA---PDGYILPLVGVAQMYLHEGELNR 322
            .|.:...:|.:::.:|:|||:.|.||.|..||:.:.|..   |..::.|..|:.|:.|..|||..
plant   297 VTTHGPTKSHSFYNLARSYHSKGDFEKAGMYYMAAIKETNNNPHEFVFPYFGLGQVQLKLGELKG 361

  Fly   323 SKAFLESFLTSEPDEPVVMDLLAKIYLEYKCPEKIDKAIEMLVKVVESASYHQNTNSWLNLAFAY 387
            |....|..|...||....:..|..:|.:.   .:.:||:|.:.|..:...  ::..:::.|....
plant   362 SVFNFEKVLEVYPDNCETLKALGHLYTQL---GQNEKALEYMRKATKLDP--RDAQAFVGLGELL 421

  Fly   388 EQKRLWAHGVNAYQKAIDIYLSQGHQIPIEWLNNLASSQLMAKMPEKALNTLDDALSK------- 445
            ......| .::|::.|..:....|.::|||.||::.:.....:..|.||....:||..
plant   422 ISSDTGA-ALDAFKMARTLMKKGGQEVPIEVLNDIGALHFEREEFESALENFKEALGDGIWISFL 485

  Fly   446 ----------------------CRVMNSD-------NKTTNLLSLQYNRGLVLEELHMFTLAAEN 481
                                  .|::.|.       ||.|.|    :|...:||::|....|...
plant   486 DEKENLEQTGVSVLGYKDTGIFHRLIESGHSVDVPWNKVTTL----FNLARLLEQIHKTEAATFM 546

  Fly   482 YKSITKEYSSYHDCYLRLGVMAIQKNNHTQAIEHLKDILVEDNLNMTARTYMGDCFKGLSLDKFA 546
            |:.|..:|..|.|.||||...|..:||...|||.:.:.|..|:.|..|.:.:|:    |.|.
plant   547 YRLILFKYPGYIDAYLRLAASAKAQNNLPLAIELVNEALKVDDKNPNALSLLGE----LELK--- 604

  Fly   547 TFNYNMILARQSKFTNTYVSMAMGNFCLEKLQNWIAEGNFRAARKQQ-----------EKALQCF 600
              |.:.:.|:::.......:....::.:..|.||    |:.||.:.:           |||.:.:
plant   605 --NDDWVKAKETFRAANDATDGKDSYAILSLGNW----NYFAAMRNEKRNPKLEATHLEKAKELY 663

  Fly   601 GKILDCNPKNLWAANGIGAVLSSCNNLSAGGAIFKQIIECGNKCI----PAI-INSAHIALVSGQ 660
            .|:|..:..|::||||.|.||:..........:|.|:.|..:..:    |.: :|.||:....|.
plant   664 TKVLTQHNSNMYAANGSGIVLAEKGQFDIAKDVFTQVQEAASGSVFLQMPDVWVNLAHVYFAQGN 728

  Fly   661 YRLAIQTYERCLKDHLPKNRVDVMHCLAKALYDNGDARKAKMWLLKVRHLVPHDPFVIFNLGLAI 725
            :.|.::.|:.||:.........::..||:..|:....::.|..||:..||.|.:....|:||..:
plant   729 FALTVKMYQNCLRKFFYNTDSQILLYLARTHYEAEQWQECKKTLLRAIHLTPSNYTFRFDLGAVM 793

  Fly   726 KKETEQALALPRPQLDELMGLDGLLKVAFKLFCHIN---------LNHPKISVRVSAKYAEDCQN 781
            :|.:...|...:...||:.......:.|.::|..::         .:..||...|     :.|.:
plant   794 QKSSSSTLQKKKRTADEVRSTVAEAENAVRVFTQLSAASDLHVHGFDSKKIQTHV-----QYCSH 853

  Fly   782 LMTELIAKKRQASESHAMEEDRVQLQKQ-----RYRDHIEHQRQQELQ-REEEERVRRENLKIQR 840
            |:......:..|.:.......|:::.:|     ..|...|.||:.:|: |::||.:||  || |.
plant   854 LLEAAKVHREAAEQEELQNRQRLEVARQAALAEEARRKAEEQRKYQLEKRKQEEELRR--LK-QE 915

  Fly   841 KEVLERTRKIISAPLAPDVPKKSAGNGRAKKNQENGDGKAKKSGPPKKKTRKRAAGKEQEDIEPL 905
            :|..:|.::        .....:.|:.:.|...|:.||::|    |.::.||:...:.::|
plant   916 EEKFQRIKE--------QWKSSTPGSNKRKDRVEDDDGESK----PSERRRKKGGKRRKKD---- 964

  Fly   906 KKPKSKEFID------TDDDNSE 922
            |..:::.:.|      |.||::|
plant   965 KSSRARHYEDDEEEAATMDDHNE 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9899	NP_611764.1	TPR_11	125..191	CDD:290150	24/65 (37%)
		TPR repeat	125..155	CDD:276809	10/29 (34%)
		TPR repeat	161..189	CDD:276809	12/27 (44%)
		TPR	174..443	CDD:223533	66/271 (24%)
		TPR repeat	272..297	CDD:276809	10/24 (42%)
		PEP_TPR_lipo	275..>735	CDD:274350	125/514 (24%)
		TPR repeat	303..333	CDD:276809	10/29 (34%)
		TPR repeat	338..369	CDD:276809	6/30 (20%)
		TPR repeat	376..406	CDD:276809	4/29 (14%)
		TPR repeat	416..444	CDD:276809	8/27 (30%)
		TPR repeat	458..488	CDD:276809	8/29 (28%)
		TPR repeat	493..520	CDD:276809	11/26 (42%)
		TPR repeat	580..605	CDD:276809	8/35 (23%)
		TPR repeat	610..640	CDD:276809	10/29 (34%)
		TPR repeat	645..673	CDD:276809	8/32 (25%)
		TPR repeat	680..710	CDD:276809	6/29 (21%)
ELF8	NP_178674.7	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	131	1.000	Domainoid score	I1693
eggNOG	1	0.900	-	-		E2759_KOG2002
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54530
OrthoDB	1	1.010	-	-		D396755at2759
OrthoFinder	1	1.000	-	-		FOG0003745
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14027
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.890