DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp59D and Kif2a

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_445828.1	Gene:	Kif2a / 84391	RGDID:	70974	Length:	705	Species:	Rattus norvegicus

Alignment Length:	736	Identity:	324/736 - (44%)
Similarity:	441/736 - (59%)	Gaps:	72/736 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RIKIGEQLLFQRSDGRVHQVVCTAKNLERDSITGEWTEGTVVKGKEVPLSTLIGINHHIFAENQP 67
            :|:||..:..:|||||:||.:.|:.|.:.:|:|.||.|....||||:.|.::..:|
  Rat     8 KIQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLESIFSLN--------- 63

  Fly    68 PISKPPSSLLPKPRGSSPTGGPKTHTGNPYAERMRVQDGRSKIATRKTDPAAVGAGNHELGRAHT 132
            |...|...:.|.|....|:...|.:         ::...|..:|:.|.||..  ..|..:|.|..
  Rat    64 PDLVPDEDIEPSPEIPPPSSSSKVN---------KIVKNRRTVASIKNDPPP--RDNRVVGSARA 117

  Fly   133 PRVPAGRPDR-----------DASPTQGRKSQGGNNSNQRFSSVVREVNRMKEQREKRRARQAEQ 186
            .  |:..|::           |.||.|..|.:.|..| :|.|:.|:||.:::|:|||||.:| ::
  Rat   118 R--PSQLPEQSSSAQQNGSVSDISPVQAAKKEFGPPS-RRKSNCVKEVEKLQEKREKRRLQQ-QE 178

  Fly   187 LQEKDALRRNNPGNPNWEVSVMLRQYRSTLIFSPLRCLDPNGGTVQQITVCVRKRPMSRKEENSK 251
            |:||.| :..:..|||:|:..|:|.:|.:|.:.||...||.  ...:|.|||||||:::||...|
  Rat   179 LREKRA-QDVDATNPNYEIMCMIRDFRGSLDYRPLTTADPI--DEHRICVCVRKRPLNKKETQMK 240

  Fly   252 NLDIITVPSADSLIVHELRLKVDLTKFLEHHKFRFDYTFDEECSNALVYDHTARPLIRTMFEGGN 316
            :||:||:||.|.::|||.:.|||||::||:..|||||.||:...|.:||..|||||:.|:||.|.
  Rat   241 DLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGM 305

  Fly   317 ATCFAYGQTGSGKTHTMGGEFFGKVQDCGTGIYAMAARDVFEEVSRPEYRQMGAKITCSFFEIYG 381
            |||||||||||||||||||:|.||.|||..||||:||||||..:.:|.|:::..::..:|||||.
  Rat   306 ATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYS 370

  Fly   382 TKVFDLLLPNKPMLRVLEDARQQVVVVGLTEMPVTKVEDVLRLIEHGSKERTSGQTSANAKSSRS 446
            .|||| ||..|..||||||.:|||.||||.|..|..|||||:||:.|:..||||||||||.||||
  Rat   371 GKVFD-LLNRKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRS 434

  Fly   447 HAVFQIALHFPDSWGPHGKCSFVDLAGNERGADTQSADRQTRIEGAEINKSLLALKECIRALSRQ 511
            ||||||.|......  |||.|.:|||||||||||.|||||||:|||||||||||||||||||.|.
  Rat   435 HAVFQIILRRKGKL--HGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRN 497

  Fly   512 SSHLPFRGSKLTQVLRDSFVGGKKNKTCMIAMISPSMSCVENTLNTLRYADRVKELIAKEDEHLQ 576
            ..|.|||.|||||||||||: |:.::|||||.|||.|:..||||||||||:|||||..
  Rat   498 KPHTPFRASKLTQVLRDSFI-GENSRTCMIATISPGMASCENTLNTLRYANRVKELTV------- 554

  Fly   577 SVEGDGEKSPDLNEESEPEMMADEEGD----EEPEDEDNQHLTISSEEASSYNNMSYDMSFNHTL 637
            .....|:..|.::.  .|..:.|.|..    ..|:.:|.:.|...:||..|....::..:.
  Rat   555 DPTAAGDVRPIMHH--PPSQIDDLETQWGVGSSPQRDDLKLLCEQNEEEVSPQLFTFHEAV---- 613

  Fly   638 NILGPSRNVDIQE-VAEQHALLVENLETYAHNFRQL-----KTDKEIEQYTQNSESALMKLLAMV 696
                 |:.|:::| |.|.|..:.:....:..:.:.|     :.|.:::.|....|:.|.:.:.::
  Rat   614 -----SQMVEMEEQVVEDHRAVFQESIRWIEDEKALLEMTEEVDYDVDSYATQLEAILEQKIDIL 673

  Fly   697 NRTRDVTHNYNTQKLLKEENQ 717
            ...||...::  :..|:||.|
  Rat   674 TELRDKVKSF--RAALQEEEQ 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	218/331 (66%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	215/326 (66%)
Kif2a	NP_445828.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..185		38/135 (28%)
Kif2a	NP_445828.1	KISc_KIF2_like	222..550	CDD:276818	218/331 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020