DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp59D and KIF2A

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001091981.1	Gene:	KIF2A / 3796	HGNCID:	6318	Length:	744	Species:	Homo sapiens

Alignment Length:	768	Identity:	331/768 - (43%)
Similarity:	450/768 - (58%)	Gaps:	97/768 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RIKIGEQLLFQRSDGRVHQVVCTAKNLERDSITGEWTEGTVVKGKEVPLSTLIGINHHIFAENQP 67
            :|:||..:..:|||||:||.:.|:.|.:.:|:|.||.|....||||:.|.::..:|..:.    |
Human     8 KIQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLV----P 68

  Fly    68 PISKPPSSLLPKPRGSSPTGGPKTHTGNPYAERMRVQDGRSKIATRKTDPAAVGAGNHELGRAHT 132
            .....||...|.|..||             |:..::...|..:|:.|.||.:  ..|..:|.|..
Human    69 DEEIEPSPETPPPPASS-------------AKVNKIVKNRRTVASIKNDPPS--RDNRVVGSARA 118

  Fly   133 PRVPAGRPDR-----------DASPTQGRKSQGGNNSNQRFSSVVREVNRMKEQREKRRARQAEQ 186
            .  |:..|::           |.||.|..|.:.|..| :|.|:.|:||.:::|:|||||.:| ::
Human   119 R--PSQFPEQSSSAQQNGSVSDISPVQAAKKEFGPPS-RRKSNCVKEVEKLQEKREKRRLQQ-QE 179

  Fly   187 LQEKDALRRNNPGNPNWEVSVMLRQYRSTLIFSPLRCLDPNGGTVQQITVCVRKRPMSRKEENSK 251
            |:||.| :..:..|||:|:..|:|.:|.:|.:.||...||.  ...:|.|||||||:::||...|
Human   180 LREKRA-QDVDATNPNYEIMCMIRDFRGSLDYRPLTTADPI--DEHRICVCVRKRPLNKKETQMK 241

  Fly   252 NLDIITVPSADSLIVHELRLKVDLTKFLEHHKFRFDYTFDEECSNALVYDHTARPLIRTMFEGGN 316
            :||:||:||.|.::|||.:.|||||::||:..|||||.||:...|.:||..|||||:.|:||.|.
Human   242 DLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGM 306

  Fly   317 ATCFAYGQTGSGKTHTMGGEFFGKVQDCGTGIYAMAARDVFEEVSRPEYRQMGAKITCSFFEIYG 381
            |||||||||||||||||||:|.||.|||..||||:||||||..:.:|.|:::..::..:|||||.
Human   307 ATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYS 371

  Fly   382 TKVFDLLLPNKPMLRVLEDARQQVVVVGLTEMPVTKVEDVLRLIEHGSKERTSGQTSANAKSSRS 446
            .|||| ||..|..||||||.:|||.||||.|..|..|||||:||:.|:..||||||||||.||||
Human   372 GKVFD-LLNRKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRS 435

  Fly   447 HAVFQIALHFPDSWGPHGKCSFVDLAGNERGADTQSADRQTRIEGAEINKSLLALKECIRALSRQ 511
            ||||||.|......  |||.|.:|||||||||||.|||||||:|||||||||||||||||||.|.
Human   436 HAVFQIILRRKGKL--HGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRN 498

  Fly   512 SSHLPFRGSKLTQVLRDSFVGGKKNKTCMIAMISPSMSCVENTLNTLRYADRVKEL-IAKEDEHL 575
            ..|.|||.|||||||||||: |:.::|||||.|||.|:..||||||||||:||||. |:..|  :
Human   499 KPHTPFRASKLTQVLRDSFI-GENSRTCMIATISPGMASCENTLNTLRYANRVKEFGISPSD--I 560

  Fly   576 QSVEGDGEKSPDLNEESE-------------------------------PEMMADEEGD----EE 605
            ...:|.|.: |||:...|                               |..:.|.|..    ..
Human   561 PFSQGSGSR-PDLSPSYEYDDFSPSVTRVKELTVDPTAAGDVRPIMHHPPNQIDDLETQWGVGSS 624

  Fly   606 PEDEDNQHLTISSEEASSYNNMSYDMSFNHTLNILGPSRNVDIQE-VAEQHALLVENLETYAHNF 669
            |:.:|.:.|...:||..|....::..:.         |:.|:::| |.|.|..:.:....:..:.
Human   625 PQRDDLKLLCEQNEEEVSPQLFTFHEAV---------SQMVEMEEQVVEDHRAVFQESIRWLEDE 680

  Fly   670 RQL-----KTDKEIEQYTQNSESALMKLLAMVNRTRDVTHNYNTQKLLKEENQ 717
            :.|     :.|.:::.|....|:.|.:.:.::...||...::  :..|:||.|
Human   681 KALLEMTEEVDYDVDSYATQLEAILEQKIDILTELRDKVKSF--RAALQEEEQ 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	218/331 (66%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	215/326 (66%)
KIF2A	NP_001091981.1	KISc	223..559	CDD:214526	222/339 (65%)
KIF2A	NP_001091981.1	KISc_KIF2_like	223..551	CDD:276818	218/331 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0246
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2059
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.830