DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59D and Khc

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	160/537 - (29%)
Similarity:	244/537 - (45%)	Gaps:	72/537 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 ITVCVRKRPMSRKEENSKNLDIITVPSADSLIVHELRLKVDLTKFLEHHKFRFDYTFDEECSNAL 298
            |.|..|.||::..||.:.:..::..|:.    |.|..:.:....:|      ||..|....|...
  Fly    13 IKVVCRFRPLNDSEEKAGSKFVVKFPNN----VEENCISIAGKVYL------FDKVFKPNASQEK 67

  Fly   299 VYDHTARPLIRTMFEGGNATCFAYGQTGSGKTHTMGGEFFGKVQDCGTGIYAMAARDVFEEVSRP 363
            ||:..|:.::..:..|.|.|.||||||.|||||||.|.....|:.   ||......|:|..:...
  Fly    68 VYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQ---GIIPRIVNDIFNHIYAM 129

  Fly   364 EYRQMGAKITCSFFEIYGTKVFDLLLPNKPMLRVLEDARQQVVVVGLTEMPVTKVEDVLRLIEHG 428
            |. .:...|..|::|||..|:.|||..:|..|.|.||..:...|.|.||..|:..|||..:||.|
  Fly   130 EV-NLEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEG 193

  Fly   429 SKERTSGQTSANAKSSRSHAVFQIAL---HFPDSWGPHGKCSFVDLAGNERGADTQSADRQTRIE 490
            ...|....|:.|..|||||:||.|.:   :..:.....||...|||||:|:.:.| .|:.....|
  Fly   194 KSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKT-GAEGTVLDE 257

  Fly   491 GAEINKSLLALKECIRALS-RQSSHLPFRGSKLTQVLRDSFVGGKKNKTCMIAMISPSMSCVENT 554
            ...|||||.||...|.||: ...:|:|:|.||||::|::| :||.. :|.::...||:......|
  Fly   258 AKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQES-LGGNA-RTTIVICCSPASFNESET 320

  Fly   555 LNTLRYADRVK----------ELIAKEDEHLQSVEGDGEKSPDLN---EESEPEM---------M 597
            .:||.:..|.|          ||.|  :|..:..|.:.||:..|.   |:.|.|:         .
  Fly   321 KSTLDFGRRAKTVKNVVCVNEELTA--EEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVK 383

  Fly   598 ADEEGDEE-------PEDEDNQHLTISSEEA-----SSYNNMSYDMSFNHTLNILGPSRNV---- 646
            |:|:.:.|       |..|.....|.::|.|     ::..|||..::.|....:......:
  Fly   384 AEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQL 448

  Fly   647 -DIQEVAEQHALLVENL--------ETYAHNFRQLKT-DKEIEQYTQNSESALMKLLAMVNRTRD 701
             |..|...|.:...|.|        |..|:..|:.:| ..|:.:..|.:|||..::..::....:
  Fly   449 DDKDEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEE 513

  Fly   702 VTHNYNTQKLLKEENQN 718
            :..||: ||..:.:|:|
  Fly   514 LAVNYD-QKSQEIDNKN 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	116/334 (35%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	115/340 (34%)
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	117/336 (35%)
		KISc	12..340	CDD:214526	117/343 (34%)
		Apolipoprotein	595..744	CDD:279749
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437821
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940