DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9899 and tpr1

DIOPT Version :9

Sequence 1:	NP_611764.1	Gene:	CG9899 / 37676	FlyBaseID:	FBgn0034829	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	NP_594620.1	Gene:	tpr1 / 2542077	PomBaseID:	SPAC27D7.14c	Length:	1039	Species:	Schizosaccharomyces pombe

Alignment Length:	921	Identity:	215/921 - (23%)
Similarity:	383/921 - (41%)	Gaps:	174/921 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 VLRNHPKNILALIGRACLAYNRQDYIGALGYFKSVLLIQPQGMADVWVGIGHCFWKMGELEKAQL 182
            ||:....|||..:|:|.:.|.:.:|..||..::..|:..||...|..:|||.|||.: :::...|
pombe   167 VLQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQFKPDPRIGIGLCFWNL-DMKTDAL 230

  Fly   183 SFQI---ALEHNGQCLNAALALAL--VKFE--HNDE--QSYQDGKML--LTAAYKENNKNPDLLS 236
            |...   .|:.....::..:.|..  :.|:  :||.  |:|  ||.|  :..|:|..|.:|...|
pombe   231 SAWTRVQQLDPKNTVVDTYIGLYYYDLAFQNVNNDSFVQNY--GKALQHIQRAFKTRNNDPVASS 293

  Fly   237 ILAGMYYADGNHKLVWSFAGNAIKFTANKHIESRNYFQIAKSYHATGQFESAKKYYLLSAKSAPD 301
            ||....|:..|::.....|.|.|:.:.:..:.:..|:.:.::||..|..|.|...| ..||:|.|
pombe   294 ILERYVYSKKNYEGCIKLAENVIQNSFSSSLIADGYYWMGRAYHQMGNNEKAMASY-QKAKAADD 357

  Fly   302 GYILPLVGVAQMYLHEGELNRSKAFLESFLTSEPDEPVVMDLLAKIYLEYKCPE------KIDKA 360
            .::|..||:.|:.:.:.:|..:|...|............:.:|..::.....|:      .:|:|
pombe   358 RHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCLHASDSKPDLTKARMLLDRA 422

  Fly   361 IEM-----LVKVVESASYHQNTNSWLNLAFAYEQKRLW-----AHGVNAYQKAIDIYLSQGHQIP 415
            ..:     |.:||:|..|             ..|.|||     ...:....:|:|...|....:.
pombe   423 FNLVGSSKLPRVVDSDLY-------------ITQARLWEKEDTKKSLGFLTRALDFLESAHMSVG 474

  Fly   416 IEWLNNLASSQL-MAKMPE------KALNTLDDALSKCRVMNSDNKTTNLLSLQYNRGLVLEELH 473
            .|.|||:|..|. :..:||      ||.:.|.||          |...:|| |.||.....|||.
pombe   475 PELLNNIAVLQYHLGLIPEAHGNIIKAKSVLPDA----------NPELSLL-LDYNLARCEEELG 528

  Fly   474 MFTLAAENYKSITKEYSSYHDCYLRLGVMAIQKNNHTQAIEHLKDILVEDNLNMTARTYMGDCFK 538
            ..::|:|.|.||.:::.|:.|..:|..::.: .|.:.:..:.::.|:..|:.|:..|.:.|
pombe   529 NTSVASEAYVSILEKHPSFIDARIRKCLLQL-SNPNEETFKEIRHIMNADSQNLEVRAFFG---- 588

  Fly   539 GLSLDKFATFNYNMILARQSKFTNTYVSMAMGNFCLEKLQNW-------IAEGN--FRAAR---- 590
                         ..|::|.:   ..|.......|.:.|::|       :..||  .|.||
pombe   589 -------------WYLSKQKR---RPVEDPEVRHCSQTLRHWHDDIYSLVQLGNAYMRQAREFRV 637

  Fly   591 -------KQQE---KALQCFGKILDCNPKNLWAANGIGAVLSSCNNLSAGGAIFKQIIECGNKCI 645
                   |:|:   ||:|.:.:.:..:|||..||.||..:|:.....|....|..::.| ..|..
pombe   638 HNDREKLKRQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVRE-AIKDA 701

  Fly   646 PAIINSAHIALVSGQYRLAIQTYERCLKDHLPKNRVDVMHCLAKALYDNGDARKAKMWLLK-VRH 709
            ..:||..:......|:..||:.:|.........:...|:.||.:.....|...|...:|.: ||:
pombe   702 TTLINIGNCLAELKQFSRAIEVFETVYSSTGESDTYGVLSCLGRVWLQRGRESKNVDYLKESVRY 766

