DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp59D and kif2a

DIOPT Version :9

Sequence 1:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_002934245.2	Gene:	kif2a / 100379688	XenbaseID:	XB-GENE-951755	Length:	745	Species:	Xenopus tropicalis

Alignment Length:	763	Identity:	332/763 - (43%)
Similarity:	444/763 - (58%)	Gaps:	85/763 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RIKIGEQLLFQRSDGRVHQVVCTAKNLERDSITGEWTEGTVVKGKEVPLSTLIGINHHIFAENQP 67
            :|.||..:..:|||||:||.:.|:.|.:.:|||.||.|....||||:.|.::..:|..:    .|
Frog     7 KIHIGIYVEIKRSDGRIHQAMVTSLNEDSESITVEWIENGDTKGKEIDLESIFSLNPDL----AP 67

  Fly    68 PISKPPSSLLPKPRGSSPTGGPKTHTGNPYAERMRVQDGRSKIATRKTDPAAVGAGNHELGRAHT 132
            .....|...:|.|    ||  |.|........|..|...:::...|....|||.:..   .|...
Frog    68 DEEIDPGPEMPPP----PT--PTTKVNKIVKNRRTVAPVKNETPARDNRVAAVSSAR---ARPSQ 123

  Fly   133 PRVPAGRPDR-----DASPTQGRKSQGGNNSNQRFSSVVREVNRMKEQREKRRARQAEQLQEKDA 192
            |...:....:     |.||.|..|...|..| :|.|:.|:||.:::|:|||||.:| ::|:||.|
Frog   124 PIEQSASAQQNGSVSDISPDQPGKKDFGPPS-RRKSNCVKEVEKLQEKREKRRLQQ-QELREKKA 186

  Fly   193 LRRNNPGNPNWEVSVMLRQYRSTLIFSPLRCLDPNGGTVQQ--ITVCVRKRPMSRKEENSKNLDI 255
             :..:..|||:|:..|::.:|.:|.:.||...|    |:.:  |.|||||||:::||...|:||:
Frog   187 -QDVDATNPNYEIMCMIKDFRGSLDYRPLTTAD----TIDEHRICVCVRKRPLNKKENTVKDLDV 246

  Fly   256 ITVPSADSLIVHELRLKVDLTKFLEHHKFRFDYTFDEECSNALVYDHTARPLIRTMFEGGNATCF 320
            ||:||.|.::|||.:.|||||:|||:..|||||.|||...|.:||..|||||:.|:||.|.||||
Frog   247 ITIPSKDVVMVHEPKQKVDLTRFLENQTFRFDYAFDETAPNEMVYRFTARPLVETIFERGMATCF 311

  Fly   321 AYGQTGSGKTHTMGGEFFGKVQDCGTGIYAMAARDVFEEVSRPEYRQMGAKITCSFFEIYGTKVF 385
            |||||||||||||||:|.||.|||..||||:||||||:.:.:|.|:::..::..:|||||..|||
Frog   312 AYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFQMLKKPNYKKLELQVYATFFEIYSGKVF 376

  Fly   386 DLLLPNKPMLRVLEDARQQVVVVGLTEMPVTKVEDVLRLIEHGSKERTSGQTSANAKSSRSHAVF 450
            | ||..|..||||||.:|||.||||.|..|..|||||:|||.|:..||||||||||.||||||||
Frog   377 D-LLNRKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIEIGNSCRTSGQTSANAHSSRSHAVF 440

  Fly   451 QIALHFPDSWGPHGKCSFVDLAGNERGADTQSADRQTRIEGAEINKSLLALKECIRALSRQSSHL 515
            ||.|......  |||.|.:|||||||||||.|||||||:|||||||||||||||||||.|...|.
Frog   441 QIILRRKGKL--HGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHT 503

  Fly   516 PFRGSKLTQVLRDSFVGGKKNKTCMIAMISPSMSCVENTLNTLRYADRVKEL-IAKEDEHLQSVE 579
            |||.|||||||||||: |:.::|||||.|||.|:..||||||||||:||||. |:..|  :...:
Frog   504 PFRASKLTQVLRDSFI-GENSRTCMIATISPGMASCENTLNTLRYANRVKEFGISPSD--IPFSQ 565

  Fly   580 GDGEK------------SPDLNEESE------------------PEMMADEEG----DEEPEDED 610
            |.|.:            ||.|....|                  |..:.|.|.    ...|:.:|
Frog   566 GSGSRSDLSPSYEYDDFSPTLTRVKELTVDPSAAGDLRPMIHHAPNQLDDVEALWGVGSSPQRDD 630

  Fly   611 NQHLTISSEEASSYNNMSYDMSFNHTLNILGPSRNVDIQE-VAEQHALLVENLETYAHNFRQL-- 672
            .:.|...:||..|....::..:.         |:.|:::| |.|.|..:.:....:..:.:.|
Frog   631 LKLLCEQNEEEVSPQLFTFHEAV---------SQMVEMEEQVVEDHRAVFQESIRWLEDEKVLLE 686

  Fly   673 ---KTDKEIEQYTQNSESALMKLLAMVNRTRDVTHNYNTQKLLKEENQ 717
               :.|.:::.|....|:.|.:.:.::...||...::  :..|:||.|
Frog   687 MTEEVDYDVDSYATQLEAILEQKIDILTELRDKVKSF--RAALQEEEQ 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	221/333 (66%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	218/326 (67%)
kif2a	XP_002934245.2	KISc_KIF2_like	224..552	CDD:276818	221/331 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202066at33208
OrthoFinder	1	1.000	-	-		FOG0001531
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010