DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9899 and Ctr9

DIOPT Version :9

Sequence 1:	NP_611764.1	Gene:	CG9899 / 37676	FlyBaseID:	FBgn0034829	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	NP_001094131.1	Gene:	Ctr9 / 293184	RGDID:	1311097	Length:	1173	Species:	Rattus norvegicus

Alignment Length:	983	Identity:	275/983 - (27%)
Similarity:	474/983 - (48%)	Gaps:	112/983 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSTYIEEAMEFYAIGKGADFKAIIEKGIASCMTTYSTYDRELYKAYALLATYLSNHAFK------ 63
            |..:|..|:|:|..||..:|..::|.........|..::::.......||.|....|.|
  Rat    41 LHIWIALALEYYKQGKTEEFVKLLEAARIDGNLDYRDHEKDQMTCLDTLAAYYVQQARKEKNKDN 105

  Fly    64 ---IIKSRPAFQAMAINCFDQLDSLRQQHDPHLQVTKGFLWMLSSSRAQDADALLISVLRNHPKN 125
               :|........||    |::....|.|    .:.:....:|...:...|||....||...|.|
  Rat   106 KKDLITQATLLYTMA----DKIIMYDQNH----LLGRACFCLLEGDKMDQADAQFHFVLNQSPNN 162

  Fly   126 ILALIGRACLAYNRQDYIGALGYFKSVLLIQPQGMADVWVGIGHCFWKMGELEKAQLSFQIALEH 190
            |.||:|:||:::|::||.|||.|:|..|...|...|:|.:|:||||.|:.:||||:|:|..|||.
  Rat   163 IPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALEL 227

  Fly   191 NGQCLNAALALALVKFEHNDEQSYQDGKMLLTAAYKENNKNPDLLSILAGMYYADGNHKLVWSFA 255
            |.:|:.|.:.||:::..:.:..|.::|..||:.||..:..||.:|:.||..::...::..|...|
  Rat   228 NSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLA 292

  Fly   256 GNAIKFTANKHIESRNYFQIAKSYHATGQFESAKKYYLLSAKSAPDGYILPLVGVAQMYLHEGEL 320
            .:|...|..:.:::.:.:|:|:|:|....::.|.:||..:.:.|...::||..|:.|||::.|:.
  Rat   293 LHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDK 357

  Fly   321 NRSKAFLESFLTSEPDEPVVMDLLAKIYLEYKCPEKIDKAIEMLVKVVESASYHQNTNSWLNLAF 385
            ..:....|..|.:.|:....|.:|..:|...:..||.|.|...|.||.|  .|..:..:|:.||.
  Rat   358 ENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTE--QYPDDVEAWIELAQ 420

  Fly   386 AYEQKRLWAHGVNAYQKAIDIYLSQGHQ--IPIEWLNNLASSQL----MAKMPEKALNTLDDALS 444
            ..||..:.. .::||..|..| |.:..|  :|.|.|||:.:...    :.:..:..|.:||.|.:
  Rat   421 ILEQTDIQG-ALSAYGTATRI-LQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKA 483

  Fly   445 KCRVMNSDNKTTNLLSL--QYNRGLVLEELHMFTLAAENYKSITKEYSSYHDCYLRLGVMAIQKN 507
            :.   ..|....|.:|:  .||...:.|.:..|..|.:.||:|.:|:.:|.|||||||.||..|.
  Rat   484 EA---EHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKG 545

  Fly   508 NHTQAIEHLKDIL-----------VEDNLNMTARTYMGDCFKGLSLDKFATFNYNMILARQSKFT 561
            |..:|.:..|:.|           :..||::..:.:      |....||     ..||.:.:..:
  Rat   546 NFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEW------GPGQKKF-----ERILKQPATQS 599

  Fly   562 NTYVSMAMGNFCLEKLQNWIAEGNFRAARKQQEKALQCFGKILDCNPKNLWAANGIGAVLSSCNN 626
            :||..:|:||..|:.|..  ...:....::.|::||..:.::|..:.|||:|||||||||:....
  Rat   600 DTYSMLALGNVWLQTLHQ--PTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGY 662

  Fly   627 LSAGGAIFKQIIECGNKCIPAIINSAHIALVSGQYRLAIQTYERCLKDHLPKNRVDVMHCLAKAL 691
            ......:|.|:.|.........:|.|||.:...||..|:|.||.||:........:|:..||:||
  Rat   663 FREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARAL 727

