DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59D and KINESIN-13A

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_188285.1	Gene:	KINESIN-13A / 820915	AraportID:	AT3G16630	Length:	794	Species:	Arabidopsis thaliana

Alignment Length:	611	Identity:	232/611 - (37%)
Similarity:	301/611 - (49%)	Gaps:	133/611 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 RQYRSTLIFSPLRCL---DPNGGTVQQITVCVRKRPMSRKEENSKNLDIITVPSADSLIVHELRL 271
            ||.|......||..|   |....:|.:|.|.|||||:::||...|..|::|| |.:||.|||.|:
plant   167 RQQRQQTEAEPLGLLPKSDKENNSVAKIKVVVRKRPLNKKETAKKEEDVVTV-SDNSLTVHEPRV 230

  Fly   272 KVDLTKFLEHHKFRFDYTFDEECSNALVYDHTARPLIRTMFEGGNATCFAYGQTGSGKTHTMGGE 336
            |||||.::|.|:|.||...||:.||..||..|..|:|..:|:...||||||||||||||.||
plant   231 KVDLTAYVEKHEFCFDAVLDEDVSNDEVYRATIEPIIPIIFQRTKATCFAYGQTGSGKTFTM--- 292

  Fly   337 FFGKVQDCGTGIYAMAARDVFEEVSRPEYRQMGAKITCSFFEIYGTKVFDLLLPNKPMLRVLEDA 401
                     ..:...|..|:...:.:|.|.....|:..|:|||||.|:||||...| .|.:.||.
plant   293 ---------KPLPIRAVEDLMRLLRQPVYSNQRFKLWLSYFEIYGGKLFDLLSERK-KLCMREDG 347

  Fly   402 RQQVVVVGLTEMPVTKVEDVLRLIEHGSKERTSGQTSANAKSSRSHAVFQIALHFPDSWGPH--- 463
            ||||.:|||.|..|:.|:.|...||.|:.||::|.|.||.:||||||:.|:.:.      .|
plant   348 RQQVCIVGLQEYEVSDVQIVKDFIEKGNAERSTGSTGANEESSRSHAILQLVVK------KHVEV 406

  Fly   464 ------------------GKCSFVDLAGNERGADTQSADRQTRIEGAEINKSLLALKECIRALSR 510
                              ||.||:||||:||||||...|||||||||||||||||||||||||..
plant   407 KDTRRRNNDSNELPGKVVGKISFIDLAGSERGADTTDNDRQTRIEGAEINKSLLALKECIRALDN 471

  Fly   511 QSSHLPFRGSKLTQVLRDSFVGGKKNKTCMIAMISPSMSCVENTLNTLRYADRVKELI----AKE 571
            ...|:||||||||:||||||||  .::|.||:.|||:....|:||||||||||||.|.    :|:
plant   472 DQLHIPFRGSKLTEVLRDSFVG--NSRTVMISCISPNAGSCEHTLNTLRYADRVKSLSKSGNSKK 534

  Fly   572 DEHLQS---VEGDGEKSP-DLNEESEP--EMMADEEGDEEPEDEDNQHL---------------- 614
            |:...|   |..|....| |:.:..||  |:...|......|.:.|...
plant   535 DQTANSMPPVNKDPLLGPNDVEDVFEPPQEVNVPETRRRVVEKDSNSSTSGIDFRQPTNYREESG 599

  Fly   615 --TISSEEASSYNNMSYDMSFNHTLNI----------------LGPSRNVDIQE----------- 650
              :.|.::..|..|.|:..|.:...||                :.|.|...::|
plant   600 IPSFSMDKGRSEPNSSFAGSTSQRNNISSYPQETSDREEKVKKVSPPRGKGLREEKPDRPQNWSK 664

  Fly   651 --VAEQHALLVENL-----ETYAHNF----RQLKTDKEIEQYTQ---NSESAL------------ 689
              |:......:.|.     ||.:..:    ||.:||..:::...   ..|.||
plant   665 RDVSSSDIPTLTNFRQNASETASRQYETASRQYETDPSLDENLDALLEEEEALIAAHRKEIEDTM 729

  Fly   690 ------MKLLAMVNRTRDVTHNYNTQ 709
                  |||||.|::...:..||.||
plant   730 EIVREEMKLLAEVDQPGSMIENYVTQ 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	177/352 (50%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	175/347 (50%)
KINESIN-13A	NP_188285.1	SAM_superfamily	29..84	CDD:417767
KINESIN-13A	NP_188285.1	KISc_KIF2_like	193..524	CDD:276818	177/352 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	319	1.000	Domainoid score	I283
eggNOG	1	0.900	-	-		E2759_KOG0246
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I681
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D418348at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1030
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.830