DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9899 and TTC21B

DIOPT Version :9

Sequence 1:	NP_611764.1	Gene:	CG9899 / 37676	FlyBaseID:	FBgn0034829	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	NP_079029.3	Gene:	TTC21B / 79809	HGNCID:	25660	Length:	1316	Species:	Homo sapiens

Alignment Length:	991	Identity:	192/991 - (19%)
Similarity:	349/991 - (35%)	Gaps:	277/991 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 ALIGRACLAYNRQDYIGALGYFKSVLLIQPQGMADVWVGIGHCFWKMGELEKAQLSFQIALEHNG 192
            ||:|:|.....||:|.|||.....:::..|..:.        .|.|       ::..|:||:...
Human   180 ALLGKAQCLEMRQNYSGALETVNQIIVNFPSFLP--------AFVK-------KMKLQLALQDWD 229

  Fly   193 QCLNAALALALVKFEHNDEQSYQDGKMLLTAAY---------KENNKNPDLLSIL-------AGM 241
            |.:..|..|.|     .|.|:.:  .:.:.|.|         |.:.|..:|.:.|       |.:
Human   230 QTVETAQRLLL-----QDSQNVE--ALRMQALYYVCREGDIEKASTKLENLGNTLDAMEPQNAQL 287

  Fly   242 YY--------ADGNHKLVWSFAGNAIK--FTANKHIESRNYFQIAKSYHATGQFESAKKYYLLSA 296
            :|        ..|..:|:.......::  |:.|.. :|....::.......|:.:.|.|:| .:|
Human   288 FYNITLAFSRTCGRSQLILQKIQTLLERAFSLNPQ-QSEFATELGYQMILQGRVKEALKWY-KTA 350

  Fly   297 KSAPDGYILPLVGVAQMYLHEGELNRSKAFLESFLT-----------------------SEPDEP 338
            .:..:..:..|||..|..|.||:|..:...|| ||.                       ::..|.
Human   351 MTLDETSVSALVGFIQCQLIEGQLQDADQQLE-FLNEIQQSIGKSAELIYLHAVLAMKKNKRQEE 414

  Fly   339 VV----------------------------MDLLAKIYLEYK--CPEK-----------IDKAIE 362
            |:                            .|.|.:|.:||.  ||.:           :.:.|.
Human   415 VINLLNDVLDTHFSQLEGLPLGIQYFEKLNPDFLLEIVMEYLSFCPMQPASPGQPLCPLLRRCIS 479

  Fly   363 MLVKVVES----------------------ASYH------QNTNSWLNLAFAYEQKRLWAHGVNA 399
            :|..||.:                      |:::      ::..|:.:......|..|....|..
Human   480 VLETVVRTVPGLLQTVFLIAKVKYLSGDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQEKVKL 544

  Fly   400 YQKAIDIYLSQGHQIPIEWLNNLASSQLMAKMPE--KALNTLDDALS-------KCRVMNSDNKT 455
            ..:::::.||...::....|.:|..:|...||.|  .|:.||..|:|       .....:.|.||
Human   545 CSQSLELCLSYDFKVRDYPLYHLIKAQSQKKMGEIADAIKTLHMAMSLPGMKRIGASTKSKDRKT 609

  Fly   456 TNLLSLQYNRGLVLEELHMFTLAAENYKSITK-------EYSSYHDCYLRLGV----MAIQKNNH 509
            .  :...:...:.||.:.:..|..|.::: ||       |:|...: .:|:.:    :|:.:.:.
Human   610 E--VDTSHRLSIFLELIDVHRLNGEQHEA-TKVLQDAIHEFSGTSE-EVRVTIANADLALAQGDI 670

  Fly   510 TQAIEHLKDILVEDNLNMTARTYMGDCFKGLSLDKFATFNYNMILARQSKFTNTYVSMAMGNFCL 574
            .:|:..|:::..|....:.||..|.|.:.....||.........:|  .:..|....:.:|:..:
Human   671 ERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIA--ERMANPRSFLLLGDAYM 733

  Fly   575 EKLQNWIAEGNFRAARKQQEKALQCFGKILDCNPKNLWAANGIGAVLSSCNNLSAGGAIFKQIIE 639
            ..|              :.|:|:..:.:.|:.|||:...|:.:|..|...:|.|.....::..::
Human   734 NIL--------------EPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALK 784

  Fly   640 CGNK---CIPAIINSAHIALVSGQYRLAIQTYERCLKDHLPKNRVDVMHCLAKALYDNGDARKAK 701
            .|.|   |    .:.|.:.|....|..|.:..:..|. |.|.|.:       .||.::|   :.:
Human   785 TGQKNYLC----YDLAELLLKLKWYDKAEKVLQHALA-HEPVNEL-------SALMEDG---RCQ 834

  Fly   702 MWLLKVRHLVPHDPFVIFNLG---LAIKKETE-QALALPRPQLDELMGLDGLLKVAFKLFCHINL 762
            :.|.||...:.       .||   .|:::..| ||..|.|.|:::...:.....:|.::...|
Human   835 VLLAKVYSKME-------KLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEI-- 890

