DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59D and Kif2c

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_006238694.1	Gene:	Kif2c / 171529	RGDID:	620239	Length:	722	Species:	Rattus norvegicus

Alignment Length:	743	Identity:	315/743 - (42%)
Similarity:	430/743 - (57%)	Gaps:	82/743 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RIKIGEQLLFQRSDGRVHQVVCTAKNLERDSITGEWTEGTVVKGKEVPLSTLIGINHHIFAENQP 67
            |:..|..:..|||:|.:|....:..|||:..::.|||||...||||:.:..:..||..:.  ...
  Rat     7 RLFPGLSINIQRSNGLIHSANISTVNLEKSCVSVEWTEGGTTKGKEIDIDDVAAINPELV--QLL 69

  Fly    68 PISKPPSSL-------LPKPRGSSPTG---GPK-------THTGNPYAERMRVQDGRSK----IA 111
            |: :|..||       :||.:..|...   |||       |........|:..|:...:    ::
  Rat    70 PL-RPKDSLPLQENVTIPKQKRKSVNSKIPGPKEGLRSRSTRISTVSEVRIPAQENEMEVELPVS 133

  Fly   112 TRKTDPAAVGAGNHELGRAHTPRVP----AGRPDRDASPTQGRKSQGGNNSNQRFSSVVREVNRM 172
            |....|..:..|:.....:....:|    :...:..|..|:...|....||.:|.|.:|:|:.:|
  Rat   134 TNSRKPFPIHTGHPRPSCSTVTELPLLMISEEAEEQAHSTRSTSSANPGNSVRRKSCIVKEMEKM 198

  Fly   173 KEQREKRRARQAEQLQEKDALRRNNPGNPNWEVSVMLRQYRSTLIFSPLRCLDPNGGTVQQ--IT 235
            |.:||::||:.:| ::.|.|...:| ..||||.:.|::::|.|:..:||...||    :::  |.
  Rat   199 KNKREEKRAQNSE-IRIKRAQEYDN-SFPNWEFARMIKEFRVTMDCNPLTVTDP----IEEHRIC 257

  Fly   236 VCVRKRPMSRKEENSKNLDIITVPSADSLIVHELRLKVDLTKFLEHHKFRFDYTFDEECSNALVY 300
            |||||||::::|...|.:|:|:|||...|:|||.:|||||||:||:..|.||:.|||..||.:||
  Rat   258 VCVRKRPLNKQELAKKEIDVISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVY 322

  Fly   301 DHTARPLIRTMFEGGNATCFAYGQTGSGKTHTMGGEFFGKVQDCGTGIYAMAARDVFEEVSRPEY 365
            ..|||||::|:||||.|||||||||||||||||||:..||.|:...||||||:||||...::|.|
  Rat   323 RFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKSQNASKGIYAMASRDVFLLKNQPRY 387

  Fly   366 RQMGAKITCSFFEIYGTKVFDLLLPNKPMLRVLEDARQQVVVVGLTEMPVTKVEDVLRLIEHGSK 430
            |.:..::..:|||||..|||| ||..|..||||||::|||.||||.|..||..:||:::|..||.
  Rat   388 RSLNLEVYVTFFEIYNGKVFD-LLNKKAKLRVLEDSKQQVQVVGLQEYLVTCADDVIKMINMGSA 451

  Fly   431 ERTSGQTSANAKSSRSHAVFQIALHFPDSWGPHGKCSFVDLAGNERGADTQSADRQTRIEGAEIN 495
            .||||||.||:.||||||.|||.|......  |||.|.||||||||||||.|||||||:||||||
  Rat   452 CRTSGQTFANSNSSRSHACFQILLRAKGRL--HGKFSLVDLAGNERGADTSSADRQTRMEGAEIN 514

  Fly   496 KSLLALKECIRALSRQSSHLPFRGSKLTQVLRDSFVGGKKNKTCMIAMISPSMSCVENTLNTLRY 560
            |||||||||||||.:..:|.|||.|||||||||||: |:.::|||||||||.:|..|.|||||||
  Rat   515 KSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFI-GENSRTCMIAMISPGISSCEYTLNTLRY 578

  Fly   561 ADRVKELIAKEDEHLQSVEGDGEKSPDLNEESEPEMMADEEGDEEPEDEDNQHLTISSEEASSYN 625
            |||||||......       .||::..:..|   ||.|...|.....:|:        ||.||
  Rat   579 ADRVKELSPHSGP-------SGEQAVQMETE---EMDASSHGASLTGNEE--------EELSS-- 623

  Fly   626 NMSYDMSFNHTLNILGPSRNVDIQEVAEQHALLVENLETYAHNFRQL-----KTDKEIEQYTQNS 685
            .||   |||..:        ..|:|:.|:....:..:.....::.:|     :.|.::|.:...:
  Rat   624 QMS---SFNEAM--------TQIRELEERAMEELREIIQQGPSWLELSEMTDQPDYDLETFVNKA 677

  Fly   686 ESALMKLLAMVNRTRDVTHNYNTQKLLK 713
            ||||      ..:.:...|....|:::|
  Rat   678 ESAL------TQQAKQAKHFSALQEVIK 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	213/333 (64%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	210/326 (64%)
Kif2c	XP_006238694.1	KISc_KIF2_like	255..583	CDD:276818	213/331 (64%)
Kif2c	XP_006238694.1	Kinesin	261..584	CDD:278646	210/326 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334491
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0246
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.810