DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59D and kif2c

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001006856.1	Gene:	kif2c / 448620	XenbaseID:	XB-GENE-961445	Length:	734	Species:	Xenopus tropicalis

Alignment Length:	784	Identity:	320/784 - (40%)
Similarity:	431/784 - (54%)	Gaps:	130/784 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RIKIGEQLLFQRSDGRVHQVVCTAKNLERDSITGEWTEGTVVKGKEVPLSTLIGINHHIF----- 62
            |:..|..:...||:|.:|....|:.|::|.|:..||.||...||||:..:.:|.:|..:.
Frog     8 RLVTGLVVKIMRSNGVIHNASITSVNMDRSSVNVEWKEGDANKGKEISFADVISVNPELLDAVLA 72

  Fly    63 ----AENQPP-------------ISKPP--------SSLLPKPRGSS-----PTGGPKTHTGNPY 97
                .||.||             |||.|        :||||:....|     .|.....|...|.
Frog    73 PPNVKENMPPQRNVPSQNQKRKTISKIPAPKEVTTQNSLLPEYGAQSVLRERSTRMTAIHEALPS 137

  Fly    98 AERMRV------------QDGRSKIATRKTDPAAVGAGNHELGRAHTPRVPAGRPDRDASPTQGR 150
            ...|.|            |.|||    |.|..:..|    ||  ...||: :...:....|.:
Frog   138 ENEMEVESTVLPVQQNSIQVGRS----RSTKASVAG----EL--RSQPRI-SEIVEESLPPVR-- 189

  Fly   151 KSQGGNNSNQRFSSVVREVNRMKEQREKRRARQAE----QLQEKDALRRNNPGNPNWEVSVMLRQ 211
                 ||..:|.|::|:|:.:||.:||::||:.:|    :.|:.|.      ..||||...|::.
Frog   190 -----NNQARRKSNIVKEMEKMKNKREEQRAQNSELRIKRAQDYDT------SIPNWEFGKMIKD 243

  Fly   212 YRSTLIFSPLRCLDPNGGTVQQITVCVRKRPMSRKEENSKNLDIITVPSADSLIVHELRLKVDLT 276
            :|:|:....:...||  ....:|.|||||||::::|.:.|.:|||:|||.:.::|||.:||||||
Frog   244 FRATMDCHRISMADP--AEEHRICVCVRKRPLNKQELSKKEIDIISVPSKNIVLVHEPKLKVDLT 306

  Fly   277 KFLEHHKFRFDYTFDEECSNALVYDHTARPLIRTMFEGGNATCFAYGQTGSGKTHTMGGEFFGKV 341
            |:||:..|||||:|||..:|.:||..|||||::::||||.|||||||||||||||||||:|.||.
Frog   307 KYLENQPFRFDYSFDETATNEVVYRFTARPLVQSIFEGGKATCFAYGQTGSGKTHTMGGDFSGKS 371

  Fly   342 QDCGTGIYAMAARDVFEEVSRPEYRQMGAKITCSFFEIYGTKVFDLLLPNKPMLRVLEDARQQVV 406
            |:...|:||.|:||||..:.:|.|:.:...:..:|||||..|||| ||..|..|||||||:|:|.
Frog   372 QNVSKGVYAFASRDVFLLLDQPRYKHLDLDVFVTFFEIYNGKVFD-LLNKKAKLRVLEDAKQEVQ 435

  Fly   407 VVGLTEMPVTKVEDVLRLIEHGSKERTSGQTSANAKSSRSHAVFQIALHFPDSWGPHGKCSFVDL 471
            ||||.|..||..:||.::||.||..||||||.||:.||||||..||.|......  |||.|.|||
Frog   436 VVGLLERQVTSADDVFKMIEVGSACRTSGQTFANSSSSRSHACLQIILRRGSKL--HGKFSLVDL 498

  Fly   472 AGNERGADTQSADRQTRIEGAEINKSLLALKECIRALSRQSSHLPFRGSKLTQVLRDSFVGGKKN 536
            |||||||||.||||.||:||||||:||||||||||||.:..||.|||.|||||:|||||: |:.:
Frog   499 AGNERGADTASADRITRMEGAEINRSLLALKECIRALGQNKSHTPFRESKLTQILRDSFI-GENS 562

  Fly   537 KTCMIAMISPSMSCVENTLNTLRYADRVKELIAKEDEHLQSVEGDGEKSPDLNEESEPEMMADEE 601
            :||||||:||..:..|.||||||||||||||                 ||. |.|:.     |:.
Frog   563 RTCMIAMLSPGFNSCEYTLNTLRYADRVKEL-----------------SPQ-NAETN-----DDN 604

  Fly   602 GDEEPEDEDNQHLTI-----------SSEEASSYNNMSYDMSFNHTLNILGPSRNVDIQEVAEQH 655
            ...|.||.|..|.:|           ..||.|::.|     ||...||.:|......::|:.|
Frog   605 LQMETEDSDGSHASIGGLQLQDDFLLKDEELSTHIN-----SFQDALNRVGELEEKAVEELRE-- 662

  Fly   656 ALLVENLETYAHNFRQL--KTDKEIEQYTQNSESALMKLLAMVNRTRDVTHNYNTQKLLKEENQN 718
              ||:. |....|..|.  :.|.::|.:...:|..:.:...::....|   :.|:.:|..:..:.
Frog   663 --LVQR-EPEWTNLLQTTEQPDYDLENFVIQAEYLIQERSKVLISLGD---SINSLRLALQVEEQ 721

  Fly   719 AYKK 722
            |.|:
Frog   722 ASKQ 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	207/331 (63%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	204/326 (63%)
kif2c	NP_001006856.1	KISc_KIF2_like	263..591	CDD:276818	207/331 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.110