  Fly   692 YDNGDARKAKMWLLKVRHLVPHDPFVIFNLGLAIKKETEQALALPRPQLDELMGLDGLLKVAFKL 756
            :..|..::.|..|||.||:.|.|..::||:.|.:::.....|...:..|.|::.....|::|.:.
  Rat   728 FKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVKELELAHRY 792

  Fly   757 FCHINL--NHPKISVRVSAKYAEDCQNLMTEL---IAKKRQASESHAMEEDRVQLQKQRYRDHIE 816
            |.:::.  :..:..:.::|..|..|.:|:::.   :|:.|:..|    ||..::.::::.::.:
  Rat   793 FSYLSKVGDKMRFDLALAASEARQCSDLLSQAQYHVARARKQDE----EERELRAKQEQEKELL- 852

  Fly   817 HQRQQELQREEEERVR----RENLKIQRKEVLERTRKIISAPLAPDVPKKSAGNGRAKKNQENGD 877
              ||:.|:.:||:|:|    ::.|..||.:.:|:|:.|:          ...|...|.|.::.|.
  Rat   853 --RQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNIL----------MFTGETEATKEKKRGG 905

  Fly   878 G---KAKKSG--------------PPKKKTRKRAA------GKEQEDIEPLKK-----PKSKEFI 914
            |   ::||.|              |..||.:||..      |:|:|..|..||     ||.:|
  Rat   906 GGGRRSKKGGEFDEFVNDDTDDDLPISKKKKKRKGSGSEQEGEEEEGGERKKKRRRRPPKGEE-- 968

  Fly   915 DTDDDNSE 922
            .:|||.:|
  Rat   969 GSDDDETE 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9899	NP_611764.1	TPR_11	125..191	CDD:290150	34/65 (52%)
		TPR repeat	125..155	CDD:276809	16/29 (55%)
		TPR repeat	161..189	CDD:276809	15/27 (56%)
		TPR	174..443	CDD:223533	78/274 (28%)
		TPR repeat	272..297	CDD:276809	7/24 (29%)
		PEP_TPR_lipo	275..>735	CDD:274350	139/478 (29%)
		TPR repeat	303..333	CDD:276809	9/29 (31%)
		TPR repeat	338..369	CDD:276809	10/30 (33%)
		TPR repeat	376..406	CDD:276809	8/29 (28%)
		TPR repeat	416..444	CDD:276809	8/31 (26%)
		TPR repeat	458..488	CDD:276809	9/31 (29%)
		TPR repeat	493..520	CDD:276809	13/26 (50%)
		TPR repeat	580..605	CDD:276809	3/24 (13%)
		TPR repeat	610..640	CDD:276809	13/29 (45%)
		TPR repeat	645..673	CDD:276809	11/27 (41%)
		TPR repeat	680..710	CDD:276809	11/29 (38%)
Ctr9	NP_001094131.1	PEP_TPR_lipo	<110..781	CDD:274350	209/698 (30%)
		TPR repeat	131..157	CDD:276809	5/25 (20%)
		TPR repeat	165..191	CDD:276809	13/25 (52%)
		TPR repeat	196..227	CDD:276809	16/30 (53%)
		TPR repeat	269..297	CDD:276809	7/27 (26%)
		TPR repeat	306..334	CDD:276809	7/27 (26%)
		TPR repeat	340..370	CDD:276809	9/29 (31%)
		TPR repeat	375..406	CDD:276809	10/30 (33%)
		TPR repeat	412..437	CDD:276809	7/25 (28%)
		TPR repeat	444..487	CDD:276809	10/45 (22%)
		TPR repeat	501..525	CDD:276809	8/23 (35%)
		TPR repeat	530..560	CDD:276809	15/29 (52%)
		TPR repeat	565..593	CDD:276809	6/38 (16%)
		TPR repeat	648..675	CDD:276809	11/26 (42%)
		TPR repeat	680..712	CDD:276809	12/31 (39%)
		TPR repeat	717..743	CDD:276809	9/25 (36%)
		MSCRAMM_SdrC	<971..1173	CDD:380146	4/6 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2002
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54530
OrthoDB	1	1.010	-	-		D396755at2759
OrthoFinder	1	1.000	-	-		FOG0003745
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14027
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.890