DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59D and Klp31E

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001162935.1	Gene:	Klp31E / 34422	FlyBaseID:	FBgn0032243	Length:	1048	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	167/560 - (29%)
Similarity:	262/560 - (46%)	Gaps:	81/560 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 ITVCVRKRPMSRKEENSKNL-DIITVPSADSLIVHELRLKVDLTKFLEHHKFRFDYTFDEECSNA 297
            :.|.||.||     :||:.| |:..:.:..:|...::.|..|       ..|.|||.||...:..
  Fly    14 VRVAVRIRP-----QNSRELIDMCRICTTVTLGEPQIFLGSD-------KAFTFDYVFDTNSNQC 66

  Fly   298 LVYDHTARPLIRTMFEGGNATCFAYGQTGSGKTHTMGGEFFGKVQDCGT---GIYAMAARDVF-- 357
            .:|......|:.:...|.|||..||||||||||:|||..|..:.:...:   ||...|.|.:|
  Fly    67 DIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVRHIFSG 131

  Fly   358 ----EEVSRPEYRQMGA----KITCSFFEIYGTKVFDLLLP-NK-PMLRVLEDARQQVVVVGLTE 412
                |..|..|:...|.    .:...:.|:|...:||||.| || ...::.|||..|:.:.|.:.
  Fly   132 IEQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQITISGASI 196

  Fly   413 MPVTKVEDVLRLIEHGSKERTSGQTSANAKSSRSHAVFQI-----ALHFPDSWGPH-------GK 465
            .|:.:..|.|:.::.|:..||:..|..|.:||||||:|.|     .|..|....|.       .|
  Fly   197 KPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDNDLETLTSK 261

  Fly   466 CSFVDLAGNERGADTQSADRQTRIEGAEINKSLLALKECIRAL---SRQSSHLPFRGSKLTQVLR 527
            ..||||||:||...||:...:.| ||..||..||||..||.||   |:::.|:|:|.||||::|:
  Fly   262 FHFVDLAGSERLKRTQATGERAR-EGISINCGLLALGNCISALGDKSKRALHVPYRDSKLTRLLQ 325

  Fly   528 DSFVGGKKNKTCMIAMISPSMSCVENTLNTLRYADRVKELIAK----EDEHLQSVEGDGEK---- 584
            ||.  |..::|.|||.:|||......|||||:||:|.:.:..|    :|:..:::.....:
  Fly   326 DSL--GGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLRREIAAL 388

  Fly   585 SPDLNEESEPEMMADEEGDEEPEDEDNQHLTISSE-------------EASSYNNMSYDMSFNHT 636
            ..:|.|..:.:::.|.||:....|..|::..:.||             ..::....:.|:..|..
  Fly   389 QLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIATLTQRNADLKTNLD 453

  Fly   637 LN--ILGPSRNVDIQEVAEQHALLVENLETYAHNFRQLKTDKEIEQYT--QNSE-----SALMKL 692
            ||  ....:.:|:|.:|..|:.|.:|.|:|......:.:...||:..|  :|::     ..:.|.
  Fly   454 LNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQMEIKATTSPRNAKPVYDSDIITKA 518

  Fly   693 LAMVNRTRDVTHN-----YNTQKLLKEENQNAYKKGELDE 727
            ...:.|.|::..:     ...|.:..||.:.|....|.:|
  Fly   519 KKDLERERELLMSRSLPGIQNQNVSSEETEVASSDSEAEE 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	131/361 (36%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	129/357 (36%)
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	131/364 (36%)
		KISc	13..370	CDD:214526	132/370 (36%)
		KASH_CCD	409..589	CDD:291334	29/150 (19%)
		RasGAP	<685..750	CDD:295371
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940