DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp59D and cos

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	126/563 - (22%)
Similarity:	188/563 - (33%)	Gaps:	170/563 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 DPNGGTVQQITV-----------------------CVRKRPMSRKEENSKNLDIITVPSA----- 261
            ||||...|....                       ||:..|:|        ...:.:|||
  Fly    63 DPNGNAEQDSAADSKTIPDANGNDSGQKDYPDSAYCVQAIPIS--------ASALGLPSALPGGD 119

  Fly   262 --DSLIVHELRLKVDLTKFLEHHKFRFDYTFDEECSNALVYDHTARPLIRTMFEGGNATCFAYGQ 324
              ||:....::        :..|.....:......|...||..|..|||....||.:|:...|||
  Fly   120 PMDSIAAGLIQ--------VGPHTVPVTHALPSSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQ 176

  Fly   325 TGSGKTHTMGGEFFGKVQ-----DCGTGIYAMAARDVFEEVS-RPEYRQMGAKITCSFFEIYGTK 383
            .|.||::|:    :|.||     |...|:..:..||:|..:| .||...   .|...|.||.|..
  Fly   177 RGQGKSYTL----YGNVQDPTLTDSTEGVVQLCVRDIFSHISLHPERTY---AINVGFVEICGGD 234

  Fly   384 VFDLLLPNKPMLRVLEDARQQVVVVGLTEMPVTKVEDVLRLIEHGSKERTSGQTSANAKSSRSHA 448
            |.|||                    |:..:..|.|:.|...::.|...|         :|..:|.
  Fly   235 VCDLL--------------------GMGNIHCTNVDAVFHWLQVGLSAR---------QSLPAHT 270

  Fly   449 VFQIALHFPDSW-GPHG-------KCSFVDLAGNERGADTQSADRQTRIEGAEINKSLLALKECI 505
            :|.:.|.  ..| ...|       ..||.||.|.||..|        :..|..::..|..|::.|
  Fly   271 LFTLTLE--QQWVSKEGLLQHRLSTASFSDLCGTERCGD--------QPPGRPLDAGLCMLEQVI 325

  Fly   506 RALSRQ------SSHLPFRGSKLTQVLRDSFVGGKKNKTCMIAMISPSMSCVENTLNTLRYADRV 564
            ..|:..      :.::|:..:.||.:|:|||  |.:.:|.:|..:||....:..||..|::|.:|
  Fly   326 STLTDPGLMYGVNGNIPYGQTTLTTLLKDSF--GGRAQTLVILCVSPLEEHLPETLGNLQFAFKV 388

  Fly   565 KELIAKEDEHLQSVEGDGEKSPDLNEESEPEMMADEEGDEEPEDEDNQHLTISSEEASSYNNMSY 629
                       |.|    .....:|..|:...|..:..:..||         |:..|.
  Fly   389 -----------QCV----RNFVIMNTYSDDNTMIVQPAEPVPE---------SNSSAG------- 422

  Fly   630 DMSFNHTLNILGPSRNVDIQEVAEQHALLVENLETYAHNFRQLKTDKEIEQ--------YTQNSE 686
                  .|:..||..|..:|..|.|.:.||.|.|.........|...|:|:        ..|..|
  Fly   423 ------PLSQAGPGDNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIEEWLFLKQECE 481

  Fly   687 SALMKLLAM-----------VNRTRDVTHNYNTQKLLKEENQN 718
            ..|....||           .....||.......:....:|:|
  Fly   482 ECLSSTEAMRQQKQLVPILEAEEPEDVNSEAANSESPNSDNEN 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	88/381 (23%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	87/353 (25%)
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	80/315 (25%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437788
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030