  Fly   710 LV------PHDPFVIFNLGLA-------IKKETEQALALPRPQLDELMGLDGLLKVAFKLFCHIN 761
            ..      |.:|.::||:...       |:::.|.:..:..... .:..||..::...||   ::
pombe   767 ATLALEKNPENPSLLFNVAFVQFQLCELIRQKPENSRTVEDLNF-AMQQLDASIETFTKL---VS 827

  Fly   762 LNHPKISVRVSAKYAEDCQNLMTELIAKKRQA------SESHAMEEDRVQLQKQRYRDHIEHQRQ 820
            :.||..|.....:.|:..:|.....:.:..||      |.:..:|:.|:|.:|::.|...|.:..
pombe   828 VEHPPYSPTSIEQRAKMAKNTTKRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEAL 892

  Fly   821 QELQREEEERVRRENLKIQRKEVLERTRKIISA-----PLAPDVPKKSAGNGRAKK--------- 871
            .:.::|.|.:::.|..|:| :||||..:....|     .|:.|..|:|   |:.||
pombe   893 LKEKQERERQLQEERQKMQ-EEVLEWRKSQQKASEDDMSLSDDEEKQS---GKKKKKDRKKRKSK 953

  Fly   872 -NQENGD-GKAKKSGPP----KKKTRKR------------------AAGKEQEDI-EPLKKPKSK 911
             .||:.| |.::....|    :.||:||                  |.|.::|:: ..:::.:..
pombe   954 SKQESSDSGVSEDDEIPLSDARNKTKKRRVNRRVISEEYTFDQDSDAEGNQEEEVSRTIEEKQDN 1018

  Fly   912 EFIDTDDDNSE 922
            :..|..|||.|
pombe  1019 DITDNQDDNKE 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9899	NP_611764.1	TPR_11	125..191	CDD:290150	22/68 (32%)
		TPR repeat	125..155	CDD:276809	10/29 (34%)
		TPR repeat	161..189	CDD:276809	9/30 (30%)
		TPR	174..443	CDD:223533	70/302 (23%)
		TPR repeat	272..297	CDD:276809	7/24 (29%)
		PEP_TPR_lipo	275..>735	CDD:274350	117/519 (23%)
		TPR repeat	303..333	CDD:276809	7/29 (24%)
		TPR repeat	338..369	CDD:276809	6/41 (15%)
		TPR repeat	376..406	CDD:276809	5/34 (15%)
		TPR repeat	416..444	CDD:276809	13/34 (38%)
		TPR repeat	458..488	CDD:276809	13/29 (45%)
		TPR repeat	493..520	CDD:276809	3/26 (12%)
		TPR repeat	580..605	CDD:276809	11/47 (23%)
		TPR repeat	610..640	CDD:276809	8/29 (28%)
		TPR repeat	645..673	CDD:276809	6/27 (22%)
		TPR repeat	680..710	CDD:276809	8/30 (27%)
tpr1	NP_594620.1	TPR_11	174..241	CDD:290150	22/67 (33%)
		TPR repeat	178..203	CDD:276809	6/24 (25%)
		TPR repeat	208..239	CDD:276809	9/31 (29%)
		TPR repeat	244..283	CDD:276809	10/40 (25%)
		tol_pal_ybgF	299..389	CDD:188247	23/90 (26%)
		TPR_8	326..356	CDD:289924	9/30 (30%)
		TPR repeat	326..354	CDD:276809	8/28 (29%)
		TPR repeat	359..389	CDD:276809	7/29 (24%)
		TPR repeat	394..422	CDD:276809	3/27 (11%)
		TPR_12	664..729	CDD:290160	18/65 (28%)
		TPR repeat	667..696	CDD:276809	8/28 (29%)
		TPR repeat	701..729	CDD:276809	6/27 (22%)
		TPR repeat	736..773	CDD:276809	8/36 (22%)
		TrbI	793..>916	CDD:305006	27/127 (21%)
		COX16	<875..916	CDD:290843	12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	98	1.000	Domainoid score	I1877
eggNOG	1	0.900	-	-		E2759_KOG2002
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I732
OMA	1	1.010	-	-		QHG54530
OrthoFinder	1	1.000	-	-		FOG0003745
OrthoInspector	1	1.000	-	-		otm47271
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.930