DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp59D and Klp59C

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	597	Identity:	301/597 - (50%)
Similarity:	374/597 - (62%)	Gaps:	70/597 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDRIKIGEQLLFQRSDGRVHQV-VCTAKNLERDSITGEWTEGTVVKGKEVPLSTLIGINHHIFAE 64
            ||::.|.:::..:|||||||.. :...:..:...||.||.||..|:|||:||..::.:|.|||..
  Fly     1 MDKLSIEQKIFIRRSDGRVHLAEIIKLEGGDSKLITVEWPEGHTVRGKELPLELVVLMNPHIFDS 65

  Fly    65 NQPPISKPPSSLLPKPRGSSPTGGPKTHTGNPYAERMRVQDGRSKIATRKTDPAAVGAGNHELGR 129
                         |:..|.:.....:|.:.:|.:.:.|       |||....|....|
  Fly    66 -------------PRCSGGNAASANQTASISPRSMKQR-------IATGSLSPVLATA------- 103

  Fly   130 AHTPRVPAGRPDRDASPTQGRKSQGGNNSNQRFSSVVREVNRMKEQREKRRARQAEQLQEKDALR 194
              .||.....|.|:                   ..||.:..||:::||:||..||....:::..:
  Fly   104 --PPRQQTAPPVRE-------------------DEVVHQAERMRKERERRREAQARTRLDREQGK 147

  Fly   195 RNNPGNPNWEVSVMLRQYRSTLIFSPLRCLDPNGGTV------QQITVCVRKRPMSRKEENSKNL 253
            ..:||||||||:.|:|..|..:....:|     .||.      .||.|||||||:.|||...:..
  Fly   148 NEDPGNPNWEVARMIRLQREQMESQRVR-----SGTTNERINCHQIMVCVRKRPLRRKELADREQ 207

  Fly   254 DIITVPSADSLIVHELRLKVDLTKFLEHHKFRFDYTFDEECSNALVYDHTARPLIRTMFEGGNAT 318
            |::::||..:|:|||.|..|:|.||||:|.|||||.||||||||.||:.||||||:.:|:||.||
  Fly   208 DVVSIPSKHTLVVHEPRKHVNLVKFLENHSFRFDYVFDEECSNATVYEFTARPLIKHIFDGGMAT 272

  Fly   319 CFAYGQTGSGKTHTMGGEFFGKVQDCGTGIYAMAARDVFEEVSRPEYRQMGAKITCSFFEIYGTK 383
            ||||||||||||:||||:|.|:.|....|||||||:|||..:....|.::..|:.|||||||||:
  Fly   273 CFAYGQTGSGKTYTMGGQFPGRHQSSMDGIYAMAAKDVFSTLKTVPYNKLNLKVYCSFFEIYGTR 337

  Fly   384 VFDLLLPNKPMLRVLEDARQQVVVVGLTEMPVTKVEDVLRLIEHGSKERTSGQTSANAKSSRSHA 448
            |||||:|.||.||||||..|||.|||||:.||....:||.|:|.|:..||||.||||:|||||||
  Fly   338 VFDLLMPGKPQLRVLEDRNQQVQVVGLTQNPVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHA 402

  Fly   449 VFQIALHFPDSWGPHGKCSFVDLAGNERGADTQSADRQTRIEGAEINKSLLALKECIRALSRQSS 513
            ||||.|........|||.|.:||||||||||..|||||||:||:|||||||.||||||||.||||
  Fly   403 VFQIVLRSAAGEKLHGKFSLIDLAGNERGADNSSADRQTRLEGSEINKSLLVLKECIRALGRQSS 467

  Fly   514 HLPFRGSKLTQVLRDSFVGGKKNKTCMIAMISPSMSCVENTLNTLRYADRVKELIAKEDEHLQSV 578
            |||||||||||||||||:||||.||||||||||.:..||:||||||||||||||         ||
  Fly   468 HLPFRGSKLTQVLRDSFIGGKKVKTCMIAMISPCLHSVEHTLNTLRYADRVKEL---------SV 523

  Fly   579 EG-DGEKSPDLN 589
            |. ..::.||.|
  Fly   524 ESIPSKRMPDAN 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	227/331 (69%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	223/326 (68%)
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	227/331 (69%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	223/326 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438274
Domainoid	1	1.000	319	1.000	Domainoid score	I283
eggNOG	1	0.900	-	-		E2759_KOG0246
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I681
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	1	1.000	-	-		mtm1030
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X866
	10	9.900