DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp59D and KIF2C

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_006836.2	Gene:	KIF2C / 11004	HGNCID:	6393	Length:	725	Species:	Homo sapiens

Alignment Length:	765	Identity:	318/765 - (41%)
Similarity:	428/765 - (55%)	Gaps:	97/765 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RIKIGEQLLFQRSDGRVHQVVCTAKNLERDSITGEWTEGTVVKGKEVPLSTLIGINHHIF----- 62
            |:..|..:..|||:|.:|.......|||:..::.||.||...||||:....:..||..:.
Human    10 RLFPGLAIKIQRSNGLIHSANVRTVNLEKSCVSVEWAEGGATKGKEIDFDDVAAINPELLQLLPL 74

  Fly    63 --AENQP-----PISKPP----SSLLPKPRGSSPTGGPKTHTGN---------------PYAERM 101
              .:|.|     .|.|..    :|.:|.|:.|..:...:..|.:               |.|...
Human    75 HPKDNLPLQENVTIQKQKRRSVNSKIPAPKESLRSRSTRMSTVSELRITAQENDMEVELPAAANS 139

  Fly   102 RVQDGRSKIATRKTDPAAVGAGNHELGRAHTP-RVPAGRPDRDASPTQGRKSQGGNNSNQRFSSV 165
            |.|.......||.:.||.          |..| |:.:...:......:|..|....||.:|.|.:
Human   140 RKQFSVPPAPTRPSCPAV----------AEIPLRMVSEEMEEQVHSIRGSSSANPVNSVRRKSCL 194

  Fly   166 VREVNRMKEQREKRRARQAE----QLQEKDALRRNNPGNPNWEVSVMLRQYRSTLIFSPLRCLDP 226
            |:||.:||.:||:::|:.:|    :.||.|:      ..||||.:.|::::|:||...||...||
Human   195 VKEVEKMKNKREEKKAQNSEMRMKRAQEYDS------SFPNWEFARMIKEFRATLECHPLTMTDP 253

  Fly   227 NGGTVQQ--ITVCVRKRPMSRKEENSKNLDIITVPSADSLIVHELRLKVDLTKFLEHHKFRFDYT 289
                :::  |.|||||||::::|...|.:|:|::||...|:|||.:|||||||:||:..|.||:.
Human   254 ----IEEHRICVCVRKRPLNKQELAKKEIDVISIPSKCLLLVHEPKLKVDLTKYLENQAFCFDFA 314

  Fly   290 FDEECSNALVYDHTARPLIRTMFEGGNATCFAYGQTGSGKTHTMGGEFFGKVQDCGTGIYAMAAR 354
            |||..||.:||..|||||::|:||||.|||||||||||||||||||:..||.|:...||||||:|
Human   315 FDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKAQNASKGIYAMASR 379

  Fly   355 DVFEEVSRPEYRQMGAKITCSFFEIYGTKVFDLLLPNKPMLRVLEDARQQVVVVGLTEMPVTKVE 419
            |||...::|.||::|.::..:|||||..|:|| ||..|..||||||.:|||.||||.|..|...:
Human   380 DVFLLKNQPCYRKLGLEVYVTFFEIYNGKLFD-LLNKKAKLRVLEDGKQQVQVVGLQEHLVNSAD 443

  Fly   420 DVLRLIEHGSKERTSGQTSANAKSSRSHAVFQIALHFPDSWGPHGKCSFVDLAGNERGADTQSAD 484
            ||:::|:.||..||||||.||:.||||||.|||.|......  |||.|.||||||||||||.|||
Human   444 DVIKMIDMGSACRTSGQTFANSNSSRSHACFQIILRAKGRM--HGKFSLVDLAGNERGADTSSAD 506

  Fly   485 RQTRIEGAEINKSLLALKECIRALSRQSSHLPFRGSKLTQVLRDSFVGGKKNKTCMIAMISPSMS 549
            ||||:|||||||||||||||||||.:..:|.|||.|||||||||||: |:.::|||||.|||.:|
Human   507 RQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFI-GENSRTCMIATISPGIS 570

  Fly   550 CVENTLNTLRYADRVKELIAKEDEHLQSVEGDGEKSPDLNEESEPEMMADEEGDEEPEDEDNQHL 614
            ..|.||||||||||||||    ..|      .|.....|.:....||.|...|...|.:
Human   571 SCEYTLNTLRYADRVKEL----SPH------SGPSGEQLIQMETEEMEACSNGALIPGN------ 619

  Fly   615 TISSEEASSYNNMSYDMSFNHTLNILGPSRNVDIQEVAEQHALLVENLETYAHNFRQL-----KT 674
             :|.||....:.||   |||..:        ..|:|:.|:....::.:.....::.:|     :.
Human   620 -LSKEEEELSSQMS---SFNEAM--------TQIRELEEKAMEELKEIIQQGPDWLELSEMTEQP 672

  Fly   675 DKEIEQYTQNSESALMKLLAMVNRTRDVTHNYNTQKLLKEE--NQNAYKK 722
            |.::|.:...:||||.:.....:..|||.........|:|:  .|.:.||
Human   673 DYDLETFVNKAESALAQQAKHFSALRDVIKALRLAMQLEEQASRQISSKK 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	210/333 (63%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	207/326 (63%)
KIF2C	NP_006836.2	Globular. /evidence=ECO:0000255	2..254		70/263 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..116		5/26 (19%)
		Microtubule tip localization signal	98..101		1/2 (50%)
		Negative regulator of microtubule-binding. /evidence=ECO:0000250	207..238		10/36 (28%)
		KISc_KIF2_like	258..586	CDD:276818	210/331 (63%)
		Nuclear localization signal. /evidence=ECO:0000255	415..418		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140813
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0246
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.810