  Fly   763 NHPKISV------------RVSAKYAEDCQNLMTE-------------------LIAKKRQASES 796
              .|.||            |.:..:.|....:|.|                   |:.:..|.:|:
Human   891 --AKHSVAQRDYEKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEA 953

  Fly   797 HAMEEDRVQLQKQRYRDHIEHQRQQELQREEEERVRRENLKIQRKEVLERTRKIISAPLAPDVPK 861
            ..|....:..:||.|...:.| .||.|:|:.:..:....|    .::|.|..|:...|....:.:
Human   954 ATMMMADLMFRKQDYEQAVFH-LQQLLERKPDNYMTLSRL----IDLLRRCGKLEDVPRFFSMAE 1013

  Fly   862 KSAGNGRAKKNQENGDGKAK-----KSGPPKKKTRKRAAGKEQED---------IEPLKKPKSK- 911
            |.  |.|||  .|.|....|     .:|.|....|.....::..|         ||....|.::
Human  1014 KR--NSRAK--LEPGFQYCKGLYLWYTGEPNDALRHFNKARKDRDWGQNALYNMIEICLNPDNET 1074

  Fly   912 ------EFIDTDDDNS 921
                  |.:|.|..||
Human  1075 VGGEVFENLDGDLGNS 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9899	NP_611764.1	TPR_11	125..191	CDD:290150	16/62 (26%)
		TPR repeat	125..155	CDD:276809	10/26 (38%)
		TPR repeat	161..189	CDD:276809	4/27 (15%)
		TPR	174..443	CDD:223533	68/388 (18%)
		TPR repeat	272..297	CDD:276809	4/24 (17%)
		PEP_TPR_lipo	275..>735	CDD:274350	108/578 (19%)
		TPR repeat	303..333	CDD:276809	12/52 (23%)
		TPR repeat	338..369	CDD:276809	11/71 (15%)
		TPR repeat	376..406	CDD:276809	4/29 (14%)
		TPR repeat	416..444	CDD:276809	10/29 (34%)
		TPR repeat	458..488	CDD:276809	6/36 (17%)
		TPR repeat	493..520	CDD:276809	4/30 (13%)
		TPR repeat	580..605	CDD:276809	2/24 (8%)
		TPR repeat	610..640	CDD:276809	5/29 (17%)
		TPR repeat	645..673	CDD:276809	4/27 (15%)
		TPR repeat	680..710	CDD:276809	6/29 (21%)
TTC21B	NP_079029.3	PEP_TPR_lipo	<48..550	CDD:274350	70/394 (18%)
		TPR 1	108..141
		TPR repeat	109..136	CDD:276809
		TPR repeat	141..173	CDD:276809
		TPR 2	145..178
		TPR repeat	178..205	CDD:276809	10/24 (42%)
		TPR 3	180..211		11/30 (37%)
		TPR repeat	212..239	CDD:276809	7/41 (17%)
		TPR 4	285..323		6/38 (16%)
		TPR repeat	323..353	CDD:276809	6/30 (20%)
		TPR 5	324..357		6/33 (18%)
		TPR repeat	358..382	CDD:276809	8/23 (35%)
		TPR 6	492..525		1/32 (3%)
		TPR repeat	496..520	CDD:276809	1/23 (4%)
		TPR_19	505..571	CDD:291240	9/65 (14%)
		TPR repeat	525..555	CDD:276809	4/29 (14%)
		TPR 7	563..596		11/32 (34%)
		TPR repeat	563..591	CDD:276809	10/27 (37%)
		TPR 8	617..650		8/33 (24%)
		TPR repeat	688..717	CDD:276809	7/30 (23%)
		TPR_11	721..784	CDD:290150	14/76 (18%)
		TPR 9	722..755		7/46 (15%)
		TPR repeat	722..750	CDD:276809	4/41 (10%)
		TPR repeat	755..785	CDD:276809	5/29 (17%)
		TPR 10	757..789		6/31 (19%)
		TPR_11	762..820	CDD:290150	13/62 (21%)
		TPR repeat	790..817	CDD:276809	5/30 (17%)
		TPR 11	791..822		8/35 (23%)
		TPR 12	831..864		10/42 (24%)
		TPR repeat	831..859	CDD:276809	7/37 (19%)
		TPR 13	884..917		6/36 (17%)
		TPR repeat	884..912	CDD:276809	5/31 (16%)
		TPR_19	895..961	CDD:291240	9/65 (14%)
		TPR repeat	917..947	CDD:276809	3/29 (10%)
		TPR 14	919..951		4/31 (13%)
		TPR 15	952..985		10/33 (30%)
		TPR repeat	952..980	CDD:276809	8/28 (29%)
		TPR 16	1023..1056		6/32 (19%)
		TPR repeat	1023..1051	CDD:276809	5/27 (19%)
		TPR repeat	1159..1185	CDD:276809
		TPR 17	1197..1230
		TPR repeat	1198..1225	CDD:276809
		TPR_11	1200..1261	CDD:290150
		TPR repeat	1230..1260	CDD:276809
		TPR 18	1232..1264
		TPR 19	1266..1299
		TPR repeat	1266..1294	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000