DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59D and Klp67A

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	152/540 - (28%)
Similarity:	250/540 - (46%)	Gaps:	87/540 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 ITVCVRKRPMSRKEENSKNLDIITVPSADSLIV---------------HELRLKVDLTKFLEHH- 282
            |.|.||.||.:.:|...|...||.|....:|:.               ...|   |:||.:...
  Fly     9 IKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYR---DITKRMNKKL 70

  Fly   283 KFRFDYTFDEECSNALVYDHTARPLIRTMFEGGNATCFAYGQTGSGKTHTMGGEFFGKVQDCGTG 347
            ...||..||.:.||..:::....||:..:..|.|.:.|.||.||:|||.||.|      .:...|
  Fly    71 TMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLG------SEAHPG 129

  Fly   348 IYAMAARDVFEEV-SRPEYRQMGAKITCSFFEIYGTKVFDLLLPNKPMLRVLEDARQQVVVVGLT 411
            :..:..:|:|::: ::.:.|:....:  |:.|:|...|.:||..:.| |::.|| ...|||.||.
  Fly   130 LTYLTMQDLFDKIQAQSDVRKFDVGV--SYLEVYNEHVMNLLTKSGP-LKLRED-NNGVVVSGLC 190

  Fly   412 EMPVTKVEDVLRLIEHGSKERTSGQTSANAKSSRSHAVFQIALHFPD---SWGPHGKCSFVDLAG 473
            ..|:...|::||::..|:..||...|.|||:||||||:||:.:...:   ......|.|.:||||
  Fly   191 LTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKRTVKLSMIDLAG 255

  Fly   474 NERGADTQSADRQTRIEGAEINKSLLALKECIRALSRQSSHLPFRGSKLTQVLRDSFVGGKKNKT 538
            :||.|.|:....:.: |||.||||||||..||..|:....|:|:|.|.||::|:||.  |...:|
  Fly   256 SERAASTKGIGVRFK-EGASINKSLLALGNCINKLADGLKHIPYRDSNLTRILKDSL--GGNCRT 317

  Fly   539 CMIAMISPSMSCVENTLNTLRYADRVKEL------------------IAKEDEHLQSVEGDGEKS 585
            .|:|.:|.|....|:|.|||:||.|.|::                  :.|.||    |..:.|:.
  Fly   318 LMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDE----VVAENERL 378

  Fly   586 PDLNEESEPEMMADEEGDE---EPEDEDNQHLTISSEEASSYNNMSYDMSFNHTLNILGPSRNVD 647
            .:.|:..|.:....|....   :|.:....:..|.:..|::....      .|.|.:....:|::
  Fly   379 KERNKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQ------EHVLGMRSKIKNIN 437

  Fly   648 I-----QEVAEQHALLVENLETYAHNFRQLKT-----DKEIEQYTQNSESALMKLLAMVNRTRDV 702
            .     :|:.|...|:..:......:||:...     ..::|:|.:...|.|.|:        ::
  Fly   438 YRQTLKKELEEFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSWLSKM--------EI 494

  Fly   703 THNYNTQKLLKEENQN-AYK 721
            .:. :.:.|.:|.|:: ||:
  Fly   495 AYQ-DLESLKREVNKSKAYQ 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	122/350 (35%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	119/346 (34%)
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	123/359 (34%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	123/352 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940