DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59D and klp-7

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001022677.1	Gene:	klp-7 / 176511	WormBaseID:	WBGene00002219	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	744	Identity:	286/744 - (38%)
Similarity:	393/744 - (52%)	Gaps:	121/744 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IGEQLLFQRSDGRVH-QVVCTAKNLERDSITGEWTEGTVVKGKEVPLSTLIGINHHIFAENQPPI 69
            :|..:..:|||||:| .|:...|:..|..:  ||.|....||||..|..|:.:|..:.|....|.
Worm    62 VGMHVEIKRSDGRIHGAVIAEVKSNGRFMV--EWYEKGETKGKESSLEELLTLNPSLQAPKPTPP 124

  Fly    70 SKPPSSLLPKPRGSSPTGGPKTHTGNPYAERMRVQDGRSKIATR-KTDPAAVGAGNHELGRAHTP 133
            .:||...|......:...|       .:|:.|.:.|..:.:... ...||...:.|.....|.|.
Worm   125 PQPPQKTLQASTAVNRQNG-------IHAQSMILDDEDTFLLDHINMIPAKGASANKRPTGAFTQ 182

  Fly   134 RVP---------------AGRPDRDASPTQGRKSQG----------------------------- 154
            .||               |..|..||:|..  ||..
Worm   183 HVPVRMAPPSEKPLPTRRAPSPKEDAAPAP--KSTRTTAAFKPDLDSTAITVPKHTARRTVVVAP 245

  Fly   155 ----------GNNSNQRFSSVVREVNRMKEQREKRRARQAEQLQEKDALRRNNPGNPNWEVSVML 209
                      .|.::||..|   .|.|:...:...|:...:.:|         |.|.|:..:.|:
Worm   246 APAPVPAPPIANMTSQRAPS---PVARVPSPKNVPRSYPQQDVQ---------PSNGNFAFAEMI 298

  Fly   210 RQYRSTLIFSPLRCLDPNGGTVQQITVCVRKRPMSRKEENSKNLDIITVPSADSLIVHELRLKVD 274
            |.||:.:.:.||...|  |....:|:|||||||:::||.....:|:||:||.|..|:|:.:.:||
Worm   299 RNYRAQIDYRPLSMFD--GVNENRISVCVRKRPLNKKELTKAEVDVITIPSRDITILHQPQTRVD 361

  Fly   275 LTKFLEHHKFRFDYTFDEECSNALVYDHTARPLIRTMFEGGNATCFAYGQTGSGKTHTMGGEFFG 339
            |||:|::.||||||:|||..:|.|||..||.||::|:|:.|.|||||||||||||||||||:|.|
Worm   362 LTKYLDNQKFRFDYSFDEYANNELVYRFTAAPLVKTVFDNGTATCFAYGQTGSGKTHTMGGDFSG 426

  Fly   340 KVQDCGTGIYAMAARDVFEEVSRPEYRQMGAKITCSFFEIYGTKVFDLLLPNKPMLRVLEDARQQ 404
            |.|:...||||:.|||||..:.:|:||:....:.|:||||||||.:| ||.:|..||||||..|:
Worm   427 KKQNASMGIYALTARDVFRMLEQPQYRRKDLSVHCAFFEIYGTKTYD-LLNDKAELRVLEDKMQK 490

  Fly   405 VVVVGLTEMPVTKVEDVLRLIEHGSKERTSGQTSANAKSSRSHAVFQIALHFPDS-WGPHGKCSF 468
            |.||||.|......:|||.||..|:..||:|.|||||.||||||:|||.|..... |   ||.|.
Worm   491 VQVVGLKEEQAHNEQDVLELINKGTLVRTAGTTSANANSSRSHAIFQIILRQGKKVW---GKFSL 552

  Fly   469 VDLAGNERGADTQSADRQTRIEGAEINKSLLALKECIRALSRQSSHLPFRGSKLTQVLRDSFVGG 533
            :||||||||.||:..||.||.|||.||.||||||||||.::|.|||:|||.||||.||||||: |
Worm   553 IDLAGNERGQDTRECDRDTRKEGANINTSLLALKECIRGMARNSSHVPFRQSKLTMVLRDSFI-G 616

  Fly   534 KKNKTCMIAMISPSMSCVENTLNTLRYADRVKELIAKEDEHLQSVEGDGEKSPDLNEE--SEPEM 596
            :|::|.||:||||.:|..::|||||||||||||:         ..:|.||.:|..:||  ..|..
Worm   617 EKSRTVMISMISPGISSSDHTLNTLRYADRVKEM---------GTDGSGEATPIRDEELFLPPSA 672

  Fly   597 -MADEEGDEEPEDEDNQHLTISSEEASSYNNMSYDMSFNHTLNILGPSRNVDIQEVAEQHALLVE 660
             .:|||.||..|.::::.:.:                 :|..|:...|     :::..:..:::.
Worm   673 DKSDEEYDEMVEKQEHRRVAV-----------------DHVRNLKDMS-----EKIIRETTIVLS 715

  Fly   661 NLETYAHNFRQLKTDKEIEQYTQNSESAL 689
            |..:.|.....|....::.|...|:..|:
Worm   716 NEPSAAQKAECLAKLDQLAQIVSNTRVAV 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	199/332 (60%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	196/327 (60%)
klp-7	NP_001022677.1	KISc_KIF2_like	320..648	CDD:276818	199/332 (60%)
klp-7	NP_001022677.1	Kinesin	326..649	CDD:278646	196/327 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156142
Domainoid	1	1.000	426	1.000	Domainoid score	I307
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I697
Isobase	1	0.950	-	0	Normalized mean entropy	S2059
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	1	1.000	-	-		otm14692
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.950